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B1WSG7

- DAPAT_CYAA5

UniProt

B1WSG7 - DAPAT_CYAA5

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Protein

LL-diaminopimelate aminotransferase

Gene
dapL, cce_2605
Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogen By similarity
Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partner By similarity
Binding sitei75 – 751Substrate; shared with dimeric partner By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei187 – 1871Pyridoxal phosphate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei215 – 2151Pyridoxal phosphate By similarity
Binding sitei218 – 2181Pyridoxal phosphate By similarity
Binding sitei246 – 2461Pyridoxal phosphate By similarity
Binding sitei248 – 2481Pyridoxal phosphate By similarity
Binding sitei257 – 2571Pyridoxal phosphate By similarity
Binding sitei292 – 2921Substrate; shared with dimeric partner By similarity
Binding sitei388 – 3881Substrate By similarity

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCSP43989:GKC8-2641-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase (EC:2.6.1.83)
Short name:
DAP-AT
Short name:
DAP-aminotransferase
Short name:
LL-DAP-aminotransferase
Gene namesi
Name:dapL
Ordered Locus Names:cce_2605
OrganismiCyanothece sp. (strain ATCC 51142)
Taxonomic identifieri43989 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000001203: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411LL-diaminopimelate aminotransferaseUniRule annotationPRO_1000186860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi43989.cce_2605.

Structurei

3D structure databases

ProteinModelPortaliB1WSG7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OMAiHAPYVWL.
OrthoDBiEOG6XWV2X.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WSG7-1 [UniParc]FASTAAdd to Basket

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MATINDNYLK LKAGYLFPEI ARRVNTFIEA NPEAKIIKLG IGDVTEPLPE    50
ACRTAMIKAV EDMGDRSSFK GYGPEQGYGW LREKIAAQDF QARGCDIDAS 100
EIFVSDGAKC DTGNILDIFG KNNKIAVTDP VYPVYVDTNV MAGHTGETNE 150
KGEYEGLVYL PISADNHFVA DIPSEKVDLI YLCFPNNPTG ATATKEYLKA 200
WVDYATANDS IIFFDAAYEA FITDESLPHS IYEIEGAKDC AIEFRSFSKN 250
AGFTGTRCAF TVVPKQLTAK ASDGSQVELW KLWNRRQSTK FNGVSYIVQR 300
GAEAVYSEAG KAQIKGLVSF YLENAKIICE QLKSAGFEVY GGVNAPYIWL 350
KTPHNLSSWD FFDKLLQTTH VVGTPGSGFG AAGEGYFRIS AFNSRENVEE 400
AMKRITQAFK V 411
Length:411
Mass (Da):45,374
Last modified:May 20, 2008 - v1
Checksum:i97CAC8BC8F6A582C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000806 Genomic DNA. Translation: ACB51953.1.
RefSeqiYP_001804019.1. NC_010546.1.

Genome annotation databases

EnsemblBacteriaiACB51953; ACB51953; cce_2605.
GeneIDi6169662.
KEGGicyt:cce_2605.
PATRICi21543636. VBICyaSp130209_2639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000806 Genomic DNA. Translation: ACB51953.1 .
RefSeqi YP_001804019.1. NC_010546.1.

3D structure databases

ProteinModelPortali B1WSG7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 43989.cce_2605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB51953 ; ACB51953 ; cce_2605 .
GeneIDi 6169662.
KEGGi cyt:cce_2605.
PATRICi 21543636. VBICyaSp130209_2639.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223061.
KOi K10206.
OMAi HAPYVWL.
OrthoDBi EOG6XWV2X.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci CSP43989:GKC8-2641-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51142.

Entry informationi

Entry nameiDAPAT_CYAA5
AccessioniPrimary (citable) accession number: B1WSG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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