B1VZV3 (B1VZV3_STRGG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

SGR_5399

Organism

Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]

Taxonomic identifier

455632 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1VZV3 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 81FD13DCDBFBF8AE	FASTA	305	33,321
	10 20 30 40 50 60 MALGTASTRT DHARTVRDLL ATGKTSYSFE FWAPKTEKGE RNLWNALRRV EAVRPSFVSV 70 80 90 100 110 120 TYGAGGSTRA GTVRATQQIA ADSTLTPVAH LTAVNHSVAE LRNMIGQYAD AGIRNILAVR 130 140 150 160 170 180 GDPPGDPMGE WVEHPQGVKY AADLVRLIKE SGDFCVGVAA FPEMHPRSSD WETDIGHFVD 190 200 210 220 230 240 KCRAGADYAI TQMFFRPEDY LRMRDRVVAA GCETPVIPEV MPLTSVKQLE KFSQLSNATV 250 260 270 280 290 300 PASLKERILA AKDDPAAVRS IGIEFATEFC AKLLSEGVPG LHFITLNNST ATLEIYEKLG LHKQS

References

[1]

"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350." Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S. J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009493 Genomic DNA. Translation: BAG22228.1.
RefSeq	YP_001826911.1. NC_010572.1.
3D structure databases
ProteinModelPortal	B1VZV3.
ModBase	Search...
Protein-protein interaction databases
STRING	B1VZV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6211447.
GenomeReviews	Gene locus SGR_5399 in contig AP009493_GR.
KEGG	sgr:SGR_5399.
PATRIC	23757571. VBIStrGri32265_5529.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK902283.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1VZV3_STRGG

Accession

Primary (citable) accession number: B1VZV3

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)