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B1W4P7 (UPPP_STRGG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SGR_6235
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197414

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane261 – 28121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1W4P7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 0425E33FB14E1C2E

FASTA29031,359
        10         20         30         40         50         60 
MSWFESFVLG LVQGLTEFLP ISSSAHLRLT AAFAGWHDPG AAFTAISQIG TEAAVLIYFR 

        70         80         90        100        110        120 
KDIARILSAW FRSLTDRSMR GDHDAQMGWL VIVGSIPIGV LGITLKDQIE GPFRDLRLIA 

       130        140        150        160        170        180 
TTLIVMGIVL GVADRLAARD ETGGKHRVVK ERKTLKDLGV KDGLIYGFCQ AMALIPGVSR 

       190        200        210        220        230        240 
SGATISGGLL MGYTRESAAR YSFLLAIPAV LASGAYELKD VGEGHVSWGP TIFATLVAFF 

       250        260        270        280        290 
VGYAVIAWFM KFITTKSFMP FVIYRILLGV VLFILIWAGV LSPHAGESAG 

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009493 Genomic DNA. Translation: BAG23064.1.
RefSeqYP_001827747.1. NC_010572.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING455632.SGR_6235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG23064; BAG23064; SGR_6235.
GeneID6209742.
KEGGsgr:SGR_6235.
PATRIC23759331. VBIStrGri32265_6394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAIEGPFRD.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSGRI455632:GD3A-6321-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_STRGG
AccessionPrimary (citable) accession number: B1W4P7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families