Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hdac2 protein

Gene

Hdac2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateUniRule annotation1
Active sitei200Proton acceptorUniRule annotation1
Binding sitei208Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi235Divalent metal cationUniRule annotation1
Metal bindingi237Divalent metal cationUniRule annotation1
Metal bindingi323Divalent metal cationUniRule annotation1
Binding sitei362SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: RGD
  • behavioral response to ethanol Source: RGD
  • cardiac muscle cell development Source: RGD
  • cardiac muscle hypertrophy Source: RGD
  • cellular response to dopamine Source: RGD
  • cellular response to heat Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to retinoic acid Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • cellular response to trichostatin A Source: RGD
  • circadian regulation of gene expression Source: RGD
  • dendrite development Source: RGD
  • embryonic digit morphogenesis Source: RGD
  • epidermal cell differentiation Source: RGD
  • eyelid development in camera-type eye Source: RGD
  • fungiform papilla formation Source: RGD
  • hair follicle placode formation Source: RGD
  • hippocampus development Source: RGD
  • histone deacetylation Source: RGD
  • histone H3 deacetylation Source: RGD
  • histone H3-K27 methylation Source: RGD
  • histone H4 deacetylation Source: RGD
  • maintenance of chromatin silencing Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of canonical Wnt signaling pathway Source: RGD
  • negative regulation of cardiac muscle cell proliferation Source: RGD
  • negative regulation of dendritic spine development Source: RGD
  • negative regulation of DNA binding Source: RGD
  • negative regulation of DNA binding transcription factor activity Source: RGD
  • negative regulation of intrinsic apoptotic signaling pathway Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • negative regulation of peptidyl-lysine acetylation Source: RGD
  • negative regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • neuron differentiation Source: RGD
  • odontogenesis of dentin-containing tooth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of DNA binding transcription factor activity Source: RGD
  • positive regulation of epithelial to mesenchymal transition Source: RGD
  • positive regulation of interleukin-1 production Source: RGD
  • positive regulation of oligodendrocyte differentiation Source: RGD
  • positive regulation of proteolysis Source: RGD
  • positive regulation of receptor biosynthetic process Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
  • protein deacetylation Source: RGD
  • regulation of protein deacetylation Source: RGD
  • regulation of protein kinase B signaling Source: RGD
  • regulation of sarcomere organization Source: RGD
  • response to amphetamine Source: RGD
  • response to caffeine Source: RGD
  • response to cocaine Source: RGD
  • response to drug Source: RGD
  • response to hyperoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nicotine Source: RGD

Keywordsi

LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hdac2 proteinImported
Gene namesi
Name:Hdac2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619976 Hdac2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2095943

PTM / Processingi

Proteomic databases

PRIDEiB1WBY8

Expressioni

Gene expression databases

GenevisibleiB1WBY8 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiB1WBY8, 1 interactor
MINTiB1WBY8

Structurei

3D structure databases

SMRiB1WBY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 376Hist_deacetylInterPro annotationAdd BLAST290

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili502 – 522Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225180
HOVERGENiHBG057112
KOiK06067
PhylomeDBiB1WBY8
TreeFamiTF106171

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Fragment.

B1WBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ALRSRALPAP ARRPAPGCPC CEGRRARRLP QPSCLAAGPR RARAAGGGAA
60 70 80 90 100
ARRRRPEPMA YSQGGGKKKV CYYYDGDIGN YYYGQGHPMK PHRIRMTHNL
110 120 130 140 150
LLNYGLYRKM EIYRPHKATA EEMTKYHSDE YIKFLRSIRP DNMSEYSKQM
160 170 180 190 200
QRFNVGEDCP VFDGLFEFCQ LSTGGSVAGA VKLNRQQTDM AVNWAGGLHH
210 220 230 240 250
AKKSEASGFC YVNDIVLAVL ELLKYHQRVL YIDIDIHHGD GVEEAFYTTD
260 270 280 290 300
RVMTVSFHKY GEYFPGTGDL RDIGAGKGKY YAVNFPMRDG IDDESYGQIF
310 320 330 340 350
KPIISKVMEM YQPSAVVLQC GADSLSGDRL GCFNLTVKGH AKCVEVVKTF
360 370 380 390 400
NLPLLMLGGG GYTIRNVARC WTYETAVALD CEIPNELPYN DYFEYFGPDF
410 420 430 440 450
KLHISPSNMT NQNTPEYMEK IKQRLFENLR MLPHAPGVQM QAIPEDAVHE
460 470 480 490 500
DSGDEDGEDP DKRISIRASD KRIACDEEFS DSEDEGEGGR RNVADHKKGA
510 520 530 540
KKARIEEDKK EAEDKRTDVK EEDKSKDNSG EKTDTKGAKS EQLNNP
Length:546
Mass (Da):61,422
Last modified:May 20, 2008 - v1
Checksum:iB57901BFDD8773A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161939 mRNA Translation: AAI61939.1
RefSeqiNP_445899.1, NM_053447.1
UniGeneiRn.1797

Genome annotation databases

GeneIDi84577
KEGGirno:84577

Similar proteinsi

Entry informationi

Entry nameiB1WBY8_RAT
AccessioniPrimary (citable) accession number: B1WBY8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health