B1W2V6 (B1W2V6_STRGG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540
Ordered Locus Names:	SGR_2641

Organism

Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]

Taxonomic identifier

455632 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 SAAS SAAS006330
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540 SAAS SAAS006330
Ligand	Metal-binding HAMAP MF_00540 SAAS SAAS006330 Zinc HAMAP MF_00540 SAAS SAAS006330
Molecular function	Hydrolase HAMAP MF_00540 SAAS SAAS006330
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	215	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	23	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	25	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	212	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	304	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	25	1	Substrate By similarity HAMAP MF_00540
	Binding site	27	1	Substrate By similarity HAMAP MF_00540
	Binding site	185	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	236	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	B1W2V6 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 7644DD8F588734B9	FASTA	384	42,297
	10 20 30 40 50 60 MTSQTPNVPD SDQIRRAPKV LLHDHLDGGL RPGTIVELAR AQGYDSLPET EADKLGIWFR 70 80 90 100 110 120 EAADSGSLER YLETFAHTCA VMQTRDALFR VAAECAEDLA EDGVVYAEIR YAPEQHLEGG 130 140 150 160 170 180 LTLEEVVEAV NEGFREGERV ARANGHRIRV GALLTAMRHA ARALEIAELA NSYRDQGVVG 190 200 210 220 230 240 FDIAGAEAGF PPTRHLDAFE YLKRENNHFT IHAGEAFGLP SIWQALQWCG ADRLGHGVRI 250 260 270 280 290 300 IDDIEVAEDG SVSLGRLASY VRDKRVPLEM CPTSNLQTGA AASYAEHPIG LLRKLHFRIT 310 320 330 340 350 360 VNTDNRLMSG TSMTGEFERL TEAFGYTLDD MQWFTVNAMK SAFIPFDERL AMINDVVKPG 370 380 YAALKSEWLF RQTAVTSGSA VSAG

References

[1]

"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350." Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S. J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009493 Genomic DNA. Translation: BAG19470.1.
RefSeq	YP_001824153.1. NC_010572.1.
3D structure databases
ProteinModelPortal	B1W2V6.
ModBase	Search...
Protein-protein interaction databases
STRING	B1W2V6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6209197.
GenomeReviews	Gene locus SGR_2641 in contig AP009493_GR.
KEGG	sgr:SGR_2641.
PATRIC	23751783. VBIStrGri32265_2688.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	PYYMAMN.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1W2V6_STRGG

Accession

Primary (citable) accession number: B1W2V6

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)