Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B1WAU7

- B1WAU7_XENTR

UniProt

B1WAU7 - B1WAU7_XENTR

Protein
Submitted name:

Tgfbr1 protein

Gene

tgfbr1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. receptor signaling protein serine/threonine kinase activity Source: InterPro
    3. transforming growth factor beta-activated receptor activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204688. Downregulation of TGF-beta receptor signaling.
    REACT_209755. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
    REACT_213810. TGFBR1 KD Mutants in Cancer.
    REACT_214617. SMAD2/3 MH2 Domain Mutants in Cancer.
    REACT_217082. TGFBR2 Kinase Domain Mutants in Cancer.
    REACT_221188. TGF-beta receptor signaling activates SMADs.
    REACT_225235. TGFBR1 LBD Mutants in Cancer.
    REACT_227154. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tgfbr1 proteinImported
    Gene namesi
    Name:tgfbr1Imported
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    BgeeiB1WAU7.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000050561.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG054502.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B1WAU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    SISSPCLRLP RLIVLLLIAL ARWAEALICH CEQCANRTCM TDGLCLVNVL    50
    IQDGKVTHNS LCIADSERVP RDRPFMCFST STNGIYHNVE CCQTDFCNKK 100
    LPAPSTSPSP RPPTNLGPVE LAAVIAGPVC LVCILLMLVL YICHNRTVIH 150
    HRVPNDEDPS LDRPFISEGT TLKDLIYDMT TSGSGSGLPL LVQRTIARTI 200
    VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR 250
    HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMLKL 300
    SLSTASGLAH LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA 350
    VRHDSATDTI DIAPNHRVGT KRYMAPEVLD DSINMKHFES FKRADIYAMG 400
    LVFWEIARRC SIGGIHEDYQ LPYYDLVPSD PSVEEMKKVV CEQKLRPNIP 450
    NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTLSQL SQQEGLKM 498
    Length:498
    Mass (Da):55,998
    Last modified:May 20, 2008 - v1
    Checksum:i076A7DD8B4ED09CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161506 mRNA. Translation: AAI61506.1.
    UniGeneiStr.42236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161506 mRNA. Translation: AAI61506.1 .
    UniGenei Str.42236.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000050561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG054502.

    Enzyme and pathway databases

    Reactomei REACT_204688. Downregulation of TGF-beta receptor signaling.
    REACT_209755. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
    REACT_213810. TGFBR1 KD Mutants in Cancer.
    REACT_214617. SMAD2/3 MH2 Domain Mutants in Cancer.
    REACT_217082. TGFBR2 Kinase Domain Mutants in Cancer.
    REACT_221188. TGF-beta receptor signaling activates SMADs.
    REACT_225235. TGFBR1 LBD Mutants in Cancer.
    REACT_227154. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

    Gene expression databases

    Bgeei B1WAU7.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Whole embryoImported.

    Entry informationi

    Entry nameiB1WAU7_XENTR
    AccessioniPrimary (citable) accession number: B1WAU7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)