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B1W4G3 (GCSP_STRGG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:SGR_6151
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 961961Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132458

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B1W4G3 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 819593B6B7225401

FASTA961102,006
        10         20         30         40         50         60 
MTPRRTPLSQ LEQGIPFEQR HIGPDAEAQA KMLAQVGYGS LDELTAAAVP DVIKSAEALN 

        70         80         90        100        110        120 
LPSARTEAEV LAELRSLADR NQVLAPMIGL GYYGTFTPPV ILRNVMENPA WYTAYTPYQP 

       130        140        150        160        170        180 
EISQGRLEAL LNFQTMVAEL TGLPTSGASL LDEGTAAAEA MALSRRVGKV KKGVFLVDAD 

       190        200        210        220        230        240 
TLPQTVAVIE TRAEPTGVEV VVADLSDGIP AEIAERGVFG VLLQYPGASG AVRAIEPVIE 

       250        260        270        280        290        300 
QAHELGAIVT VAADLLALTL LTSPGALGAD IAVGTTQRFG VPMGFGGPHA GFMAVREKFA 

       310        320        330        340        350        360 
RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM AGMYAVYHGP 

       370        380        390        400        410        420 
DGLRTIARRT HRFAAILADG LRSAGVDVVH GAFFDTLTVR VPGKAAGIVA EARERGVNLR 

       430        440        450        460        470        480 
LVDADHVSIA CDETTTRSQI SAVWAAFGAE GDIEALDAAV ADALPEGLLR SDDILTHPVF 

       490        500        510        520        530        540 
HQHRSETAML RYLRKLADRD YALDRGMIPL GSCTMKLNAT AEMESITWPE FGALHPFAPA 

       550        560        570        580        590        600 
DQAQGFLTLI RELEERLAEV TGYDAVSIQP NAGSQGEFAG LLAVRAYHRA NGDDQRTVCL 

       610        620        630        640        650        660 
IPSSAHGTNA ASAVMAGMKV VVVKTADDGE VDIADLRAKI EQHRDELAVL MITYPSTHGV 

       670        680        690        700        710        720 
FEEHVAEICG EVHDAGGQVY VDGANLNALV GLAKPGKFGG DVSHLNLHKT FCIPHGGGGP 

       730        740        750        760        770        780 
GVGPVGVRAH LAPYLPNHPL QPAAGPETGV GPISAAPWGS AGILPISWAY VRLMGGEGLK 

       790        800        810        820        830        840 
RATQVAVLAA NYIAKRLEPH FPILYNGPAG LVAHECIVDL RPISKATGVS IDDVAKRLID 

       850        860        870        880        890        900 
YGFHSPTMSF PVAGTLMIEP TESEDLAELD RFCDTMIAIR AEIEKVASGE WSADDNPLSN 

       910        920        930        940        950        960 
APHTAAALGG DWEHGYSREE AVFPAGVSAA DKYWPPVRRI DGAFGDRNLV CSCPPLDAYD 


D 

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References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009493 Genomic DNA. Translation: BAG22980.1.
RefSeqYP_001827663.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1W4G3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING455632.SGR_6151.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG22980; BAG22980; SGR_6151.
GeneID6209942.
KEGGsgr:SGR_6151.
PATRIC23759159. VBIStrGri32265_6308.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSGRI455632:GD3A-6237-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_STRGG
AccessionPrimary (citable) accession number: B1W4G3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families