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B1W0M4

- HIS4_STRGG

UniProt

B1W0M4 - HIS4_STRGG

Protein

Phosphoribosyl isomerase A

Gene

priA

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Involved in both the histidine and tryptophan biosynthetic pathways.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111Proton acceptorUniRule annotation
    Active sitei130 – 1301Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP
    2. tryptophan biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Histidine biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciSGRI455632:GD3A-5526-MONOMER.
    UniPathwayiUPA00031; UER00009.
    UPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl isomerase AUniRule annotation
    Alternative name(s):
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
    Short name:
    PRAIUniRule annotation
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:priAUniRule annotation
    Synonyms:hisAUniRule annotation
    Ordered Locus Names:SGR_5455
    OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
    Taxonomic identifieri455632 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001685: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Phosphoribosyl isomerase APRO_1000190562Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi455632.SGR_5455.

    Structurei

    3D structure databases

    ProteinModelPortaliB1W0M4.
    SMRiB1W0M4. Positions 1-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    OMAiTNIDSEG.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1W0M4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKLELLPAV DVRDGQAVRL VHGESGSETS YGSPLEAALA WQSAGAEWLH    50
    LVDLDAAFGT GDNRALIAEV AGAMDIKVEL SGGIRDDASL AAALATGCRR 100
    VNLGTAALET PEWVAKVIAE HGDKIAVGLD VRGTTLRGRG WTRDGGDLYE 150
    TLARLDSEGC ARYVVTDIAK DGTLEGPNLG LLRDVCAATD RPVVASGGVS 200
    SLDDLRAISL LVPEGVEGAI VGKALYAKAF TLEEALKAVA A 241
    Length:241
    Mass (Da):24,973
    Last modified:May 20, 2008 - v1
    Checksum:i1CE4E4ECC9A0F045
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG22284.1.
    RefSeqiWP_003969744.1. NC_010572.1.
    YP_001826967.1. NC_010572.1.

    Genome annotation databases

    EnsemblBacteriaiBAG22284; BAG22284; SGR_5455.
    GeneIDi6214518.
    KEGGisgr:SGR_5455.
    PATRICi23757685. VBIStrGri32265_5586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG22284.1 .
    RefSeqi WP_003969744.1. NC_010572.1.
    YP_001826967.1. NC_010572.1.

    3D structure databases

    ProteinModelPortali B1W0M4.
    SMRi B1W0M4. Positions 1-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455632.SGR_5455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG22284 ; BAG22284 ; SGR_5455 .
    GeneIDi 6214518.
    KEGGi sgr:SGR_5455.
    PATRICi 23757685. VBIStrGri32265_5586.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    OMAi TNIDSEG.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    UPA00035 ; UER00042 .
    BioCyci SGRI455632:GD3A-5526-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
      Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
      J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 4626 / NBRC 13350.

    Entry informationi

    Entry nameiHIS4_STRGG
    AccessioniPrimary (citable) accession number: B1W0M4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3