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B1WAP7 (DVL3_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Segment polarity protein dishevelled homolog DVL-3

Short name=Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene names
Name:dvl3
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length713 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the signal transduction pathway mediated by multiple Wnt genes By similarity. Required in ciliogenesis for the docking of basal bodies to the apical plasma membrane By similarity. UniProtKB Q6DKE2

Subcellular location

Cytoplasm By similarity UniProtKB O14641.

Sequence similarities

Belongs to the DSH family.

Contains 1 DEP domain.

Contains 1 DIX domain.

Contains 1 PDZ (DHR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 713713Segment polarity protein dishevelled homolog DVL-3
PRO_0000354667

Regions

Domain1 – 8282DIX
Domain248 – 33386PDZ
Domain421 – 49575DEP
Compositional bias627 – 64620His-rich

Sequences

Sequence LengthMass (Da)Tools
B1WAP7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: E43625C6BC9E79A4

FASTA71378,314
        10         20         30         40         50         60 
MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNVLNKP NYKFFFKSMD DDFGVVKEEI 

        70         80         90        100        110        120 
SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADNQSDLP PPIERTGGIG DSRPPSFHPN 

       130        140        150        160        170        180 
TRGSQENLDN ETETDSVVSA HRERPRRKET PEHATRLNGT SKMERRRDTG GYESSSTLMS 

       190        200        210        220        230        240 
SELDSTSFFD SDEDDSTSRF SNSTEQSSAS RLMRRHKRRR RKPKAPRIER SSSFSSITDS 

       250        260        270        280        290        300 
TMSLNIITVT LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ 

       310        320        330        340        350        360 
VNDTNFENMS NDDAVRVLRE IVHKPGPITL TVAKCWDPSP RNCFTLPRSE PIRPIDPAAW 

       370        380        390        400        410        420 
VSHTAAMTGS YPAYGMSPSM STITSTSSSI TSSIPETERF DDFQLSIHSD MVTIVKAMRS 

       430        440        450        460        470        480 
PESGLEVRDR MWLKITIPNA FIGSDVVDWL YHHVEGFTDR REARKYASNL LKAGYIRHTV 

       490        500        510        520        530        540 
NKITFSEQCY YIFGDLCGNM ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP 

       550        560        570        580        590        600 
LPHPYSPHPG FPDPAYSYGG GSAGSQHSEG SRSSGSNRSS TEKRKEREAK GGDTKSGGSG 

       610        620        630        640        650        660 
SESDHTTRSS VRRERAASER SVPASEHSHR SHHSIAHSIR SHHTHHSFGP PGIPPLYGAP 

       670        680        690        700        710 
MMMMPAPASV IGPPGAPPSR DLASVPPELT ASRQSFRMAM GNPTKNSGVF DFL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC161453 mRNA. Translation: AAI61453.1.
RefSeqNP_001116929.1. NM_001123457.1.
UniGeneStr.43617.

3D structure databases

ProteinModelPortalB1WAP7.
SMRB1WAP7. Positions 246-334, 405-495.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000037606.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100144702.
KEGGxtr:100144702.

Organism-specific databases

CTD1857.
XenbaseXB-GENE-977362. dvl3.

Phylogenomic databases

eggNOGNOG322275.
HOGENOMHOG000017084.
HOVERGENHBG005542.
KOK02353.

Gene expression databases

BgeeB1WAP7.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSPR01760. DISHEVELLED.
SMARTSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDVL3_XENTR
AccessionPrimary (citable) accession number: B1WAP7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families