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B1W0Z7 (G6PI_STRGG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:SGR_5578
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000125762

Sites

Active site3901 By similarity
Active site5141 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1W0Z7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 2E34413F7DE110F0

FASTA55260,820
        10         20         30         40         50         60 
MNAASRTKLN QTPEWTALAK HREELGAPRL RELFARQPDR GTAYTLRVGD LHLDYSKHLV 

        70         80         90        100        110        120 
TDETLRLLRE LAAATGVAEL REAMFRGEKI NTTEDRAVLH TALRAPRDAV VEVDGENVVP 

       130        140        150        160        170        180 
AVHAVLDKMA GFAEKVRSGQ WTGHTGKPVK NIVNIGIGGS DLGPAMAYEV LRSFTDRDLT 

       190        200        210        220        230        240 
LRFVSNVDGA DLHEAVRDLD PAETLFVIAS KTFTTIETIT NATSARDWLL TELRTGQDAV 

       250        260        270        280        290        300 
AKHFVALSTN AEKVEEFGID TANMFEFWDW VGGRYSYDSA IGLSLMVAIG PDRFREMLEG 

       310        320        330        340        350        360 
FHLVDEHFRT APPEENAPLL LGLLGVWYGN FFDAQSHAVL PYSHYLSKFT AYLQQLDMES 

       370        380        390        400        410        420 
NGKSVDRDGN PVDWQTGPVV WGTPGTNGQH AYYQLIHQGT KLIPADFIGF AAPVHDLLPG 

       430        440        450        460        470        480 
LIAQHDLLMA NFFAQTQALA FGKTPEEVRA EGVPEELVPH KTFRGNHPTT TILADKLTPS 

       490        500        510        520        530        540 
VLGQLIALYE HKVFVQGAIW NIDSFDQWGV ELGKVLAKKI EPLLTGDGGA DAGELDSSTA 

       550 
ALVDAYRTLR GR

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009493 Genomic DNA. Translation: BAG22407.1.
RefSeqYP_001827090.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1W0Z7.
SMRB1W0Z7. Positions 3-550.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1W0Z7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6214275.
GenomeReviewsGene locus SGR_5578 in contig AP009493_GR.
KEGGsgr:SGR_5578.
PATRIC23757941. VBIStrGri32265_5713.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG352954.
OMAPAMAYEV.
ProtClustDBPRK00179.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. False negative.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_STRGG
AccessionPrimary (citable) accession number: B1W0Z7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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