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Protein

Ribonuclease Z

Gene

rnz

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Zinc 1; catalyticUniRule annotation
Metal bindingi64 – 641Zinc 1; catalyticUniRule annotation
Active sitei66 – 661Proton acceptorUniRule annotation
Metal bindingi66 – 661Zinc 2; catalyticUniRule annotation
Metal bindingi67 – 671Zinc 2; catalyticUniRule annotation
Metal bindingi139 – 1391Zinc 1; catalyticUniRule annotation
Metal bindingi210 – 2101Zinc 1; catalyticUniRule annotation
Metal bindingi210 – 2101Zinc 2; catalyticUniRule annotation
Metal bindingi268 – 2681Zinc 2; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCSP43989:GKC8-4120-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:cce_4065
OrganismiCyanothece sp. (strain ATCC 51142)
Taxonomic identifieri43989 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
Proteomesi
  • UP000001203 Componenti: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Ribonuclease ZPRO_1000187948Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi43989.cce_4065.

Structurei

3D structure databases

ProteinModelPortaliB1WQW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiWYLVDCG.
OrthoDBiPOG091H07TH.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 2 hits.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WQW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITFLGTSS GVPTRSRNVS SVALRLPQRA EVWLFDCGEG TQHQLLRSDV
60 70 80 90 100
KISQITRIFV THMHGDHIYG LTGLLASCGL AGSGQPIEIY GPPELKDYLK
110 120 130 140 150
ACAKYSHFKL PHHIRFHPIH PGILYEDAEF SVSCNLLKHR IPAYGYRIAE
160 170 180 190 200
SDRPGRFNVE KAKSLGIPPG PVYGELKQGK TVTLPDGRNI RGQDLCGERE
210 220 230 240 250
TGRKVIYCTD TVFCEGAIAL SEDADVLIHE ATFAHQDAQL AFDRLHSTST
260 270 280 290 300
MAAQVALAAQ VKQLIMTHFS PRYAPGNALQ LDDLLQEARA IFPNTILARD
310
FMTYEVPRRS SD
Length:312
Mass (Da):34,613
Last modified:May 20, 2008 - v1
Checksum:i1A39D490D4D79D8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB53413.1.
RefSeqiWP_009543851.1. NC_010546.1.

Genome annotation databases

EnsemblBacteriaiACB53413; ACB53413; cce_4065.
KEGGicyt:cce_4065.
PATRICi21546492. VBICyaSp130209_4051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB53413.1.
RefSeqiWP_009543851.1. NC_010546.1.

3D structure databases

ProteinModelPortaliB1WQW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi43989.cce_4065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB53413; ACB53413; cce_4065.
KEGGicyt:cce_4065.
PATRICi21546492. VBICyaSp130209_4051.

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiWYLVDCG.
OrthoDBiPOG091H07TH.

Enzyme and pathway databases

BioCyciCSP43989:GKC8-4120-MONOMER.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 2 hits.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ_CYAA5
AccessioniPrimary (citable) accession number: B1WQW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.