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B1WBQ7

- B1WBQ7_RAT

UniProt

B1WBQ7 - B1WBQ7_RAT

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Protein
Submitted name:

DNA mismatch repair protein Msh2

Gene

Msh2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATPase activity Source: Ensembl
  3. ATP binding Source: InterPro
  4. centromeric DNA binding Source: Ensembl
  5. dinucleotide repeat insertion binding Source: Ensembl
  6. four-way junction DNA binding Source: Ensembl
  7. guanine/thymine mispair binding Source: Ensembl
  8. magnesium ion binding Source: Ensembl
  9. oxidized purine DNA binding Source: Ensembl
  10. single guanine insertion binding Source: Ensembl
  11. single-stranded DNA binding Source: Ensembl
  12. single thymine insertion binding Source: Ensembl

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. determination of adult lifespan Source: Ensembl
  4. double-strand break repair Source: Ensembl
  5. germ cell development Source: Ensembl
  6. intra-S DNA damage checkpoint Source: Ensembl
  7. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. isotype switching Source: Ensembl
  10. maintenance of DNA repeat elements Source: Ensembl
  11. male gonad development Source: Ensembl
  12. mismatch repair Source: Ensembl
  13. negative regulation of DNA recombination Source: Ensembl
  14. negative regulation of neuron apoptotic process Source: Ensembl
  15. oxidative phosphorylation Source: Ensembl
  16. positive regulation of helicase activity Source: Ensembl
  17. postreplication repair Source: Ensembl
  18. response to UV-B Source: Ensembl
  19. response to X-ray Source: Ensembl
  20. somatic hypermutation of immunoglobulin genes Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_235056. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
REACT_260603. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Names & Taxonomyi

Protein namesi
Submitted name:
DNA mismatch repair protein Msh2Imported
Submitted name:
Msh2 proteinImported
Submitted name:
MutS homolog 2 (E. coli)Imported
Gene namesi
Name:Msh2Imported
ORF Names:rCG_62190Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi620786. Msh2.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: Ensembl
  2. MutSalpha complex Source: Ensembl
  3. MutSbeta complex Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB1WBQ7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021538.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074867.
HOVERGENiHBG006399.
OMAiLNKCRTP.
OrthoDBiEOG76DTRW.
TreeFamiTF351780.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MSH2.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WBQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVQPKETLQ LEGAAEVGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA
60 70 80 90 100
LLAAREVFKT QGVIKYMGPA GAKTLQTVVL SKMNFESFVK DLLLVRHYRV
110 120 130 140 150
EVYKNKAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSTSIGIMGI
160 170 180 190 200
KLSTVDGQRQ VGVGYVDSTQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECI
210 220 230 240 250
LPGGETAGDM GKLRQVIQRG GILITERKRI DFSTKDIYQD LNRLLKGRKG
260 270 280 290 300
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM
310 320 330 340 350
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVSQWIKQPL
360 370 380 390 400
MDKNRIEERL NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN
410 420 430 440 450
LQDCYRLYQG VNQLPNVIQA LEKYQGRHQA LLLAVFVTPL TDLRSDFSKF
460 470 480 490 500
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREVMDGLEK KMQSTLISAA
510 520 530 540 550
RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
560 570 580 590 600
FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
610 620 630 640 650
HLDAVVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDDVAF
660 670 680 690 700
IPNDVHFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA
710 720 730 740 750
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL
760 770 780 790 800
GRGTSTYDGF GLAWAISEYI ATKIGAFCMF ATHFHELTAL ASQIPTVNNL
810 820 830 840 850
HVTALTTEET LTMLYQVKTG VCDQSFGIHV AELANFPRHV IECAKQKALE
860 870 880 890 900
LEEFQSIGTS QGHDETQPAA KRRCLEREQG EKIILEFLSK VKQVPFTDLS
910 920 930
EESVSVKLKQ LKAEVLAKNN SFVNEIISRV KAP
Length:933
Mass (Da):104,154
Last modified:May 20, 2008 - v1
Checksum:iD9580B553D9C7188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06041790 Genomic DNA. No translation available.
AABR06041791 Genomic DNA. No translation available.
AABR06041792 Genomic DNA. No translation available.
BC161846 mRNA. Translation: AAI61846.1.
CH473947 Genomic DNA. Translation: EDM02635.1.
UniGeneiRn.3174.

Genome annotation databases

EnsembliENSRNOT00000021538; ENSRNOP00000021538; ENSRNOG00000015796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06041790 Genomic DNA. No translation available.
AABR06041791 Genomic DNA. No translation available.
AABR06041792 Genomic DNA. No translation available.
BC161846 mRNA. Translation: AAI61846.1 .
CH473947 Genomic DNA. Translation: EDM02635.1 .
UniGenei Rn.3174.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021538 ; ENSRNOP00000021538 ; ENSRNOG00000015796 .

Organism-specific databases

RGDi 620786. Msh2.

Phylogenomic databases

GeneTreei ENSGT00550000074867.
HOVERGENi HBG006399.
OMAi LNKCRTP.
OrthoDBi EOG76DTRW.
TreeFami TF351780.

Enzyme and pathway databases

Reactomei REACT_235056. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
REACT_260603. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Miscellaneous databases

NextBioi 35564859.
PROi B1WBQ7.

Gene expression databases

Genevestigatori B1WBQ7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR011184. DNA_mismatch_repair_MSH2.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
PIRSFi PIRSF005813. MSH2. 1 hit.
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB1WBQ7_RAT
AccessioniPrimary (citable) accession number: B1WBQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3