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Protein

Serine/threonine-protein kinase receptor

Gene

tgfbr1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase receptorUniRule annotation (EC:2.7.11.30UniRule annotation)
Gene namesi
Name:tgfbr1Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei121 – 143HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500277181327 – 498Serine/threonine-protein kinase receptorSequence analysisAdd BLAST472

Proteomic databases

PaxDbiB1WAU7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 199GSInterPro annotationAdd BLAST30
Domaini200 – 490Protein kinaseInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
HOVERGENiHBG054502.
OrthoDBiEOG091G0BIU.

Family and domain databases

InterProiView protein in InterPro
IPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiView protein in Pfam
PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
PRINTSiPR00653. ACTIVIN2R.
SMARTiView protein in SMART
SM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Fragment.

B1WAU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SISSPCLRLP RLIVLLLIAL ARWAEALICH CEQCANRTCM TDGLCLVNVL
60 70 80 90 100
IQDGKVTHNS LCIADSERVP RDRPFMCFST STNGIYHNVE CCQTDFCNKK
110 120 130 140 150
LPAPSTSPSP RPPTNLGPVE LAAVIAGPVC LVCILLMLVL YICHNRTVIH
160 170 180 190 200
HRVPNDEDPS LDRPFISEGT TLKDLIYDMT TSGSGSGLPL LVQRTIARTI
210 220 230 240 250
VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR
260 270 280 290 300
HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMLKL
310 320 330 340 350
SLSTASGLAH LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA
360 370 380 390 400
VRHDSATDTI DIAPNHRVGT KRYMAPEVLD DSINMKHFES FKRADIYAMG
410 420 430 440 450
LVFWEIARRC SIGGIHEDYQ LPYYDLVPSD PSVEEMKKVV CEQKLRPNIP
460 470 480 490
NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTLSQL SQQEGLKM
Length:498
Mass (Da):55,998
Last modified:May 20, 2008 - v1
Checksum:i076A7DD8B4ED09CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161506 mRNA. Translation: AAI61506.1.
UniGeneiStr.42236.

Similar proteinsi

Entry informationi

Entry nameiB1WAU7_XENTR
AccessioniPrimary (citable) accession number: B1WAU7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)