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Protein

DNA mismatch repair protein

Gene

Msh2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the post-replicative DNA mismatch repair system (MMR).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA repairUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-RNO-5358606. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair proteinUniRule annotation
Gene namesi
Name:Msh2Imported
ORF Names:rCG_62190Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620786. Msh2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000015796.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini743 – 759DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili553 – 576Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0219. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000074867.
HOVERGENiHBG006399.
OMAiGDFYTAH.
OrthoDBiEOG091G03SA.
TreeFamiTF351780.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
InterProiView protein in InterPro
IPR011184. DNA_mismatch_repair_Msh2.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR036187. DNA_mismatch_repair_MutS_sf.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
IPR036678. MutS_con_dom_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11361:SF35. PTHR11361:SF35. 1 hit.
PfamiView protein in Pfam
PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiView protein in SMART
SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WBQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQPKETLQ LEGAAEVGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA
60 70 80 90 100
LLAAREVFKT QGVIKYMGPA GAKTLQTVVL SKMNFESFVK DLLLVRHYRV
110 120 130 140 150
EVYKNKAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSTSIGIMGI
160 170 180 190 200
KLSTVDGQRQ VGVGYVDSTQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECI
210 220 230 240 250
LPGGETAGDM GKLRQVIQRG GILITERKRI DFSTKDIYQD LNRLLKGRKG
260 270 280 290 300
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM
310 320 330 340 350
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVSQWIKQPL
360 370 380 390 400
MDKNRIEERL NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN
410 420 430 440 450
LQDCYRLYQG VNQLPNVIQA LEKYQGRHQA LLLAVFVTPL TDLRSDFSKF
460 470 480 490 500
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREVMDGLEK KMQSTLISAA
510 520 530 540 550
RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
560 570 580 590 600
FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
610 620 630 640 650
HLDAVVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDDVAF
660 670 680 690 700
IPNDVHFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA
710 720 730 740 750
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL
760 770 780 790 800
GRGTSTYDGF GLAWAISEYI ATKIGAFCMF ATHFHELTAL ASQIPTVNNL
810 820 830 840 850
HVTALTTEET LTMLYQVKTG VCDQSFGIHV AELANFPRHV IECAKQKALE
860 870 880 890 900
LEEFQSIGTS QGHDETQPAA KRRCLEREQG EKIILEFLSK VKQVPFTDLS
910 920 930
EESVSVKLKQ LKAEVLAKNN SFVNEIISRV KAP
Length:933
Mass (Da):104,154
Last modified:May 20, 2008 - v1
Checksum:iD9580B553D9C7188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062843 Genomic DNA. No translation available.
BC161846 mRNA. Translation: AAI61846.1.
CH473947 Genomic DNA. Translation: EDM02635.1.
UniGeneiRn.3174.

Genome annotation databases

EnsembliENSRNOT00000021538; ENSRNOP00000021538; ENSRNOG00000015796.

Similar proteinsi

Entry informationi

Entry nameiB1WBQ7_RAT
AccessioniPrimary (citable) accession number: B1WBQ7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported