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Protein
Submitted name:

Cul1 protein

Gene

Cul1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1170546. Prolactin receptor signaling.
R-RNO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-RNO-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-RNO-195253. Degradation of beta-catenin by the destruction complex.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5610780. Degradation of GLI1 by the proteasome.
R-RNO-5610785. GLI3 is processed to GLI3R by the proteasome.
R-RNO-5676590. NIK-->noncanonical NF-kB signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-RNO-8951664. Neddylation.
R-RNO-917937. Iron uptake and transport.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Cul1 proteinImported
Submitted name:
Cullin 1Imported
Submitted name:
Cullin 1 (Predicted), isoform CRA_aImported
Gene namesi
Name:Cul1Imported
Synonyms:Cul1_predictedImported
ORF Names:rCG_28370Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1308157. Cul1.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSRNOG00000005310.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007620.

Structurei

3D structure databases

SMRiB1WBY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 644CULLIN_2InterPro annotationAdd BLAST228

Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2166. Eukaryota.
COG5647. LUCA.
GeneTreeiENSGT00760000119212.
HOGENOMiHOG000176713.
HOVERGENiHBG106177.
KOiK03347.
OMAiTTHKHIE.
TreeFamiTF101151.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiView protein in InterPro
IPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
SMARTiView protein in SMART
SM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEiView protein in PROSITE
PS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WBY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY
60 70 80 90 100
NYCTSVHQSN QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL
110 120 130 140 150
TNLLKDGEDL MDESVLKFYT QQWEDYRFSS KVLNGICAYL NRHWVRRECD
160 170 180 190 200
EGRKGIYEIY SLALVTWRDC LFRPLNKQVT NAVLKLIEKE RNGETINTRL
210 220 230 240 250
ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT ERFYTRESTE
260 270 280 290 300
FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL
310 320 330 340 350
EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA
360 370 380 390 400
AIEKCGEAAL NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG
410 420 430 440 450
RFINNNAVTK MAQSSSKSPE LLARYCDSLL KKSSKNPEEA ELEDTLNQVM
460 470 480 490 500
VVFKYIEDKD VFQKFYAKML AKRLVHQNSA SDDAEASMIS KLKQACGFEY
510 520 530 540 550
TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL SSGSWPFQQS
560 570 580 590 600
CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT
610 620 630 640 650
LQASTFQMAI LLQYNTEDAY TVQQLTDSTQ IKMDILAQVL QILLKSKLLV
660 670 680 690 700
LEDENANVDE VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH
710 720 730 740 750
KNIEEDRKLL IQAAIVRIMK MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK
760 770
KCIDILIEKE YLERVDGEKD TYSYLA
Length:776
Mass (Da):89,692
Last modified:May 20, 2008 - v1
Checksum:i3E1F8B63C6E498F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07060512 Genomic DNA. No translation available.
BC161932 mRNA. Translation: AAI61932.1.
CH473959 Genomic DNA. Translation: EDM15554.1.
CH473959 Genomic DNA. Translation: EDM15555.1.
RefSeqiNP_001102097.1. NM_001108627.2.
XP_006236473.1. XM_006236411.2.
UniGeneiRn.68078.

Genome annotation databases

EnsembliENSRNOT00000007620; ENSRNOP00000007620; ENSRNOG00000005310.
ENSRNOT00000085805; ENSRNOP00000074678; ENSRNOG00000005310.
GeneIDi362356.
KEGGirno:362356.
UCSCiRGD:1308157. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB1WBY1_RAT
AccessioniPrimary (citable) accession number: B1WBY1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported