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Protein

Serine/threonine-protein kinase SBK2

Gene

Sbk2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91ATPPROSITE-ProRule annotation1
Active sitei183Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 76ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK2 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 2
Gene namesi
Name:Sbk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1563279. Sbk2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003769321 – 362Serine/threonine-protein kinase SBK2Add BLAST362

Proteomic databases

PaxDbiB1WBU5.
PRIDEiB1WBU5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000038625.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055736.

Structurei

3D structure databases

ProteinModelPortaliB1WBU5.
SMRiB1WBU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 330Protein kinasePROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
InParanoidiB1WBU5.
KOiK08858.
OMAiWRQREGE.
OrthoDBiEOG091G0QNH.
PhylomeDBiB1WBU5.
TreeFamiTF326736.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WBU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKQSEDRP MEVAAVEDGG DEGLGGLTVE ELQQGQEAAL ALEDMMALSA
60 70 80 90 100
QTLVRTEVEE LYEEVRPLGQ GRFGRVLLVT HRQKGTPLAL KQLPKHSTSL
110 120 130 140 150
RSFLYEFCVG LSLGTHPAIV AAYGIGIESA NSYSFLTEPV LHGDLITFIK
160 170 180 190 200
PKVGLPQPAV QRCAAQLASA LEHIHSHGLV YRDLKPENVL VCDPACQRVK
210 220 230 240 250
LTDFGHTRPR GTMLRLTGPP IPYTAPELCA PPPLPEGLPI QPALDAWALG
260 270 280 290 300
VLIFCLLTGY FPWDQPLVEV DPFFEDFLIW QASGQPQDRP QPWYNLSPAA
310 320 330 340 350
DTLLWGLLDP HPRKRNPVSS IKSYLGQPWK QREEGAEELT KELREDGSRG
360
GQEAAKGEQP AC
Length:362
Mass (Da):39,773
Last modified:May 20, 2008 - v1
Checksum:iD7FAB1FD9A219CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474075 Genomic DNA. Translation: EDL75876.1.
BC161893 mRNA. Translation: AAI61893.1.
RefSeqiNP_001121011.1. NM_001127539.2.
XP_017445240.1. XM_017589751.1.
UniGeneiRn.201731.

Genome annotation databases

EnsembliENSRNOT00000058956; ENSRNOP00000055736; ENSRNOG00000038625.
GeneIDi691411.
KEGGirno:691411.
UCSCiRGD:1563279. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474075 Genomic DNA. Translation: EDL75876.1.
BC161893 mRNA. Translation: AAI61893.1.
RefSeqiNP_001121011.1. NM_001127539.2.
XP_017445240.1. XM_017589751.1.
UniGeneiRn.201731.

3D structure databases

ProteinModelPortaliB1WBU5.
SMRiB1WBU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055736.

Proteomic databases

PaxDbiB1WBU5.
PRIDEiB1WBU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058956; ENSRNOP00000055736; ENSRNOG00000038625.
GeneIDi691411.
KEGGirno:691411.
UCSCiRGD:1563279. rat.

Organism-specific databases

CTDi646643.
RGDi1563279. Sbk2.

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
InParanoidiB1WBU5.
KOiK08858.
OMAiWRQREGE.
OrthoDBiEOG091G0QNH.
PhylomeDBiB1WBU5.
TreeFamiTF326736.

Miscellaneous databases

PROiPR:B1WBU5.

Gene expression databases

BgeeiENSRNOG00000038625.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSBK2_RAT
AccessioniPrimary (citable) accession number: B1WBU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 20, 2008
Last modified: March 15, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.