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Protein

Catalase-peroxidase

Gene

katG

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei118 – 1181Transition state stabilizerUniRule annotation
Active sitei122 – 1221Proton acceptorUniRule annotation
Metal bindingi285 – 2851Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-6473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:SGR_6387
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Catalase-peroxidasePRO_0000354939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki121 ↔ 244Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-270)UniRule annotation
Cross-linki244 ↔ 270Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-121)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_6387.

Structurei

3D structure databases

ProteinModelPortaliB1W5Q9.
SMRiB1W5Q9. Positions 46-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1W5Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENHESHVF DPVTPDSPET AVPEVPGAQA AGCPVAHGRA PHPTQGGGNR
60 70 80 90 100
QWWPDRLNLK ILAKNPAVAN PLGGDFDYAA AFRGLDLPAV KRDIAEVLTT
110 120 130 140 150
SQDWWPADFG NYGPLMIRMA WHSAGTYRIS DGRGGAGAGQ QRFAPLNSWP
160 170 180 190 200
DNGNLDKARR LLWPVKKKYG QALSWADLLI LTGNVALETM GFKTFGFAGG
210 220 230 240 250
REDVWESEED VYWGPETTWL DDERYTGDRE LENPLGAVQM GLIYVNPEGP
260 270 280 290 300
NGNPDPVAAA RDIRETFRRM AMNDEETVAL IAGGHTFGKT HGAGPAESVG
310 320 330 340 350
ADPEGAPLEE QGLGWRSSYR SGKGGDAITS GLEVTWTSTP TRWGNEFFHN
360 370 380 390 400
LFAYEYELTK SPAGAHQWIA KDAEATIPDA HDASKKQKPQ MLTTDLSLRF
410 420 430 440 450
DPAYEQISRR FHENPEEFAD AFARAWYKLT HRDMGPVQRY LGPEVPSEVL
460 470 480 490 500
LWQDPLPART GEPLDAAEIA ALKEQVLATD LTVAQLVSAA WASAASFRGS
510 520 530 540 550
DKRGGANGAR VRLEPQRGWE ANDPDELAQV LRALEGVKES FDAKGGKQVS
560 570 580 590 600
LADLIVLAGG AAVEQAAKDA GVEVEVPFTP GRVDAAQDQT DVESFAALEP
610 620 630 640 650
AYDGFRNYVG KAARLPAEYL LLDRANLLTL SAPETTVLVG GLRVLGANTG
660 670 680 690 700
GSKHGVLTDR PGTLTNDFFV NLLDLGITWK STSSAQDEFE ARDASGKVKW
710 720 730 740 750
TGTRADLVFG SNSELRALAE VYAGDDARQK FVTDFVAAWS KVMDLDRFDL

V
Length:751
Mass (Da):81,589
Last modified:May 20, 2008 - v1
Checksum:i3B7A2ED2878BC8F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG23216.1.
RefSeqiWP_012381903.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG23216; BAG23216; SGR_6387.
GeneIDi6209390.
KEGGisgr:SGR_6387.
PATRICi23759637. VBIStrGri32265_6547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG23216.1.
RefSeqiWP_012381903.1. NC_010572.1.

3D structure databases

ProteinModelPortaliB1W5Q9.
SMRiB1W5Q9. Positions 46-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_6387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG23216; BAG23216; SGR_6387.
GeneIDi6209390.
KEGGisgr:SGR_6387.
PATRICi23759637. VBIStrGri32265_6547.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-6473-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_STRGG
AccessioniPrimary (citable) accession number: B1W5Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.