Kctd7

Functionⁱ

May be involved in the control of excitability of cortical neurons.By similarity

GO - Biological processⁱ

cellular potassium ion homeostasis Source: Ensembl
glutamate homeostasis
Source: RGD
Inferred from sequence orthologyⁱ
- 27742667
membrane hyperpolarization Source: Ensembl
positive regulation of transporter activity Source: Ensembl
protein homooligomerization Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8951664. Neddylation. R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Reactomeⁱ

R-RNO-8951664. Neddylation.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BTB/POZ domain-containing protein KCTD7
Gene namesⁱ	Name:Kctd7
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 12

Organism-specific databases

Rat genome database More...RGDⁱ	1582914. Kctd7.

RGDⁱ

1582914. Kctd7.

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000369240	1 – 289	BTB/POZ domain-containing protein KCTD7Add BLAST		289

Proteomic databases

PaxDbⁱ	B1WC97.
PRIDEⁱ	B1WC97.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000042384.

Bgeeⁱ

ENSRNOG00000042384.

Interactionⁱ

Subunit structureⁱ

Interacts with CUL3.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1WC97.
SMRⁱ	B1WC97.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	53 – 141	BTBAdd BLAST		89

Phylogenomic databases

eggNOGⁱ	KOG2723. Eukaryota. ENOG410Z155. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119013.
HOGENOMⁱ	HOG000113201.
InParanoidⁱ	B1WC97.
KEGG Orthology (KO) More...KOⁱ	K21917.
OMAⁱ	HREAQYY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0X03.
PhylomeDBⁱ	B1WC97.
TreeFamⁱ	TF315332.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210. BTB/POZ_dom. IPR011333. SKP1/BTB/POZ_sf. IPR003131. T1-type_BTB.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214. BTB_2. 1 hit.
SMARTⁱ	View protein in SMART SM00225. BTB. 1 hit.
SUPFAMⁱ	SSF54695. SSF54695. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B1WC97-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVVVNGREPD SRHSDGAMSS SEAEDDFLEP ATPTATQAGH GLPLLPQEFP 
        60         70         80         90        100
EVVPLNIGGA HFTTRLSTLR RYEDTMLAAM FSGRHYIPTD SEGRYFIDRD 
       110        120        130        140        150
GTHFGDVLNF LRSGDLPPRE HVRAVHKEAQ YYAIGPLLEQ LENMQPLKGE 
       160        170        180        190        200
KVRQAFLGLM PYYKDHLERI VEIARLRAVQ RKARFAKLKV CVFKEEMPIT 
       210        220        230        240        250
PYECPLLNSL RFERSESDGQ LFEHHCEVDV SFGPWEAVAD VYDLLHCLVT 
       260        270        280 
DLSAQGLTVD HQCIGVCDKH LVNHYYCKRP IYEFKITWW

Length:289

Mass (Da):33,093

Last modified:May 20, 2008 - v1

Checksum:ⁱ6DA58790AB84B5FD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH473973 Genomic DNA. Translation: EDM13466.1. BC162055 mRNA. Translation: AAI62055.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001121666.1. NM_001128194.2.
UniGeneⁱ	Rn.103510.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000001198; ENSRNOP00000001198; ENSRNOG00000042384.
GeneIDⁱ	688993.
KEGGⁱ	rno:688993.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B1WC97	Q8BJK1 A0A1U7R3P3 UPI0003D70245 UPI000661E261 UPI0003513432 UPI000BB52A13 UPI00045D8FE4 UPI0004431263 UPI0004432C99 K7BCT2 +50	Mus musculus (Mouse) Mesocricetus auratus (Golden hamster) Cavia porcellus (Guinea pig) Enhydra lutris kenyoni Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Monodelphis domestica (Gray short-tailed opossum) Pan troglodytes (Chimpanzee) Sus scrofa (Pig) Aotus nancymaae (Ma's night monkey) Equus asinus (Donkey) (Equus africanus asinus) And more	289	UniRef90_Q8BJK1	Cluster: BTB/POZ domain-containing protein KCTD7	61

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B1WC97	Q96MP8 A0A024RDN7 H9EQG4 A0A2J8J7M6 A0A0D9S0A6 A0A2K6ED80 G3RF21 UPI00045E4BF1 A0A2K6A7B2 A0A2I3HB80 +217	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Pan troglodytes (Chimpanzee) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca nemestrina (Pig-tailed macaque) Gorilla gorilla gorilla (Western lowland gorilla) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Tarsius syrichta (Philippine tarsier) And more	289	UniRef50_Q96MP8	Cluster: BTB/POZ domain-containing protein KCTD7	228

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH473973 Genomic DNA. Translation: EDM13466.1. BC162055 mRNA. Translation: AAI62055.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001121666.1. NM_001128194.2.
UniGeneⁱ	Rn.103510.

3D structure databases

ProteinModelPortalⁱ	B1WC97.
SMRⁱ	B1WC97.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	B1WC97.
PRIDEⁱ	B1WC97.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000001198; ENSRNOP00000001198; ENSRNOG00000042384.
GeneIDⁱ	688993.
KEGGⁱ	rno:688993.

Organism-specific databases

CTDⁱ	154881.
Rat genome database More...RGDⁱ	1582914. Kctd7.

Phylogenomic databases

eggNOGⁱ	KOG2723. Eukaryota. ENOG410Z155. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119013.
HOGENOMⁱ	HOG000113201.
InParanoidⁱ	B1WC97.
KEGG Orthology (KO) More...KOⁱ	K21917.
OMAⁱ	HREAQYY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0X03.
PhylomeDBⁱ	B1WC97.
TreeFamⁱ	TF315332.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8951664. Neddylation. R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Reactomeⁱ

R-RNO-8951664. Neddylation.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B1WC97.

PROⁱ

PR:B1WC97.

Gene expression databases

Bgeeⁱ	ENSRNOG00000042384.

Bgeeⁱ

ENSRNOG00000042384.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210. BTB/POZ_dom. IPR011333. SKP1/BTB/POZ_sf. IPR003131. T1-type_BTB.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214. BTB_2. 1 hit.
SMARTⁱ	View protein in SMART SM00225. BTB. 1 hit.
SUPFAMⁱ	SSF54695. SSF54695. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCTD7_RAT
Accessionⁱ	B1WC97Primary (citable) accession number: B1WC97
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
	Last sequence update:	May 20, 2008
	Last modified:	February 28, 2018
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1WC97 (KCTD7_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

BTB/POZ domain-containing protein KCTD7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma membrane

Cytosol

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ