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Protein
Submitted name:

Hdac2 protein

Gene

Hdac2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateUniRule annotation1
Active sitei200Proton acceptorUniRule annotation1
Binding sitei208Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi235Divalent metal cationUniRule annotation1
Metal bindingi237Divalent metal cationUniRule annotation1
Metal bindingi323Divalent metal cationUniRule annotation1
Binding sitei362SubstrateUniRule annotation1

GO - Molecular functioni

  • core promoter binding Source: RGD
  • enzyme binding Source: RGD
  • heat shock protein binding Source: RGD
  • histone deacetylase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • transcription factor binding Source: RGD

GO - Biological processi

  • behavioral response to ethanol Source: RGD
  • cardiac muscle hypertrophy Source: RGD
  • cellular response to dopamine Source: RGD
  • cellular response to heat Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to retinoic acid Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • histone deacetylation Source: RGD
  • histone H3 deacetylation Source: RGD
  • negative regulation of dendritic spine development Source: RGD
  • negative regulation of DNA binding Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • negative regulation of peptidyl-lysine acetylation Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of epithelial to mesenchymal transition Source: RGD
  • positive regulation of interleukin-1 production Source: RGD
  • positive regulation of oligodendrocyte differentiation Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
  • response to amphetamine Source: RGD
  • response to caffeine Source: RGD
  • response to cocaine Source: RGD
  • response to drug Source: RGD
  • response to hyperoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nicotine Source: RGD

Keywordsi

LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hdac2 proteinImported
Gene namesi
Name:Hdac2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619976. Hdac2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2095943.

PTM / Processingi

Proteomic databases

PaxDbiB1WBY8.
PRIDEiB1WBY8.

Expressioni

Gene expression databases

GenevisibleiB1WBY8. RN.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • heat shock protein binding Source: RGD
  • transcription factor binding Source: RGD

Protein-protein interaction databases

IntActiB1WBY8. 1 interactor.
MINTiMINT-7138457.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 376Hist_deacetylInterPro annotationAdd BLAST290

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
KOiK06067.
PhylomeDBiB1WBY8.
TreeFamiTF106171.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Fragment.

B1WBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ALRSRALPAP ARRPAPGCPC CEGRRARRLP QPSCLAAGPR RARAAGGGAA
60 70 80 90 100
ARRRRPEPMA YSQGGGKKKV CYYYDGDIGN YYYGQGHPMK PHRIRMTHNL
110 120 130 140 150
LLNYGLYRKM EIYRPHKATA EEMTKYHSDE YIKFLRSIRP DNMSEYSKQM
160 170 180 190 200
QRFNVGEDCP VFDGLFEFCQ LSTGGSVAGA VKLNRQQTDM AVNWAGGLHH
210 220 230 240 250
AKKSEASGFC YVNDIVLAVL ELLKYHQRVL YIDIDIHHGD GVEEAFYTTD
260 270 280 290 300
RVMTVSFHKY GEYFPGTGDL RDIGAGKGKY YAVNFPMRDG IDDESYGQIF
310 320 330 340 350
KPIISKVMEM YQPSAVVLQC GADSLSGDRL GCFNLTVKGH AKCVEVVKTF
360 370 380 390 400
NLPLLMLGGG GYTIRNVARC WTYETAVALD CEIPNELPYN DYFEYFGPDF
410 420 430 440 450
KLHISPSNMT NQNTPEYMEK IKQRLFENLR MLPHAPGVQM QAIPEDAVHE
460 470 480 490 500
DSGDEDGEDP DKRISIRASD KRIACDEEFS DSEDEGEGGR RNVADHKKGA
510 520 530 540
KKARIEEDKK EAEDKRTDVK EEDKSKDNSG EKTDTKGAKS EQLNNP
Length:546
Mass (Da):61,422
Last modified:May 20, 2008 - v1
Checksum:iB57901BFDD8773A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161939 mRNA. Translation: AAI61939.1.
RefSeqiNP_445899.1. NM_053447.1.
UniGeneiRn.1797.

Genome annotation databases

GeneIDi84577.
KEGGirno:84577.

Similar proteinsi

Entry informationi

Entry nameiB1WBY8_RAT
AccessioniPrimary (citable) accession number: B1WBY8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)