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B1VYF1 (B1VYF1_STRGG) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH EMBL BAG21936.1
Synonyms:fabH2 HAMAP MF_01815
Ordered Locus Names:SGR_5107
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region269 – 2735ACP-binding By similarity HAMAP MF_01815

Sites

Active site1221 By similarity HAMAP MF_01815
Active site2681 By similarity HAMAP MF_01815
Active site2991 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B1VYF1 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: B1DF496FA29EFDFE

FASTA34335,906
        10         20         30         40         50         60 
MSKIKPSKGA PYARIIGVGG YRPTRVVPNE VILETIDSSD EWIRSRSGIV TRHWASDEET 

        70         80         90        100        110        120 
VAAMSIEASG KAIADAGIDP EQIGAVVVST VSHFKQTPAV ATEIAHRIGA GKPAAFDISA 

       130        140        150        160        170        180 
GCAGFGYGLT LAKGMVVEGS AEYVLVIGVE RLSDLTDLED RATAFLFGDG AGAVIVGPSQ 

       190        200        210        220        230        240 
EPAIGPTVWG SEGDKSETIK QTVAWNDLHI GDVSKLPLDS KGEVKFPAIT QEGQAVFRWA 

       250        260        270        280        290        300 
VFEMAKVAQQ ALDAAGIAPE DLDVFIPHQA NMRIIDSMVK TLKLPEHVTV ARDVESTGNT 

       310        320        330        340 
SAASIPLAME RLLATGQAKS GDTALVIGFG AGLVYAATVV TLP

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009493 Genomic DNA. Translation: BAG21936.1.
RefSeqYP_001826619.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1VYF1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VYF1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6215750.
GenomeReviewsGene locus SGR_5107 in contig AP009493_GR.
KEGGsgr:SGR_5107.
PATRIC23756967. VBIStrGri32265_5228.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAVPNEVIL.
ProtClustDBPRK12879.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 3 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1VYF1_STRGG
AccessionPrimary (citable) accession number: B1VYF1
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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