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Protein

Armadillo repeat-containing protein 10

Gene

Armc10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 10
Gene namesi
Name:Armc10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1305915. Armc10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Armadillo repeat-containing protein 10PRO_0000346791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei48 – 481PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB1WBW4.
PRIDEiB1WBW4.

PTM databases

iPTMnetiB1WBW4.
PhosphoSiteiB1WBW4.

Expressioni

Gene expression databases

GenevisibleiB1WBW4. RN.

Interactioni

Subunit structurei

Interacts with the DNA-binding domain of p53/TP53.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042700.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati101 – 14343ARMAdd
BLAST

Sequence similaritiesi

Contains 1 ARM repeat.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiB1WBW4.
OMAiLHGEECA.
OrthoDBiEOG70PBZ0.
PhylomeDBiB1WBW4.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WBW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGARDVGWV AAGLVLGAGA CYCIYRLTRG PRRGGRRLRP SRSAEDLTEG
60 70 80 90 100
SYDAILSAEQ LEKLLYLLES TDDPIITEKA LVTLGNNAAF STNQAIIREL
110 120 130 140 150
GGIPIVGSKI NSLNQSIKEK ALNALNNLSV NVENQTKIKI YVRQVCEDVF
160 170 180 190 200
ADPLNSAVQL AALRLLTNMT VTNDYQHLLS NYITGLLHLL LIGNGSTKVQ
210 220 230 240 250
VLKLLLNLSE NPAMTEGLLS AQVDSSFLSL YDGQMANEIL LRALTLFQNI
260 270 280 290 300
NNCLRVEGRL ANQLPFAKGS LFFLLYGEEC AQKMKALACH PDVDVKEKAL

AIKPKF
Length:306
Mass (Da):33,422
Last modified:May 20, 2008 - v1
Checksum:iC650BA2C13ECDED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161913 mRNA. Translation: AAI61913.1.
RefSeqiNP_001100046.2. NM_001106576.2.
UniGeneiRn.2408.

Genome annotation databases

EnsembliENSRNOT00000044020; ENSRNOP00000042700; ENSRNOG00000012785.
GeneIDi296758.
KEGGirno:296758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161913 mRNA. Translation: AAI61913.1.
RefSeqiNP_001100046.2. NM_001106576.2.
UniGeneiRn.2408.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042700.

PTM databases

iPTMnetiB1WBW4.
PhosphoSiteiB1WBW4.

Proteomic databases

PaxDbiB1WBW4.
PRIDEiB1WBW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044020; ENSRNOP00000042700; ENSRNOG00000012785.
GeneIDi296758.
KEGGirno:296758.

Organism-specific databases

CTDi83787.
RGDi1305915. Armc10.

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiB1WBW4.
OMAiLHGEECA.
OrthoDBiEOG70PBZ0.
PhylomeDBiB1WBW4.
TreeFamiTF335652.

Miscellaneous databases

NextBioi641760.
PROiB1WBW4.

Gene expression databases

GenevisibleiB1WBW4. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARM10_RAT
AccessioniPrimary (citable) accession number: B1WBW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 20, 2008
Last modified: January 20, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.