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B1WUD4 (AROB_CYAA5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:cce_4440
OrganismCyanothece sp. (strain ATCC 51142) [Complete proteome] [HAMAP]
Taxonomic identifier43989 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3653653-dehydroquinate synthase HAMAP MF_00110
PRO_1000094501

Sequences

Sequence LengthMass (Da)Tools
B1WUD4 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 24C11758B14D45A4

FASTA36540,067
        10         20         30         40         50         60 
MSSVIQVNLP QTSYNIIISP NSLGSVGRHL TSLNLEQKIL VISNPEIFDY YGEIVINSLK 

        70         80         90        100        110        120 
QAGFKVFSHV IPAGETYKTL DSISKIYDTA LKHRLERAST LLALGGGVIG DMTGFAAATW 

       130        140        150        160        170        180 
LRGINFIQVP TSLLAMVDAS IGGKTGVNHP QGKNLIGAFY QPRLVLIDPI VLKTLPVREF 

       190        200        210        220        230        240 
RAGMAEVIKY GVIWNQGLFN QLERQKKLDS LDSINLETIQ TIITQSCQAK VDVVSQDEKE 

       250        260        270        280        290        300 
AGLRAILNYG HTIGHALESL TGYREINHGE AVALGMVAAG KIAVKLGMWK EEMSQRQKNI 

       310        320        330        340        350        360 
IQKAALPVIV DYPLKSQAIL ESLQLDKKVK AGKVRFILPT DIGQVEIREG VPSEVITRVL 


EEIKM

« Hide

References

[1]"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle."
Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C., Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K., Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B.
Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008) [PubMed: 18812508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51142.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000806 Genomic DNA. Translation: ACB53788.1.
RefSeqYP_001805854.1. NC_010546.1.

3D structure databases

ProteinModelPortalB1WUD4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1WUD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6171518.
GenomeReviewsGene locus cce_4440 in contig CP000806_GR.
KEGGcyt:cce_4440.
PATRIC21547216. VBICyaSp130209_4412.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBB1WUD4.
ProtClustDBCLSK2332666.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CYAA5
AccessionPrimary (citable) accession number: B1WUD4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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