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B1WSK6

- SYL_CYAA5

UniProt

B1WSK6 - SYL_CYAA5

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Protein

Leucine--tRNA ligase

Gene
leuS, cce_4237
Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei618 – 6181ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP43989:GKC8-4291-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:cce_4237
OrganismiCyanothece sp. (strain ATCC 51142)
Taxonomic identifieri43989 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000001203: Chromosome circular

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853Leucine--tRNA ligaseUniRule annotationPRO_1000091311Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi43989.cce_4237.

Structurei

3D structure databases

ProteinModelPortaliB1WSK6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi615 – 6195"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WSK6-1 [UniParc]FASTAAdd to Basket

« Hide

MESQYNAAEI EQKWQQDWVN QGLDKTPENS DKPKFYALSM FPYPSGNLHM    50
GHVRNYVITD VIARLKRLQG YRVLHPMGWD AFGLPAENAA IDRNIPPADW 100
TYKNIAQMKQ QLQTLGLSID WDREVATCSP DYYKWTQWLF LQFYQAGLAY 150
QKEAAVNWDP IDQTVLANEQ VDSEGYSWRS GAKVERKLLR QWFFKITDYA 200
EQLLTDLDKL TGWPDRVKLM QENWIGKSVG AYLEFPVKGS EEKIAVFTTR 250
PDTVYGVTYV VLAPEHPLTP KVTTEGQKEA VEAFIEEVSN ESEIERTAED 300
KPKRGILTGG TAVNPFNGEE IPILIADYVL YEYGTGAVMG VPAHDTRDFK 350
FATEKELPIK VVIVPENSED NNPTLTEAYT EPGIMVNSGE FNGMQSTEGK 400
TAIINYAEKQ GYGKARIQYR LRDWLISRQR YWGCPIPVVH CPSCGTVAVP 450
DADLPVKLPE NVEFTGRGAS PLAKMEDWIN VPCPSCGEPA KRETDTMDTF 500
IDSSWYYLRY TDAMNDQEAF KLEKANDWMN VDQYVGGIEH AILHLLYSRF 550
FTKVLRDRGL VNVDEPFKRL LTQGMVQAMA YKNPKTGKYI PVDKVNPESP 600
KDPDTGDDLE VFYEKMSKSK YNGVDPQKVL GKYGADTARM FILFKAPPEK 650
DLEWDDADVE GQFRFLNRVW RLVNGYEKKQ GEVISNKELS KEEKDLRRAI 700
HTAIKEISED LEGDYQFNTA VSELMKLSNA LNDAKCINSE VYQEGIETLL 750
ILLAPFAPHI AEELWHNLGH ETSIHLETWP QVDPDALVVD EITLVIQIMG 800
KTRGTIQVPA NSSKEELEKL ARESDIGQRN LDGKEVKKVI VVPGKLVNFV 850
VPK 853
Length:853
Mass (Da):97,000
Last modified:May 20, 2008 - v1
Checksum:i0D93907DD31424C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000806 Genomic DNA. Translation: ACB53585.1.
RefSeqiYP_001805651.1. NC_010546.1.

Genome annotation databases

EnsemblBacteriaiACB53585; ACB53585; cce_4237.
GeneIDi6171313.
KEGGicyt:cce_4237.
PATRICi21546814. VBICyaSp130209_4212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000806 Genomic DNA. Translation: ACB53585.1 .
RefSeqi YP_001805651.1. NC_010546.1.

3D structure databases

ProteinModelPortali B1WSK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 43989.cce_4237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB53585 ; ACB53585 ; cce_4237 .
GeneIDi 6171313.
KEGGi cyt:cce_4237.
PATRICi 21546814. VBICyaSp130209_4212.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSP43989:GKC8-4291-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51142.

Entry informationi

Entry nameiSYL_CYAA5
AccessioniPrimary (citable) accession number: B1WSK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi