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B1WBQ7

- B1WBQ7_RAT

UniProt

B1WBQ7 - B1WBQ7_RAT

Protein
Submitted name:

DNA mismatch repair protein Msh2

Gene

Msh2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ADP binding Source: Ensembl
    2. ATPase activity Source: Ensembl
    3. ATP binding Source: InterPro
    4. centromeric DNA binding Source: Ensembl
    5. dinucleotide repeat insertion binding Source: Ensembl
    6. four-way junction DNA binding Source: Ensembl
    7. magnesium ion binding Source: Ensembl
    8. oxidized purine DNA binding Source: Ensembl
    9. single guanine insertion binding Source: Ensembl
    10. single-stranded DNA binding Source: Ensembl
    11. single thymine insertion binding Source: Ensembl

    GO - Biological processi

    1. B cell differentiation Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. determination of adult lifespan Source: Ensembl
    4. double-strand break repair Source: Ensembl
    5. germ cell development Source: Ensembl
    6. intra-S DNA damage checkpoint Source: Ensembl
    7. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. isotype switching Source: Ensembl
    10. maintenance of DNA repeat elements Source: Ensembl
    11. male gonad development Source: Ensembl
    12. mismatch repair Source: Ensembl
    13. negative regulation of DNA recombination Source: Ensembl
    14. negative regulation of neuron apoptotic process Source: Ensembl
    15. oxidative phosphorylation Source: Ensembl
    16. positive regulation of helicase activity Source: Ensembl
    17. postreplication repair Source: Ensembl
    18. response to UV-B Source: Ensembl
    19. response to X-ray Source: Ensembl
    20. somatic hypermutation of immunoglobulin genes Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DNA mismatch repair protein Msh2Imported
    Submitted name:
    Msh2 proteinImported
    Submitted name:
    MutS homolog 2 (E. coli)Imported
    Gene namesi
    Name:Msh2Imported
    ORF Names:rCG_62190Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi620786. Msh2.

    Subcellular locationi

    GO - Cellular componenti

    1. MutSalpha complex Source: Ensembl
    2. MutSbeta complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriB1WBQ7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021538.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074867.
    HOVERGENiHBG006399.
    OMAiLNKCRTP.
    OrthoDBiEOG76DTRW.
    TreeFamiTF351780.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR011184. DNA_mismatch_repair_MSH2.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005813. MSH2. 1 hit.
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1WBQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVQPKETLQ LEGAAEVGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA    50
    LLAAREVFKT QGVIKYMGPA GAKTLQTVVL SKMNFESFVK DLLLVRHYRV 100
    EVYKNKAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSTSIGIMGI 150
    KLSTVDGQRQ VGVGYVDSTQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECI 200
    LPGGETAGDM GKLRQVIQRG GILITERKRI DFSTKDIYQD LNRLLKGRKG 250
    EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM 300
    KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVSQWIKQPL 350
    MDKNRIEERL NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN 400
    LQDCYRLYQG VNQLPNVIQA LEKYQGRHQA LLLAVFVTPL TDLRSDFSKF 450
    QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREVMDGLEK KMQSTLISAA 500
    RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK 550
    FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA 600
    HLDAVVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDDVAF 650
    IPNDVHFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA 700
    EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL 750
    GRGTSTYDGF GLAWAISEYI ATKIGAFCMF ATHFHELTAL ASQIPTVNNL 800
    HVTALTTEET LTMLYQVKTG VCDQSFGIHV AELANFPRHV IECAKQKALE 850
    LEEFQSIGTS QGHDETQPAA KRRCLEREQG EKIILEFLSK VKQVPFTDLS 900
    EESVSVKLKQ LKAEVLAKNN SFVNEIISRV KAP 933
    Length:933
    Mass (Da):104,154
    Last modified:May 20, 2008 - v1
    Checksum:iD9580B553D9C7188
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06041790 Genomic DNA. No translation available.
    AABR06041791 Genomic DNA. No translation available.
    AABR06041792 Genomic DNA. No translation available.
    BC161846 mRNA. Translation: AAI61846.1.
    CH473947 Genomic DNA. Translation: EDM02635.1.
    UniGeneiRn.3174.

    Genome annotation databases

    EnsembliENSRNOT00000021538; ENSRNOP00000021538; ENSRNOG00000015796.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06041790 Genomic DNA. No translation available.
    AABR06041791 Genomic DNA. No translation available.
    AABR06041792 Genomic DNA. No translation available.
    BC161846 mRNA. Translation: AAI61846.1 .
    CH473947 Genomic DNA. Translation: EDM02635.1 .
    UniGenei Rn.3174.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021538 ; ENSRNOP00000021538 ; ENSRNOG00000015796 .

    Organism-specific databases

    RGDi 620786. Msh2.

    Phylogenomic databases

    GeneTreei ENSGT00550000074867.
    HOVERGENi HBG006399.
    OMAi LNKCRTP.
    OrthoDBi EOG76DTRW.
    TreeFami TF351780.

    Miscellaneous databases

    NextBioi 35564859.
    PROi B1WBQ7.

    Gene expression databases

    Genevestigatori B1WBQ7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR011184. DNA_mismatch_repair_MSH2.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005813. MSH2. 1 hit.
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiB1WBQ7_RAT
    AccessioniPrimary (citable) accession number: B1WBQ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3