B1WQL6 (B1WQL6_CYAA5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
EC=3.5.1.- HAMAP MF_00388

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase HAMAP MF_00388

Gene names

Name:	lpxC HAMAP MF_00388 EMBL ACB51727.1
Ordered Locus Names:	cce_2378

Organism

Cyanothece sp. (strain ATCC 51142) [Complete proteome] [HAMAP]

Taxonomic identifier

43989 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388 SAAS SAAS015870
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388 SAAS SAAS015870
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388 SAAS SAAS015870
Sequence similarities	Belongs to the LpxC family. HAMAP MF_00388

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00388 SAAS SAAS015870 Lipid synthesis
Molecular function	Hydrolase HAMAP MF_00388 SAAS SAAS015870
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1WQL6 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 5789867944BD10D4	FASTA	272	29,603
	10 20 30 40 50 60 MTSIIEKGFT VSGIGLHSGA KTQVHVLPDD RNQGRYFVRV DLPEKPMIPA TVSAVNQTLL 70 80 90 100 110 120 STELMADTAT VRTVEHLLAA LTGCGIENAC IEIDGPEVPL LDGSAKNWVD AIIASGLNPS 130 140 150 160 170 180 EMAVGSPVIE PVWVREGDAF VAAIPAPDIR FTYGIDFPYP AIGNQWVSWS PKTEPFQDFI 190 200 210 220 230 240 APARTFGFAD QIEQLKQAGL IKGGSLENAL ICDRSGWVNP PLRFDNEPVR HKLLDLIGDL 250 260 270 SLLGTIPQAH FLAYKASHKL HIQLADILYQ NK

References

[1]

"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C., Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K., Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B. Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008) [PubMed: 18812508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000806 Genomic DNA. Translation: ACB51727.1.
RefSeq	YP_001803793.1. NC_010546.1.
3D structure databases
ProteinModelPortal	B1WQL6.
ModBase	Search...
Protein-protein interaction databases
STRING	B1WQL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6169434.
GenomeReviews	Gene locus cce_2378 in contig CP000806_GR.
KEGG	cyt:cce_2378.
PATRIC	21543188. VBICyaSp130209_2416.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	B1WQL6.
ProtClustDB	PRK13186.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1WQL6_CYAA5

Accession

Primary (citable) accession number: B1WQL6

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)