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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

dvl3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the signal transduction pathway mediated by multiple Wnt genes. Required in ciliogenesis for the docking of basal bodies to the apical plasma membrane.By similarity

GO - Molecular functioni

  1. beta-catenin binding Source: BHF-UCL

GO - Biological processi

  1. ciliary basal body organization Source: UniProtKB
  2. cilium assembly Source: UniProtKB
  3. intracellular signal transduction Source: InterPro
  4. multicellular organismal development Source: UniProtKB-KW
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cilium biogenesis/degradation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_291604. WNT mediated activation of DVL.
REACT_294758. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_327615. degradation of DVL.
REACT_328157. TCF dependent signaling in response to WNT.
REACT_338918. negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3By similarity
Short name:
Dishevelled-3By similarity
Alternative name(s):
DSH homolog 3
Gene namesi
Name:dvl3By similarity
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-977362. dvl3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Segment polarity protein dishevelled homolog DVL-3PRO_0000354667Add
BLAST

Expressioni

Gene expression databases

BgeeiB1WAP7.
ExpressionAtlasiB1WAP7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037606.

Structurei

3D structure databases

ProteinModelPortaliB1WAP7.
SMRiB1WAP7. Positions 246-334, 405-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
BLAST
Domaini248 – 33386PDZPROSITE-ProRule annotationAdd
BLAST
Domaini421 – 49575DEPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 64620His-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the DSH family.Sequence Analysis
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322275.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiB1WAP7.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WAP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNVLNKP NYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADNQSDLP
110 120 130 140 150
PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA HRERPRRKET
160 170 180 190 200
PEHATRLNGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF
210 220 230 240 250
SNSTEQSSAS RLMRRHKRRR RKPKAPRIER SSSFSSITDS TMSLNIITVT
260 270 280 290 300
LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ
310 320 330 340 350
VNDTNFENMS NDDAVRVLRE IVHKPGPITL TVAKCWDPSP RNCFTLPRSE
360 370 380 390 400
PIRPIDPAAW VSHTAAMTGS YPAYGMSPSM STITSTSSSI TSSIPETERF
410 420 430 440 450
DDFQLSIHSD MVTIVKAMRS PESGLEVRDR MWLKITIPNA FIGSDVVDWL
460 470 480 490 500
YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM
510 520 530 540 550
ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG
560 570 580 590 600
FPDPAYSYGG GSAGSQHSEG SRSSGSNRSS TEKRKEREAK GGDTKSGGSG
610 620 630 640 650
SESDHTTRSS VRRERAASER SVPASEHSHR SHHSIAHSIR SHHTHHSFGP
660 670 680 690 700
PGIPPLYGAP MMMMPAPASV IGPPGAPPSR DLASVPPELT ASRQSFRMAM
710
GNPTKNSGVF DFL
Length:713
Mass (Da):78,314
Last modified:May 20, 2008 - v1
Checksum:iE43625C6BC9E79A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161453 mRNA. Translation: AAI61453.1.
RefSeqiNP_001116929.1. NM_001123457.1.
UniGeneiStr.43617.

Genome annotation databases

GeneIDi100144702.
KEGGixtr:100144702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161453 mRNA. Translation: AAI61453.1.
RefSeqiNP_001116929.1. NM_001123457.1.
UniGeneiStr.43617.

3D structure databases

ProteinModelPortaliB1WAP7.
SMRiB1WAP7. Positions 246-334, 405-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100144702.
KEGGixtr:100144702.

Organism-specific databases

CTDi1857.
XenbaseiXB-GENE-977362. dvl3.

Phylogenomic databases

eggNOGiNOG322275.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiB1WAP7.
KOiK02353.

Enzyme and pathway databases

ReactomeiREACT_291604. WNT mediated activation of DVL.
REACT_294758. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_327615. degradation of DVL.
REACT_328157. TCF dependent signaling in response to WNT.
REACT_338918. negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Gene expression databases

BgeeiB1WAP7.
ExpressionAtlasiB1WAP7. baseline.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: GastrulaImported.

Entry informationi

Entry nameiDVL3_XENTR
AccessioniPrimary (citable) accession number: B1WAP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: April 1, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.