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Protein

Serine/threonine-protein kinase SBK2

Gene

Sbk2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911ATPPROSITE-ProRule annotation
Active sitei183 – 1831Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 769ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK2 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 2
Gene namesi
Name:Sbk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1563279. Sbk2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Serine/threonine-protein kinase SBK2PRO_0000376932Add
BLAST

Proteomic databases

PaxDbiB1WBU5.
PRIDEiB1WBU5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055736.

Structurei

3D structure databases

ProteinModelPortaliB1WBU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 330269Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
InParanoidiB1WBU5.
KOiK08858.
OMAiWRQREGE.
OrthoDBiEOG7SBNPJ.
PhylomeDBiB1WBU5.
TreeFamiTF326736.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WBU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKQSEDRP MEVAAVEDGG DEGLGGLTVE ELQQGQEAAL ALEDMMALSA
60 70 80 90 100
QTLVRTEVEE LYEEVRPLGQ GRFGRVLLVT HRQKGTPLAL KQLPKHSTSL
110 120 130 140 150
RSFLYEFCVG LSLGTHPAIV AAYGIGIESA NSYSFLTEPV LHGDLITFIK
160 170 180 190 200
PKVGLPQPAV QRCAAQLASA LEHIHSHGLV YRDLKPENVL VCDPACQRVK
210 220 230 240 250
LTDFGHTRPR GTMLRLTGPP IPYTAPELCA PPPLPEGLPI QPALDAWALG
260 270 280 290 300
VLIFCLLTGY FPWDQPLVEV DPFFEDFLIW QASGQPQDRP QPWYNLSPAA
310 320 330 340 350
DTLLWGLLDP HPRKRNPVSS IKSYLGQPWK QREEGAEELT KELREDGSRG
360
GQEAAKGEQP AC
Length:362
Mass (Da):39,773
Last modified:May 20, 2008 - v1
Checksum:iD7FAB1FD9A219CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474075 Genomic DNA. Translation: EDL75876.1.
BC161893 mRNA. Translation: AAI61893.1.
RefSeqiNP_001121011.1. NM_001127539.2.
UniGeneiRn.201731.

Genome annotation databases

EnsembliENSRNOT00000058956; ENSRNOP00000055736; ENSRNOG00000038625.
GeneIDi691411.
KEGGirno:691411.
UCSCiRGD:1563279. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474075 Genomic DNA. Translation: EDL75876.1.
BC161893 mRNA. Translation: AAI61893.1.
RefSeqiNP_001121011.1. NM_001127539.2.
UniGeneiRn.201731.

3D structure databases

ProteinModelPortaliB1WBU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055736.

Proteomic databases

PaxDbiB1WBU5.
PRIDEiB1WBU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058956; ENSRNOP00000055736; ENSRNOG00000038625.
GeneIDi691411.
KEGGirno:691411.
UCSCiRGD:1563279. rat.

Organism-specific databases

CTDi646643.
RGDi1563279. Sbk2.

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
InParanoidiB1WBU5.
KOiK08858.
OMAiWRQREGE.
OrthoDBiEOG7SBNPJ.
PhylomeDBiB1WBU5.
TreeFamiTF326736.

Miscellaneous databases

PROiB1WBU5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiSBK2_RAT
AccessioniPrimary (citable) accession number: B1WBU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.