Skip Header

Contribute Send feedback
Read comments (?) or add your own

B1W3R8 (B1W3R8_STRGG) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP MF_00344
EC=6.3.5.2 HAMAP MF_00344
Alternative name(s):
GMP synthetase HAMAP MF_00344
Glutamine amidotransferase HAMAP MF_00344
Gene names
Name:guaA HAMAP MF_00344
Ordered Locus Names:SGR_2745
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00344

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00344

Subunit structure

Homodimer By similarity. HAMAP MF_00344

Sequence similarities

Contains 1 GMP-binding domain. HAMAP MF_00344

Contains 1 glutamine amidotransferase type-1 domain. HAMAP MF_00344

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain15 – 206192Glutamine amidotransferase type-1 By similarity HAMAP MF_00344
Domain238 – 403166GMP-binding By similarity HAMAP MF_00344
Nucleotide binding234 – 2407ATP By similarity HAMAP MF_00344

Sites

Active site921Nucleophile By similarity HAMAP MF_00344
Active site1801 By similarity HAMAP MF_00344
Active site1821 By similarity HAMAP MF_00344

Sequences

Sequence LengthMass (Da)Tools
B1W3R8 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 23BBBF00D66457A0

FASTA52856,986
        10         20         30         40         50         60 
MPAAPPAAPD ATADVVLVVD FGAQYAQLIA RRVREARVYS EIVPSTMPVA EMLAKNPRAI 

        70         80         90        100        110        120 
ILSGGPSSVY AEGAPSLDRA IFEAGVPVFG MCYGFQLMAT ALGGTVDDNG AREYGRTPLH 

       130        140        150        160        170        180 
VTKAGSTLFE GTPTEQPVWM SHGDACSAAP EGFAVTASTD VVPVAAFEND EKKLYGVQYH 

       190        200        210        220        230        240 
PEVMHSTHGQ QVLEHFLYRG AGIEPNWTTT NVVEEQIALI REQVGDKRAI CGLSGGVDSA 

       250        260        270        280        290        300 
VAAALVQKAI GSQLTCVYVD HGLMRKGETE QVEKDFVAAT GAKLKVVDAE KRFLDALAGV 

       310        320        330        340        350        360 
SDPEQKRKII GREFIRVFEQ AQLEILQEEG PEVAFLVQGT LYPDVVESGG GTGTANIKSH 

       370        380        390        400        410        420 
HNVGGLPDDI EFELVEPLRQ LFKDEVRMVG QELGLPDEIV QRQPFPGPGL GIRIVGEVTK 

       430        440        450        460        470        480 
ERLDLLRDAD AIAREELTAA GLDRDIWQCP VVLLADVRSV GVQGDGRTYG HPIVLRPVSS 

       490        500        510        520 
EDAMTADWSR LPYETLAKIS TRITNEVAEV NRVVLDVTSK PPGTIEWE

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009493 Genomic DNA. Translation: BAG19574.1.
RefSeqYP_001824257.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1W3R8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1W3R8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6209215.
GenomeReviewsGene locus SGR_2745 in contig AP009493_GR.
KEGGsgr:SGR_2745.
PATRIC23752013. VBIStrGri32265_2803.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG391775.
OMADGRTYEY.
ProtClustDBPRK00074.

Family and domain databases

HAMAPMF_00344. GMP_synthase.
[Tree]
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1W3R8_STRGG
AccessionPrimary (citable) accession number: B1W3R8
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info