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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-6237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SGR_6151
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_1000132458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_6151.

Structurei

3D structure databases

ProteinModelPortaliB1W4G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B1W4G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPRRTPLSQ LEQGIPFEQR HIGPDAEAQA KMLAQVGYGS LDELTAAAVP
60 70 80 90 100
DVIKSAEALN LPSARTEAEV LAELRSLADR NQVLAPMIGL GYYGTFTPPV
110 120 130 140 150
ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTMVAEL TGLPTSGASL
160 170 180 190 200
LDEGTAAAEA MALSRRVGKV KKGVFLVDAD TLPQTVAVIE TRAEPTGVEV
210 220 230 240 250
VVADLSDGIP AEIAERGVFG VLLQYPGASG AVRAIEPVIE QAHELGAIVT
260 270 280 290 300
VAADLLALTL LTSPGALGAD IAVGTTQRFG VPMGFGGPHA GFMAVREKFA
310 320 330 340 350
RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM
360 370 380 390 400
AGMYAVYHGP DGLRTIARRT HRFAAILADG LRSAGVDVVH GAFFDTLTVR
410 420 430 440 450
VPGKAAGIVA EARERGVNLR LVDADHVSIA CDETTTRSQI SAVWAAFGAE
460 470 480 490 500
GDIEALDAAV ADALPEGLLR SDDILTHPVF HQHRSETAML RYLRKLADRD
510 520 530 540 550
YALDRGMIPL GSCTMKLNAT AEMESITWPE FGALHPFAPA DQAQGFLTLI
560 570 580 590 600
RELEERLAEV TGYDAVSIQP NAGSQGEFAG LLAVRAYHRA NGDDQRTVCL
610 620 630 640 650
IPSSAHGTNA ASAVMAGMKV VVVKTADDGE VDIADLRAKI EQHRDELAVL
660 670 680 690 700
MITYPSTHGV FEEHVAEICG EVHDAGGQVY VDGANLNALV GLAKPGKFGG
710 720 730 740 750
DVSHLNLHKT FCIPHGGGGP GVGPVGVRAH LAPYLPNHPL QPAAGPETGV
760 770 780 790 800
GPISAAPWGS AGILPISWAY VRLMGGEGLK RATQVAVLAA NYIAKRLEPH
810 820 830 840 850
FPILYNGPAG LVAHECIVDL RPISKATGVS IDDVAKRLID YGFHSPTMSF
860 870 880 890 900
PVAGTLMIEP TESEDLAELD RFCDTMIAIR AEIEKVASGE WSADDNPLSN
910 920 930 940 950
APHTAAALGG DWEHGYSREE AVFPAGVSAA DKYWPPVRRI DGAFGDRNLV
960
CSCPPLDAYD D
Length:961
Mass (Da):102,006
Last modified:May 20, 2008 - v1
Checksum:i819593B6B7225401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG22980.1.
RefSeqiYP_001827663.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG22980; BAG22980; SGR_6151.
GeneIDi6209942.
KEGGisgr:SGR_6151.
PATRICi23759159. VBIStrGri32265_6308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG22980.1.
RefSeqiYP_001827663.1. NC_010572.1.

3D structure databases

ProteinModelPortaliB1W4G3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_6151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG22980; BAG22980; SGR_6151.
GeneIDi6209942.
KEGGisgr:SGR_6151.
PATRICi23759159. VBIStrGri32265_6308.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-6237-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350.

Entry informationi

Entry nameiGCSP_STRGG
AccessioniPrimary (citable) accession number: B1W4G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.