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Protein

WD repeat-containing and planar cell polarity effector protein fritz homolog

Gene

Wdpcp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing and planar cell polarity effector protein fritz homolog
Alternative name(s):
WD repeat-containing and planar cell polarity effector protein
Gene namesi
Name:Wdpcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309501. Wdpcp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004061961 – 726WD repeat-containing and planar cell polarity effector protein fritz homologAdd BLAST726

Proteomic databases

PaxDbiB1WC10.
PRIDEiB1WC10.

Interactioni

Subunit structurei

Interacts with C5orf42/JBTS17. Interacts with INTU and FUZ; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011567.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati305 – 343WD 1Add BLAST39
Repeati344 – 383WD 2Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat fritz family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IGAV. Eukaryota.
ENOG410Y1HY. LUCA.
HOGENOMiHOG000049175.
HOVERGENiHBG066656.
InParanoidiB1WC10.
PhylomeDBiB1WC10.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR024511. Frtz.
IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERiPTHR13667:SF6. PTHR13667:SF6. 1 hit.
PfamiView protein in Pfam
PF11768. Frtz. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WC10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFCLTELHL WSLKSTLHIA DRDIGVYQYY DKKDLPVSAA EHGNLEEKQR
60 70 80 90 100
LAESRDYPWT LKNRRPEKLR DSLKELEELM QNSQCVLCQW KSKHICQLLF
110 120 130 140 150
GSGVLVSLSL SGPQLEKVVI DRSLVGKLIS DTISDALLTD SFIILSFLAQ
160 170 180 190 200
NKLCFIQFAK KMDSLDVNKR LEKLSALDYK ISYHDIPGPA TRTVDRHLAI
210 220 230 240 250
NSTQDLAVCW WPLLSDDAWP WTPIASEKDR ANMLLLGFTQ GGLEVLSSVR
260 270 280 290 300
TEWNPLDVHF GTRQPYQVFT VECSFSVDQE PMADSCIYES VRNKLHCVSV
310 320 330 340 350
TRIPLRSKAI SCCKNSTEDK LIVGCEDSSV ILYEAHRGVT LLAQAELMPS
360 370 380 390 400
LISCHPSGAI LLVGSNQGEL QVFDIALSPI NIQLLAEDCL PKETLQFNKF
410 420 430 440 450
FDFSSSLVHM QWIAPPIVFQ KPKRGEICDL LFLRFNRGPL GVLLFKLGVL
460 470 480 490 500
RRGQLGLVDL IFQYIHCDEV YEAVSVLSSM NWDTLGQQCF ISMSTIVNHL
510 520 530 540 550
LRQRLTPERE AQLEASLGTF YAPARPLLDT TVLAYRDPVG TYARRLFHHL
560 570 580 590 600
LRYQRFEKAF LLAVDIGARD LFMDIHYLAL DMGELALAEV ARRRADDIDV
610 620 630 640 650
ESVCSGVELL GPLDRRDMLN EGFAGSALTP EGGNPFPDLL PSSGSTPKHT
660 670 680 690 700
IQQKIPNGPS NRRAIERKNE VMEETEEEEE EEEEAAACTD SSVATTWDAE
710 720
GELREDHRRQ DTEDVGSLRM VHFGLV
Length:726
Mass (Da):81,910
Last modified:May 20, 2008 - v1
Checksum:i4ADAD9735B02E641
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161962 mRNA. Translation: AAI61962.1.
RefSeqiNP_001121009.1. NM_001127537.1.
UniGeneiRn.6266.

Genome annotation databases

GeneIDi305552.
KEGGirno:305552.
UCSCiRGD:1309501. rat.

Similar proteinsi

Entry informationi

Entry nameiFRITZ_RAT
AccessioniPrimary (citable) accession number: B1WC10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: May 20, 2008
Last modified: May 10, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families