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B1WSK6

- SYL_CYAA5

UniProt

B1WSK6 - SYL_CYAA5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei618 – 6181ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP43989:GKC8-4291-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:cce_4237
OrganismiCyanothece sp. (strain ATCC 51142)
Taxonomic identifieri43989 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000001203: Chromosome circular

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853Leucine--tRNA ligasePRO_1000091311Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi43989.cce_4237.

Structurei

3D structure databases

ProteinModelPortaliB1WSK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi615 – 6195"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WSK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESQYNAAEI EQKWQQDWVN QGLDKTPENS DKPKFYALSM FPYPSGNLHM
60 70 80 90 100
GHVRNYVITD VIARLKRLQG YRVLHPMGWD AFGLPAENAA IDRNIPPADW
110 120 130 140 150
TYKNIAQMKQ QLQTLGLSID WDREVATCSP DYYKWTQWLF LQFYQAGLAY
160 170 180 190 200
QKEAAVNWDP IDQTVLANEQ VDSEGYSWRS GAKVERKLLR QWFFKITDYA
210 220 230 240 250
EQLLTDLDKL TGWPDRVKLM QENWIGKSVG AYLEFPVKGS EEKIAVFTTR
260 270 280 290 300
PDTVYGVTYV VLAPEHPLTP KVTTEGQKEA VEAFIEEVSN ESEIERTAED
310 320 330 340 350
KPKRGILTGG TAVNPFNGEE IPILIADYVL YEYGTGAVMG VPAHDTRDFK
360 370 380 390 400
FATEKELPIK VVIVPENSED NNPTLTEAYT EPGIMVNSGE FNGMQSTEGK
410 420 430 440 450
TAIINYAEKQ GYGKARIQYR LRDWLISRQR YWGCPIPVVH CPSCGTVAVP
460 470 480 490 500
DADLPVKLPE NVEFTGRGAS PLAKMEDWIN VPCPSCGEPA KRETDTMDTF
510 520 530 540 550
IDSSWYYLRY TDAMNDQEAF KLEKANDWMN VDQYVGGIEH AILHLLYSRF
560 570 580 590 600
FTKVLRDRGL VNVDEPFKRL LTQGMVQAMA YKNPKTGKYI PVDKVNPESP
610 620 630 640 650
KDPDTGDDLE VFYEKMSKSK YNGVDPQKVL GKYGADTARM FILFKAPPEK
660 670 680 690 700
DLEWDDADVE GQFRFLNRVW RLVNGYEKKQ GEVISNKELS KEEKDLRRAI
710 720 730 740 750
HTAIKEISED LEGDYQFNTA VSELMKLSNA LNDAKCINSE VYQEGIETLL
760 770 780 790 800
ILLAPFAPHI AEELWHNLGH ETSIHLETWP QVDPDALVVD EITLVIQIMG
810 820 830 840 850
KTRGTIQVPA NSSKEELEKL ARESDIGQRN LDGKEVKKVI VVPGKLVNFV

VPK
Length:853
Mass (Da):97,000
Last modified:May 20, 2008 - v1
Checksum:i0D93907DD31424C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB53585.1.
RefSeqiYP_001805651.1. NC_010546.1.

Genome annotation databases

EnsemblBacteriaiACB53585; ACB53585; cce_4237.
GeneIDi6171313.
KEGGicyt:cce_4237.
PATRICi21546814. VBICyaSp130209_4212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB53585.1 .
RefSeqi YP_001805651.1. NC_010546.1.

3D structure databases

ProteinModelPortali B1WSK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 43989.cce_4237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB53585 ; ACB53585 ; cce_4237 .
GeneIDi 6171313.
KEGGi cyt:cce_4237.
PATRICi 21546814. VBICyaSp130209_4212.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSP43989:GKC8-4291-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51142.

Entry informationi

Entry nameiSYL_CYAA5
AccessioniPrimary (citable) accession number: B1WSK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3