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B1VYZ5 (DDL_STRGG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:SGR_1921
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000091208

Regions

Domain171 – 381211ATP-grasp
Nucleotide binding207 – 26256ATP By similarity

Sites

Metal binding3351Magnesium or manganese 1 By similarity
Metal binding3481Magnesium or manganese 1 By similarity
Metal binding3481Magnesium or manganese 2 By similarity
Metal binding3501Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1VYZ5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 0B20563B9E6778F7

FASTA39142,453
        10         20         30         40         50         60 
MSSENLPQSP ERAESPQAPR RKPRVAVVFG GRSSEHGISV VTAGAVMRAI DRTTYDVLPI 

        70         80         90        100        110        120 
GITTDGRWAL TADEPERMAI TDRKVPDVDR LTESAEGSVV LSVDPGSREV VYTEPGSVPK 

       130        140        150        160        170        180 
ALGEVDVVFP VLHGPYGEDG TLQGLLELSG VPYVGAGVLA SAVGQDKEYM KRVFLSFGLP 

       190        200        210        220        230        240 
VGPYEVVRPR EWDNDPAAAR ERIVDFAGEH GWPLFIKPAR GGSSMGITKV DSVEGLDAAI 

       250        260        270        280        290        300 
EEARRHDPKF LVESLLRGRE IECGVLEFED GPRASVPAEI PPVTSHDFYD FEAKYIDSAA 

       310        320        330        340        350        360 
GLVPAPLTEE QTAEVRRLAV AAFDAVSCEG LVRADFFLTE DGTFVINEIN TLPGFTPISM 

       370        380        390 
YPRMWQESGV DYPELVDRLI QAALSRSTGL R 

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009493 Genomic DNA. Translation: BAG18750.1.
RefSeqYP_001823433.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1VYZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING455632.SGR_1921.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG18750; BAG18750; SGR_1921.
GeneID6209724.
KEGGsgr:SGR_1921.
PATRIC23750291. VBIStrGri32265_1950.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycSGRI455632:GD3A-1929-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_STRGG
AccessionPrimary (citable) accession number: B1VYZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways