B1W221 (KCY_STRGG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	SGR_5739

Organism

Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]

Taxonomic identifier

455632 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Cytidylate kinase HAMAP MF_00238		PRO_1000100690
Regions
	Nucleotide binding	18 – 26	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1W221 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: A735C02FE2282E91	FASTA	231	23,689
	10 20 30 40 50 60 MSTTVETARS SVIVAIDGPS GTGKSSTSKA VAAKLGLSYL DTGAQYRAIT WWMLTNGVDV 70 80 90 100 110 120 GNPEEIATAA AKPVIVSGTD PAAPTITVDG EDASGPIRTQ EVTSKVSAVS AVPEVRTLIT 130 140 150 160 170 180 ALQRSIAAAA TGGIVVEGRD IGTTVLPDAD LKIFLTASPE ARAARRSGEV KGSDLSATRE 190 200 210 220 230 ALIKRDAADS GRKTSPLAKA DDAVEVDTTE LTLQQVIECV VTLVEGKRVA A

References

[1]

"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350." Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S. J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009493 Genomic DNA. Translation: BAG22568.1.
RefSeq	YP_001827251.1. NC_010572.1.
3D structure databases
ProteinModelPortal	B1W221.
ModBase	Search...
Protein-protein interaction databases
STRING	B1W221.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6214556.
GenomeReviews	Gene locus SGR_5739 in contig AP009493_GR.
KEGG	sgr:SGR_5739.
PATRIC	23758277. VBIStrGri32265_5878.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG354377.
OMA	DIGTVIC.
ProtClustDB	PRK00023.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_STRGG

Accession

Primary (citable) accession number: B1W221

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program