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Protein

Malate dehydrogenase

Gene

mdh

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei113NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:SGR_2711
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916311 – 329Malate dehydrogenaseAdd BLAST329

Proteomic databases

PRIDEiB1W3N4

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_2711

Structurei

3D structure databases

ProteinModelPortaliB1W3N4
SMRiB1W3N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

B1W3N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTPVNVTV TGAAGQIGYA LLFRIASGHL LGPDVPVNLR LLEIPQGLKA
60 70 80 90 100
AEGTAMELDD CAFPLLRGIE ITDDPNVGFA GANVALLVGA RPRTKGMERG
110 120 130 140 150
DLLAANGGIF KPQGKAINDH AADDIKVLVV GNPANTNALI AQAAAPDVPA
160 170 180 190 200
ERFTAMTRLD HNRAISQLAA KTGAAVSDIK KLTIWGNHSA TQYPDIFHAE
210 220 230 240 250
IAGKNAAETV NDEVWLADTF IPTVAKRGAA IIEARGASSA ASAANAAIDH
260 270 280 290 300
VHTWVNGTAE GDWTSMGIPS DGSYGVPEGI ISSFPVTTKD GKYEIVQGLD
310 320
INEFSRTRID ASVKELTEER DAVRELGLI
Length:329
Mass (Da):34,562
Last modified:May 20, 2008 - v1
Checksum:i209432FDA3A637F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG19540.1
RefSeqiWP_003966840.1, NC_010572.1

Genome annotation databases

EnsemblBacteriaiBAG19540; BAG19540; SGR_2711
GeneIDi6215295
KEGGisgr:SGR_2711

Similar proteinsi

Entry informationi

Entry nameiMDH_STRGG
AccessioniPrimary (citable) accession number: B1W3N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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