B1WAX6 (TIGAR_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable fructose-2,6-bisphosphatase TIGAR
EC=3.1.3.46

Alternative name(s):
TP53-induced glycolysis and apoptosis regulator

Gene names

Name:

tigar

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by tp53 By similarity.
Catalytic activity	Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
Sequence similarities	Belongs to the phosphoglycerate mutase family.
Caution	Not expected to have any kinase activity.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	fructose-2,6-bisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Probable fructose-2,6-bisphosphatase TIGAR		PRO_0000363070
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	198	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1WAX6 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: C98131CCDF93B3FA	FASTA	275	30,738
	10 20 30 40 50 60 MARFALTIVR HGETRYNKEK LLQGQGIDEP LSEIGFKQAD AVGRFLSNVR FTHVFSSDLI 70 80 90 100 110 120 RAKQTACAIM ENNKISEDIK IIYDRRLRER KYGDAEGRPL SELKVMAKKA GDQCPSYTPP 130 140 150 160 170 180 GGETLEQVRA RAKDFFEYLC RLVLEESSAK EQSELGASGM GGVTSADLGP FVNHNKEPAE 190 200 210 220 230 240 LGESRDVTVH ASVLLVSHGA YMRNWIKYLV EDLQFTFPPE LKKSRELPVS PNTGISHFIV 250 260 270 TVSSATPRKP EIQCVCINLH SHLSDINADT SHYQV

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC161536 mRNA. Translation: AAI61536.1.
RefSeq	NP_001120569.1. NM_001127097.1.
UniGene	Str.52599.
3D structure databases
ProteinModelPortal	B1WAX6.
ModBase	Search...
Protein-protein interaction databases
STRING	B1WAX6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100145723.
KEGG	xtr:100145723.
Organism-specific databases
CTD	57103.
Xenbase	XB-GENE-1008472. c12orf5.
Phylogenomic databases
eggNOG	veNOG14020.
GeneTree	ENSGT00390000013224.
HOVERGEN	HBG108569.
Gene expression databases
Bgee	B1WAX6.
Family and domain databases
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. [Graphical view]
KO	K14634.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TIGAR_XENTR

Accession

Primary (citable) accession number: B1WAX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 20, 2008
Last modified:	November 16, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program