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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Phosphoribosyl isomerase A (priA)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-5540-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Ordered Locus Names:SGR_5469
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Indole-3-glycerol phosphate synthasePRO_1000095894Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_5469.

Structurei

3D structure databases

ProteinModelPortaliB1W0N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
HOGENOMiHOG000230462.
KOiK01609.
OMAiMIDPYQI.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A. 1 hit.
MF_00134_B. IGPS_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1W0N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLDEIIDG VRADLAERQA RVSLDELKER AARAPQAKDG VAALRGEGVT
60 70 80 90 100
VICEVKRSSP SKGALAAIAD PAALAADYEA GGASVISVLT EERRFGGSLA
110 120 130 140 150
DLEAVRAKVD IPILRKDFIV TSYQLWEARA YGADLALLIV AALDQEALVS
160 170 180 190 200
LIERAESIGL TPLVEAHDEE EAERAVDAGA KIIGVNARNL KDLKVDRSTF
210 220 230 240 250
ERVAPEIPDH IVKVAESGVR GPHDLIAYAN AGADAVLVGE SLVTGRDPRA
260
AVADLVAAGA HPALRHGRG
Length:269
Mass (Da):28,269
Last modified:May 20, 2008 - v1
Checksum:i1E5749C0619794E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG22298.1.
RefSeqiWP_003969760.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG22298; BAG22298; SGR_5469.
GeneIDi6212912.
KEGGisgr:SGR_5469.
PATRICi23757715. VBIStrGri32265_5601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG22298.1.
RefSeqiWP_003969760.1. NC_010572.1.

3D structure databases

ProteinModelPortaliB1W0N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_5469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG22298; BAG22298; SGR_5469.
GeneIDi6212912.
KEGGisgr:SGR_5469.
PATRICi23757715. VBIStrGri32265_5601.

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
HOGENOMiHOG000230462.
KOiK01609.
OMAiMIDPYQI.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciSGRI455632:GD3A-5540-MONOMER.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A. 1 hit.
MF_00134_B. IGPS_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC_STRGG
AccessioniPrimary (citable) accession number: B1W0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.