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B1WTK3

- ASSY_CYAA5

UniProt

B1WTK3 - ASSY_CYAA5

Protein

Argininosuccinate synthase

Gene

argG

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei89 – 891CitrullineUniRule annotation
    Binding sitei119 – 1191ATP; via amide nitrogenUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei129 – 1291CitrullineUniRule annotation
    Binding sitei177 – 1771CitrullineUniRule annotation
    Binding sitei186 – 1861CitrullineUniRule annotation
    Binding sitei262 – 2621CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP43989:GKC8-4425-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:cce_4370
    OrganismiCyanothece sp. (strain ATCC 51142)
    Taxonomic identifieri43989 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000001203: Chromosome circular

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Argininosuccinate synthasePRO_1000089034Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi43989.cce_4370.

    Structurei

    3D structure databases

    ProteinModelPortaliB1WTK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1WTK3-1 [UniParc]FASTAAdd to Basket

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    MGRAKKVVLA YSGGVDTSVC IPYLKHEWGV DEVITLAADL GQGDELGPIQ    50
    AKALKSGAVE SLVEDATAEF VTDYAFKAIK ANALYESRYP LSTALARPLI 100
    AKLLVEAAEK YGADAVAHGC TAKGNDQVRF DLGILALNPT LKVLAPAREW 150
    KMSREQTIAY GEKFGLDFPV KKSSPFSIDR NLLGRSIEAG PLEDPMTEPP 200
    EEIYLMTKAI ADTPDTPEYV EIGFEKGLPV SLNGQTLDPV TLISQLNDVV 250
    GKHGVGRIDM IENRVVGIKS REIYEAPALL VLIDAHRDLE SLTLTSDVTH 300
    YKKGVEETYS HLIYRGLWYS PLKESLDAFI DHTQERVNGT VRIKLFKGNA 350
    NIVGRQSDYS IYSPNLATYG EDDHFDHKAA EGFIYIWGLP TRVWAEKTKG 400
    Length:400
    Mass (Da):44,046
    Last modified:May 20, 2008 - v1
    Checksum:iF3F08AA22D355679
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000806 Genomic DNA. Translation: ACB53718.1.
    RefSeqiYP_001805784.1. NC_010546.1.

    Genome annotation databases

    EnsemblBacteriaiACB53718; ACB53718; cce_4370.
    GeneIDi6171448.
    KEGGicyt:cce_4370.
    PATRICi21547078. VBICyaSp130209_4343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000806 Genomic DNA. Translation: ACB53718.1 .
    RefSeqi YP_001805784.1. NC_010546.1.

    3D structure databases

    ProteinModelPortali B1WTK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 43989.cce_4370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB53718 ; ACB53718 ; cce_4370 .
    GeneIDi 6171448.
    KEGGi cyt:cce_4370.
    PATRICi 21547078. VBICyaSp130209_4343.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci CSP43989:GKC8-4425-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51142.

    Entry informationi

    Entry nameiASSY_CYAA5
    AccessioniPrimary (citable) accession number: B1WTK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3