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B1W0I8 (B1W0I8_STRGG) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:SGR_5419
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding124 – 1307ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
B1W0I8 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: FC9AE01B2951530C

FASTA47650,011
        10         20         30         40         50         60 
MSSTVDWQGK HVTVAGLGVS GVPAARALHE RGALVTVVND GDDERARAQA AELEALGVTV 

        70         80         90        100        110        120 
RLGDGATLPP STELVVTAPG WQPDKPLFLA AAEAGIPVWG DVELAWRLRG DDGRKPAPWL 

       130        140        150        160        170        180 
AVTGTNGKTT TVRMLASILR AAGLRTEAVG NIGVSLLDAV VGETEYDVLA VELSSYQLHW 

       190        200        210        220        230        240 
APSLRAHSAA VLNLAPDHLD WHGSMEAYAA DKGRVYEGNT VACVYNVADP ATEDLVREAD 

       250        260        270        280        290        300 
VVEGCRAIGF TLGAPGPSQL GVVDGILVDR AFVADRHKQA QELAEVSDVD PPAPHNIANA 

       310        320        330        340        350        360 
LAAAALARAF GVQPAAVRDG LRAFRPDAHR IEHVADLDEV RYVDDSKATN THATEASLAA 

       370        380        390        400        410        420 
YDSIVWIAGG LAKGATFDEL VIGAAKRLRG VVLIGADRAL IREALTRHAP EVPVVDLDRT 

       430        440        450        460        470 
DTGAMSEAVA RAAELARPGD TVLLAPACAS MDMFTNYNKR GEAFADAVRA RADESA

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009493 Genomic DNA. Translation: BAG22248.1.
RefSeqYP_001826931.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1W0I8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1W0I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6210188.
GenomeReviewsGene locus SGR_5419 in contig AP009493_GR.
KEGGsgr:SGR_5419.
PATRIC23757613. VBIStrGri32265_5550.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBPRK01438.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
PROSITEPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1W0I8_STRGG
AccessionPrimary (citable) accession number: B1W0I8
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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