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B1W4G3

- GCSP_STRGG

UniProt

B1W4G3 - GCSP_STRGG

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, SGR_6151
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-6237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:SGR_6151
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi455632.SGR_6151.

Structurei

3D structure databases

ProteinModelPortaliB1W4G3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B1W4G3-1 [UniParc]FASTAAdd to Basket

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MTPRRTPLSQ LEQGIPFEQR HIGPDAEAQA KMLAQVGYGS LDELTAAAVP    50
DVIKSAEALN LPSARTEAEV LAELRSLADR NQVLAPMIGL GYYGTFTPPV 100
ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTMVAEL TGLPTSGASL 150
LDEGTAAAEA MALSRRVGKV KKGVFLVDAD TLPQTVAVIE TRAEPTGVEV 200
VVADLSDGIP AEIAERGVFG VLLQYPGASG AVRAIEPVIE QAHELGAIVT 250
VAADLLALTL LTSPGALGAD IAVGTTQRFG VPMGFGGPHA GFMAVREKFA 300
RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM 350
AGMYAVYHGP DGLRTIARRT HRFAAILADG LRSAGVDVVH GAFFDTLTVR 400
VPGKAAGIVA EARERGVNLR LVDADHVSIA CDETTTRSQI SAVWAAFGAE 450
GDIEALDAAV ADALPEGLLR SDDILTHPVF HQHRSETAML RYLRKLADRD 500
YALDRGMIPL GSCTMKLNAT AEMESITWPE FGALHPFAPA DQAQGFLTLI 550
RELEERLAEV TGYDAVSIQP NAGSQGEFAG LLAVRAYHRA NGDDQRTVCL 600
IPSSAHGTNA ASAVMAGMKV VVVKTADDGE VDIADLRAKI EQHRDELAVL 650
MITYPSTHGV FEEHVAEICG EVHDAGGQVY VDGANLNALV GLAKPGKFGG 700
DVSHLNLHKT FCIPHGGGGP GVGPVGVRAH LAPYLPNHPL QPAAGPETGV 750
GPISAAPWGS AGILPISWAY VRLMGGEGLK RATQVAVLAA NYIAKRLEPH 800
FPILYNGPAG LVAHECIVDL RPISKATGVS IDDVAKRLID YGFHSPTMSF 850
PVAGTLMIEP TESEDLAELD RFCDTMIAIR AEIEKVASGE WSADDNPLSN 900
APHTAAALGG DWEHGYSREE AVFPAGVSAA DKYWPPVRRI DGAFGDRNLV 950
CSCPPLDAYD D 961
Length:961
Mass (Da):102,006
Last modified:May 20, 2008 - v1
Checksum:i819593B6B7225401
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG22980.1.
RefSeqiYP_001827663.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG22980; BAG22980; SGR_6151.
GeneIDi6209942.
KEGGisgr:SGR_6151.
PATRICi23759159. VBIStrGri32265_6308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG22980.1 .
RefSeqi YP_001827663.1. NC_010572.1.

3D structure databases

ProteinModelPortali B1W4G3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455632.SGR_6151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG22980 ; BAG22980 ; SGR_6151 .
GeneIDi 6209942.
KEGGi sgr:SGR_6151.
PATRICi 23759159. VBIStrGri32265_6308.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SGRI455632:GD3A-6237-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350.

Entry informationi

Entry nameiGCSP_STRGG
AccessioniPrimary (citable) accession number: B1W4G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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