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B1WSK6

- SYL_CYAA5

UniProt

B1WSK6 - SYL_CYAA5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei618 – 6181ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP43989:GKC8-4291-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:cce_4237
    OrganismiCyanothece sp. (strain ATCC 51142)
    Taxonomic identifieri43989 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000001203: Chromosome circular

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 853853Leucine--tRNA ligasePRO_1000091311Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi43989.cce_4237.

    Structurei

    3D structure databases

    ProteinModelPortaliB1WSK6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi615 – 6195"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1WSK6-1 [UniParc]FASTAAdd to Basket

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    MESQYNAAEI EQKWQQDWVN QGLDKTPENS DKPKFYALSM FPYPSGNLHM    50
    GHVRNYVITD VIARLKRLQG YRVLHPMGWD AFGLPAENAA IDRNIPPADW 100
    TYKNIAQMKQ QLQTLGLSID WDREVATCSP DYYKWTQWLF LQFYQAGLAY 150
    QKEAAVNWDP IDQTVLANEQ VDSEGYSWRS GAKVERKLLR QWFFKITDYA 200
    EQLLTDLDKL TGWPDRVKLM QENWIGKSVG AYLEFPVKGS EEKIAVFTTR 250
    PDTVYGVTYV VLAPEHPLTP KVTTEGQKEA VEAFIEEVSN ESEIERTAED 300
    KPKRGILTGG TAVNPFNGEE IPILIADYVL YEYGTGAVMG VPAHDTRDFK 350
    FATEKELPIK VVIVPENSED NNPTLTEAYT EPGIMVNSGE FNGMQSTEGK 400
    TAIINYAEKQ GYGKARIQYR LRDWLISRQR YWGCPIPVVH CPSCGTVAVP 450
    DADLPVKLPE NVEFTGRGAS PLAKMEDWIN VPCPSCGEPA KRETDTMDTF 500
    IDSSWYYLRY TDAMNDQEAF KLEKANDWMN VDQYVGGIEH AILHLLYSRF 550
    FTKVLRDRGL VNVDEPFKRL LTQGMVQAMA YKNPKTGKYI PVDKVNPESP 600
    KDPDTGDDLE VFYEKMSKSK YNGVDPQKVL GKYGADTARM FILFKAPPEK 650
    DLEWDDADVE GQFRFLNRVW RLVNGYEKKQ GEVISNKELS KEEKDLRRAI 700
    HTAIKEISED LEGDYQFNTA VSELMKLSNA LNDAKCINSE VYQEGIETLL 750
    ILLAPFAPHI AEELWHNLGH ETSIHLETWP QVDPDALVVD EITLVIQIMG 800
    KTRGTIQVPA NSSKEELEKL ARESDIGQRN LDGKEVKKVI VVPGKLVNFV 850
    VPK 853
    Length:853
    Mass (Da):97,000
    Last modified:May 20, 2008 - v1
    Checksum:i0D93907DD31424C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000806 Genomic DNA. Translation: ACB53585.1.
    RefSeqiYP_001805651.1. NC_010546.1.

    Genome annotation databases

    EnsemblBacteriaiACB53585; ACB53585; cce_4237.
    GeneIDi6171313.
    KEGGicyt:cce_4237.
    PATRICi21546814. VBICyaSp130209_4212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000806 Genomic DNA. Translation: ACB53585.1 .
    RefSeqi YP_001805651.1. NC_010546.1.

    3D structure databases

    ProteinModelPortali B1WSK6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 43989.cce_4237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB53585 ; ACB53585 ; cce_4237 .
    GeneIDi 6171313.
    KEGGi cyt:cce_4237.
    PATRICi 21546814. VBICyaSp130209_4212.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CSP43989:GKC8-4291-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51142.

    Entry informationi

    Entry nameiSYL_CYAA5
    AccessioniPrimary (citable) accession number: B1WSK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3