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B1W4G3

- GCSP_STRGG

UniProt

B1W4G3 - GCSP_STRGG

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSGRI455632:GD3A-6237-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:SGR_6151
    OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
    Taxonomic identifieri455632 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001685: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_1000132458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi455632.SGR_6151.

    Structurei

    3D structure databases

    ProteinModelPortaliB1W4G3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1W4G3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPRRTPLSQ LEQGIPFEQR HIGPDAEAQA KMLAQVGYGS LDELTAAAVP    50
    DVIKSAEALN LPSARTEAEV LAELRSLADR NQVLAPMIGL GYYGTFTPPV 100
    ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTMVAEL TGLPTSGASL 150
    LDEGTAAAEA MALSRRVGKV KKGVFLVDAD TLPQTVAVIE TRAEPTGVEV 200
    VVADLSDGIP AEIAERGVFG VLLQYPGASG AVRAIEPVIE QAHELGAIVT 250
    VAADLLALTL LTSPGALGAD IAVGTTQRFG VPMGFGGPHA GFMAVREKFA 300
    RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM 350
    AGMYAVYHGP DGLRTIARRT HRFAAILADG LRSAGVDVVH GAFFDTLTVR 400
    VPGKAAGIVA EARERGVNLR LVDADHVSIA CDETTTRSQI SAVWAAFGAE 450
    GDIEALDAAV ADALPEGLLR SDDILTHPVF HQHRSETAML RYLRKLADRD 500
    YALDRGMIPL GSCTMKLNAT AEMESITWPE FGALHPFAPA DQAQGFLTLI 550
    RELEERLAEV TGYDAVSIQP NAGSQGEFAG LLAVRAYHRA NGDDQRTVCL 600
    IPSSAHGTNA ASAVMAGMKV VVVKTADDGE VDIADLRAKI EQHRDELAVL 650
    MITYPSTHGV FEEHVAEICG EVHDAGGQVY VDGANLNALV GLAKPGKFGG 700
    DVSHLNLHKT FCIPHGGGGP GVGPVGVRAH LAPYLPNHPL QPAAGPETGV 750
    GPISAAPWGS AGILPISWAY VRLMGGEGLK RATQVAVLAA NYIAKRLEPH 800
    FPILYNGPAG LVAHECIVDL RPISKATGVS IDDVAKRLID YGFHSPTMSF 850
    PVAGTLMIEP TESEDLAELD RFCDTMIAIR AEIEKVASGE WSADDNPLSN 900
    APHTAAALGG DWEHGYSREE AVFPAGVSAA DKYWPPVRRI DGAFGDRNLV 950
    CSCPPLDAYD D 961
    Length:961
    Mass (Da):102,006
    Last modified:May 20, 2008 - v1
    Checksum:i819593B6B7225401
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG22980.1.
    RefSeqiYP_001827663.1. NC_010572.1.

    Genome annotation databases

    EnsemblBacteriaiBAG22980; BAG22980; SGR_6151.
    GeneIDi6209942.
    KEGGisgr:SGR_6151.
    PATRICi23759159. VBIStrGri32265_6308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG22980.1 .
    RefSeqi YP_001827663.1. NC_010572.1.

    3D structure databases

    ProteinModelPortali B1W4G3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455632.SGR_6151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG22980 ; BAG22980 ; SGR_6151 .
    GeneIDi 6209942.
    KEGGi sgr:SGR_6151.
    PATRICi 23759159. VBIStrGri32265_6308.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SGRI455632:GD3A-6237-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
      Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
      J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 4626 / NBRC 13350.

    Entry informationi

    Entry nameiGCSP_STRGG
    AccessioniPrimary (citable) accession number: B1W4G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3