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B1W5J2

- DNLI_STRGG

UniProt

B1W5J2 - DNLI_STRGG

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Protein
Probable DNA ligase
Gene
lig, SGR_6320
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATP By similarity
Active sitei210 – 2101N6-AMP-lysine intermediate By similarity
Binding sitei215 – 2151ATP By similarity
Binding sitei230 – 2301ATP By similarity
Binding sitei259 – 2591ATP By similarity
Binding sitei299 – 2991ATP By similarity
Binding sitei377 – 3771ATP By similarity
Binding sitei383 – 3831ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-6406-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:SGR_6320
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Probable DNA ligaseUniRule annotation
PRO_0000365241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_6320.

Structurei

3D structure databases

ProteinModelPortaliB1W5J2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1W5J2-1 [UniParc]FASTAAdd to Basket

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MLLAELAQVS LEVAATSARS RKTALLAGLF RNAGPEDVPV VIPYLAGRLP    50
QGRIGVGWRS LGEPVEPACD PTLTVTGVDA ELTALAATSG PGSQARRRER 100
LRTLFAAATA DEQRFLRALL TGEVRQGALD AVAADALAHA AGAPPADVRR 150
AVMLAGSLQD VATVLLADGP GALADFRLTV GRPVQPMLAR SAASVGEALD 200
KLGPCAVEEK LDGIRVQVHR DGERIRAYTR TLDDITDRLP ELVSAVAALH 250
ARRFVLDGEL IALGEDGRPR PFQETASRVG SRRDVAGAAA HVPVVPVFFD 300
ALRVDGEDLL DRPFADRHAA LARLLPDDLR VRRTVVADPD APEARAAADA 350
FLAATLERGH EGVVVKDLAA AYSAGRRGAS WLKVKPVHTL DLVVLAVERG 400
SGRRTGKLSN LHLGARRPDG TFAMLGKTFK GLTDALLDWQ TARLRELATD 450
DDGHVVTVRP ELVVEIAYDG LQRSTRYPAG VTLRFARVLR YREDKTAREA 500
DTVETVLSRQ R 511
Length:511
Mass (Da):54,767
Last modified:May 20, 2008 - v1
Checksum:i715B6B5D62E79FDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG23149.1.
RefSeqiYP_001827832.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG23149; BAG23149; SGR_6320.
GeneIDi6211366.
KEGGisgr:SGR_6320.
PATRICi23759499. VBIStrGri32265_6478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG23149.1 .
RefSeqi YP_001827832.1. NC_010572.1.

3D structure databases

ProteinModelPortali B1W5J2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455632.SGR_6320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG23149 ; BAG23149 ; SGR_6320 .
GeneIDi 6211366.
KEGGi sgr:SGR_6320.
PATRICi 23759499. VBIStrGri32265_6478.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci SGRI455632:GD3A-6406-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350.

Entry informationi

Entry nameiDNLI_STRGG
AccessioniPrimary (citable) accession number: B1W5J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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