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B1WAU7

- B1WAU7_XENTR

UniProt

B1WAU7 - B1WAU7_XENTR

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Protein
Submitted name:

Tgfbr1 protein

Gene

tgfbr1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204688. Downregulation of TGF-beta receptor signaling.
REACT_209755. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
REACT_213810. TGFBR1 KD Mutants in Cancer.
REACT_214617. SMAD2/3 MH2 Domain Mutants in Cancer.
REACT_217082. TGFBR2 Kinase Domain Mutants in Cancer.
REACT_221188. TGF-beta receptor signaling activates SMADs.
REACT_225235. TGFBR1 LBD Mutants in Cancer.
REACT_227154. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Names & Taxonomyi

Protein namesi
Submitted name:
Tgfbr1 proteinImported
Gene namesi
Name:tgfbr1Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiB1WAU7.
ExpressionAtlasiB1WAU7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000050561.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG054502.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1WAU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SISSPCLRLP RLIVLLLIAL ARWAEALICH CEQCANRTCM TDGLCLVNVL
60 70 80 90 100
IQDGKVTHNS LCIADSERVP RDRPFMCFST STNGIYHNVE CCQTDFCNKK
110 120 130 140 150
LPAPSTSPSP RPPTNLGPVE LAAVIAGPVC LVCILLMLVL YICHNRTVIH
160 170 180 190 200
HRVPNDEDPS LDRPFISEGT TLKDLIYDMT TSGSGSGLPL LVQRTIARTI
210 220 230 240 250
VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR
260 270 280 290 300
HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMLKL
310 320 330 340 350
SLSTASGLAH LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA
360 370 380 390 400
VRHDSATDTI DIAPNHRVGT KRYMAPEVLD DSINMKHFES FKRADIYAMG
410 420 430 440 450
LVFWEIARRC SIGGIHEDYQ LPYYDLVPSD PSVEEMKKVV CEQKLRPNIP
460 470 480 490
NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTLSQL SQQEGLKM
Length:498
Mass (Da):55,998
Last modified:May 20, 2008 - v1
Checksum:i076A7DD8B4ED09CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161506 mRNA. Translation: AAI61506.1.
UniGeneiStr.42236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161506 mRNA. Translation: AAI61506.1 .
UniGenei Str.42236.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000050561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG054502.

Enzyme and pathway databases

Reactomei REACT_204688. Downregulation of TGF-beta receptor signaling.
REACT_209755. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
REACT_213810. TGFBR1 KD Mutants in Cancer.
REACT_214617. SMAD2/3 MH2 Domain Mutants in Cancer.
REACT_217082. TGFBR2 Kinase Domain Mutants in Cancer.
REACT_221188. TGF-beta receptor signaling activates SMADs.
REACT_225235. TGFBR1 LBD Mutants in Cancer.
REACT_227154. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Gene expression databases

Bgeei B1WAU7.
ExpressionAtlasi B1WAU7. baseline.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Whole embryoImported.

Entry informationi

Entry nameiB1WAU7_XENTR
AccessioniPrimary (citable) accession number: B1WAU7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)