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B1WAP7

- DVL3_XENTR

UniProt

B1WAP7 - DVL3_XENTR

Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

dvl3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    May play a role in the signal transduction pathway mediated by multiple Wnt genes. Required in ciliogenesis for the docking of basal bodies to the apical plasma membrane.By similarity

    GO - Molecular functioni

    1. beta-catenin binding Source: BHF-UCL
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. ciliary basal body organization Source: UniProtKB
    2. cilium assembly Source: UniProtKB
    3. intracellular signal transduction Source: InterPro
    4. multicellular organismal development Source: UniProtKB-KW
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cilium biogenesis/degradation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_202457. TCF dependent signaling in response to WNT.
    REACT_210066. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218073. degradation of DVL.
    REACT_227893. WNT mediated activation of DVL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-3By similarity
    Short name:
    Dishevelled-3By similarity
    Alternative name(s):
    DSH homolog 3
    Gene namesi
    Name:dvl3By similarity
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-977362. dvl3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 713713Segment polarity protein dishevelled homolog DVL-3PRO_0000354667Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiB1WAP7.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000037606.

    Structurei

    3D structure databases

    ProteinModelPortaliB1WAP7.
    SMRiB1WAP7. Positions 246-334, 405-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini248 – 33386PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini421 – 49575DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi627 – 64620His-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DSH family.Sequence Analysis
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322275.
    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    KOiK02353.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008342. Dishevelled_3.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF6. PTHR10878:SF6. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1WAP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNVLNKP NYKFFFKSMD    50
    DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADNQSDLP 100
    PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA HRERPRRKET 150
    PEHATRLNGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF 200
    SNSTEQSSAS RLMRRHKRRR RKPKAPRIER SSSFSSITDS TMSLNIITVT 250
    LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ 300
    VNDTNFENMS NDDAVRVLRE IVHKPGPITL TVAKCWDPSP RNCFTLPRSE 350
    PIRPIDPAAW VSHTAAMTGS YPAYGMSPSM STITSTSSSI TSSIPETERF 400
    DDFQLSIHSD MVTIVKAMRS PESGLEVRDR MWLKITIPNA FIGSDVVDWL 450
    YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM 500
    ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG 550
    FPDPAYSYGG GSAGSQHSEG SRSSGSNRSS TEKRKEREAK GGDTKSGGSG 600
    SESDHTTRSS VRRERAASER SVPASEHSHR SHHSIAHSIR SHHTHHSFGP 650
    PGIPPLYGAP MMMMPAPASV IGPPGAPPSR DLASVPPELT ASRQSFRMAM 700
    GNPTKNSGVF DFL 713
    Length:713
    Mass (Da):78,314
    Last modified:May 20, 2008 - v1
    Checksum:iE43625C6BC9E79A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161453 mRNA. Translation: AAI61453.1.
    RefSeqiNP_001116929.1. NM_001123457.1.
    UniGeneiStr.43617.

    Genome annotation databases

    GeneIDi100144702.
    KEGGixtr:100144702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161453 mRNA. Translation: AAI61453.1 .
    RefSeqi NP_001116929.1. NM_001123457.1.
    UniGenei Str.43617.

    3D structure databases

    ProteinModelPortali B1WAP7.
    SMRi B1WAP7. Positions 246-334, 405-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000037606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100144702.
    KEGGi xtr:100144702.

    Organism-specific databases

    CTDi 1857.
    Xenbasei XB-GENE-977362. dvl3.

    Phylogenomic databases

    eggNOGi NOG322275.
    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    KOi K02353.

    Enzyme and pathway databases

    Reactomei REACT_202457. TCF dependent signaling in response to WNT.
    REACT_210066. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218073. degradation of DVL.
    REACT_227893. WNT mediated activation of DVL.

    Gene expression databases

    Bgeei B1WAP7.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008342. Dishevelled_3.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF6. PTHR10878:SF6. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: GastrulaImported.

    Entry informationi

    Entry nameiDVL3_XENTR
    AccessioniPrimary (citable) accession number: B1WAP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3