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B1WBQ7

- B1WBQ7_RAT

UniProt

B1WBQ7 - B1WBQ7_RAT

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Protein
Submitted name: DNA mismatch repair protein Msh2
Gene
Msh2, rCG_62190
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATP binding Source: InterPro
  3. ATPase activity Source: Ensembl
  4. centromeric DNA binding Source: Ensembl
  5. dinucleotide repeat insertion binding Source: Ensembl
  6. four-way junction DNA binding Source: Ensembl
  7. magnesium ion binding Source: Ensembl
  8. oxidized purine DNA binding Source: Ensembl
  9. single guanine insertion binding Source: Ensembl
  10. single thymine insertion binding Source: Ensembl
  11. single-stranded DNA binding Source: Ensembl

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. determination of adult lifespan Source: Ensembl
  4. double-strand break repair Source: Ensembl
  5. germ cell development Source: Ensembl
  6. in utero embryonic development Source: Ensembl
  7. intra-S DNA damage checkpoint Source: Ensembl
  8. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  9. isotype switching Source: Ensembl
  10. maintenance of DNA repeat elements Source: Ensembl
  11. male gonad development Source: Ensembl
  12. mismatch repair Source: Ensembl
  13. negative regulation of DNA recombination Source: Ensembl
  14. negative regulation of neuron apoptotic process Source: Ensembl
  15. oxidative phosphorylation Source: Ensembl
  16. positive regulation of helicase activity Source: Ensembl
  17. postreplication repair Source: Ensembl
  18. response to UV-B Source: Ensembl
  19. response to X-ray Source: Ensembl
  20. somatic hypermutation of immunoglobulin genes Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
DNA mismatch repair protein Msh2Imported
Submitted name:
Msh2 proteinImported
Submitted name:
MutS homolog 2 (E. coli)Imported
Gene namesi
Name:Msh2Imported
ORF Names:rCG_62190Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi620786. Msh2.

Subcellular locationi

GO - Cellular componenti

  1. MutSalpha complex Source: Ensembl
  2. MutSbeta complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB1WBQ7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021538.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074867.
HOVERGENiHBG006399.
OMAiLNKCRTP.
OrthoDBiEOG76DTRW.
TreeFamiTF351780.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MSH2.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WBQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MAVQPKETLQ LEGAAEVGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA    50
LLAAREVFKT QGVIKYMGPA GAKTLQTVVL SKMNFESFVK DLLLVRHYRV 100
EVYKNKAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSTSIGIMGI 150
KLSTVDGQRQ VGVGYVDSTQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECI 200
LPGGETAGDM GKLRQVIQRG GILITERKRI DFSTKDIYQD LNRLLKGRKG 250
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM 300
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVSQWIKQPL 350
MDKNRIEERL NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN 400
LQDCYRLYQG VNQLPNVIQA LEKYQGRHQA LLLAVFVTPL TDLRSDFSKF 450
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREVMDGLEK KMQSTLISAA 500
RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK 550
FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA 600
HLDAVVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDDVAF 650
IPNDVHFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA 700
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL 750
GRGTSTYDGF GLAWAISEYI ATKIGAFCMF ATHFHELTAL ASQIPTVNNL 800
HVTALTTEET LTMLYQVKTG VCDQSFGIHV AELANFPRHV IECAKQKALE 850
LEEFQSIGTS QGHDETQPAA KRRCLEREQG EKIILEFLSK VKQVPFTDLS 900
EESVSVKLKQ LKAEVLAKNN SFVNEIISRV KAP 933
Length:933
Mass (Da):104,154
Last modified:May 20, 2008 - v1
Checksum:iD9580B553D9C7188
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06041790 Genomic DNA. No translation available.
AABR06041791 Genomic DNA. No translation available.
AABR06041792 Genomic DNA. No translation available.
BC161846 mRNA. Translation: AAI61846.1.
CH473947 Genomic DNA. Translation: EDM02635.1.
UniGeneiRn.3174.

Genome annotation databases

EnsembliENSRNOT00000021538; ENSRNOP00000021538; ENSRNOG00000015796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06041790 Genomic DNA. No translation available.
AABR06041791 Genomic DNA. No translation available.
AABR06041792 Genomic DNA. No translation available.
BC161846 mRNA. Translation: AAI61846.1 .
CH473947 Genomic DNA. Translation: EDM02635.1 .
UniGenei Rn.3174.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021538 ; ENSRNOP00000021538 ; ENSRNOG00000015796 .

Organism-specific databases

RGDi 620786. Msh2.

Phylogenomic databases

GeneTreei ENSGT00550000074867.
HOVERGENi HBG006399.
OMAi LNKCRTP.
OrthoDBi EOG76DTRW.
TreeFami TF351780.

Miscellaneous databases

NextBioi 35564859.
PROi B1WBQ7.

Gene expression databases

Genevestigatori B1WBQ7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR011184. DNA_mismatch_repair_MSH2.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
PIRSFi PIRSF005813. MSH2. 1 hit.
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB1WBQ7_RAT
AccessioniPrimary (citable) accession number: B1WBQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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