SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B1WAP7

- DVL3_XENTR

UniProt

B1WAP7 - DVL3_XENTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Segment polarity protein dishevelled homolog DVL-3

Gene
dvl3
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the signal transduction pathway mediated by multiple Wnt genes By similarity. Required in ciliogenesis for the docking of basal bodies to the apical plasma membrane By similarity.By similarity

GO - Molecular functioni

  1. beta-catenin binding Source: BHF-UCL
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. ciliary basal body organization Source: UniProtKB
  2. cilium assembly Source: UniProtKB
  3. intracellular signal transduction Source: InterPro
  4. multicellular organismal development Source: UniProtKB-KW
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cilium biogenesis/degradation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_202457. TCF dependent signaling in response to WNT.
REACT_210066. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218073. degradation of DVL.
REACT_227893. WNT mediated activation of DVL.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name:
Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene namesi
Name:dvl3
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-977362. dvl3.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Segment polarity protein dishevelled homolog DVL-3PRO_0000354667Add
BLAST

Expressioni

Gene expression databases

BgeeiB1WAP7.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037606.

Structurei

3D structure databases

ProteinModelPortaliB1WAP7.
SMRiB1WAP7. Positions 246-334, 405-495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282DIXAdd
BLAST
Domaini248 – 33386PDZAdd
BLAST
Domaini421 – 49575DEPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 64620His-richAdd
BLAST

Sequence similaritiesi

Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG322275.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WAP7-1 [UniParc]FASTAAdd to Basket

« Hide

MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNVLNKP NYKFFFKSMD    50
DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADNQSDLP 100
PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA HRERPRRKET 150
PEHATRLNGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF 200
SNSTEQSSAS RLMRRHKRRR RKPKAPRIER SSSFSSITDS TMSLNIITVT 250
LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ 300
VNDTNFENMS NDDAVRVLRE IVHKPGPITL TVAKCWDPSP RNCFTLPRSE 350
PIRPIDPAAW VSHTAAMTGS YPAYGMSPSM STITSTSSSI TSSIPETERF 400
DDFQLSIHSD MVTIVKAMRS PESGLEVRDR MWLKITIPNA FIGSDVVDWL 450
YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM 500
ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG 550
FPDPAYSYGG GSAGSQHSEG SRSSGSNRSS TEKRKEREAK GGDTKSGGSG 600
SESDHTTRSS VRRERAASER SVPASEHSHR SHHSIAHSIR SHHTHHSFGP 650
PGIPPLYGAP MMMMPAPASV IGPPGAPPSR DLASVPPELT ASRQSFRMAM 700
GNPTKNSGVF DFL 713
Length:713
Mass (Da):78,314
Last modified:May 20, 2008 - v1
Checksum:iE43625C6BC9E79A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC161453 mRNA. Translation: AAI61453.1.
RefSeqiNP_001116929.1. NM_001123457.1.
UniGeneiStr.43617.

Genome annotation databases

GeneIDi100144702.
KEGGixtr:100144702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC161453 mRNA. Translation: AAI61453.1 .
RefSeqi NP_001116929.1. NM_001123457.1.
UniGenei Str.43617.

3D structure databases

ProteinModelPortali B1WAP7.
SMRi B1WAP7. Positions 246-334, 405-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000037606.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100144702.
KEGGi xtr:100144702.

Organism-specific databases

CTDi 1857.
Xenbasei XB-GENE-977362. dvl3.

Phylogenomic databases

eggNOGi NOG322275.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
KOi K02353.

Enzyme and pathway databases

Reactomei REACT_202457. TCF dependent signaling in response to WNT.
REACT_210066. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218073. degradation of DVL.
REACT_227893. WNT mediated activation of DVL.

Gene expression databases

Bgeei B1WAP7.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.

Entry informationi

Entry nameiDVL3_XENTR
AccessioniPrimary (citable) accession number: B1WAP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi