B1WR40 (ADE_CYAA5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

cce_0747

Organism

Cyanothece sp. (strain ATCC 51142) [Complete proteome] [HAMAP]

Taxonomic identifier

43989 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Adenine deaminase HAMAP MF_01962		PRO_1000146569
Sites
	Active site	197	1	Proton donor By similarity
	Metal binding	14	1	Zinc; catalytic By similarity
	Metal binding	16	1	Zinc; catalytic By similarity
	Metal binding	194	1	Zinc; catalytic By similarity
	Metal binding	275	1	Zinc; catalytic By similarity
	Binding site	276	1	Substrate By similarity
	Site	218	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1WR40 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: A148935ECFD3A81F	FASTA	326	37,116
	10 20 30 40 50 60 MKTLIEQLPK AELHIHIEGS LEPELMFKLA QRNHQRLSFS SVEEAKQAYQ FNDLQSFLNI 70 80 90 100 110 120 YYQGANVLYG EEDFYDLTWN YLEKAKKQNI CHTEIFFDPQ THTNRGVPFA AIITGITEAL 130 140 150 160 170 180 KAGKDQLGIS SYLILCFLRD LTVESAFETL EQAIKYGEKI KAIGLDSAEK NNPPSKFKEV 190 200 210 220 230 240 FDKARAEGFL TVAHAGEEGS SDYIWQAINL LKVSRIDHGI RCIDDPKLVE YLAEKQIPLT 250 260 270 280 290 300 VCPLSNVKLK VFNCLEDHNL KILLDQGLCV TINSDDPAYF GGYLNENFLA ISQALRLTEI 310 320 DLQKMINNSF RASFLNTSEK EQLYIQ

References

[1]

"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C., Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K., Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B. Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008) [PubMed: 18812508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51142.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000806 Genomic DNA. Translation: ACB50098.1.
RefSeq	YP_001802164.1. NC_010546.1.
3D structure databases
ProteinModelPortal	B1WR40.
ModBase	Search...
Protein-protein interaction databases
STRING	B1WR40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6167781.
GenomeReviews	Gene locus cce_0747 in contig CP000806_GR.
KEGG	cyt:cce_0747.
PATRIC	21539956. VBICyaSp130209_0821.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	FGGYVDD.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_CYAA5

Accession

Primary (citable) accession number: B1WR40

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program