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B1VXZ6

- PNP_STRGG

UniProt

B1VXZ6 - PNP_STRGG

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, SGR_1783
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi514 – 5141Magnesium By similarity
Metal bindingi520 – 5201Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-1791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:SGR_1783
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_1000192499Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_1783.

Structurei

3D structure databases

ProteinModelPortaliB1VXZ6.
SMRiB1VXZ6. Positions 3-717.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini580 – 63960KHAdd
BLAST
Domaini651 – 72373S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VXZ6-1 [UniParc]FASTAAdd to Basket

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MENETHYAEA VIDNGTFGTR TIRFETGRLA KQAAGSAVAY LDDDTMVLSA    50
TTASKRPKDN LDFFPLTVDV EERQYAAGKI PGSFFRREGR PSEDAILTCR 100
LIDRPLRPSF KKGLRNEIQI VETIMALNPD HLYDVVAINA ASCSTILAGL 150
PFSGPIGATR VALIKGQWVA FPTHTELEDA VFDMVVAGRV LEDGDVAIMM 200
VEAEATEKTI QLVKDGAEAP TEEIVAAGLD AAKPFIKALC KAQSDLASKA 250
AKPVGEFPVF LDYQDDVFEA LAKAVTSELK QALTIAGKQD REAELDRVKE 300
IAAEKLLPAF EGREKEISAA YRSLTKQLVR ERVIKDKVRI DGRGVTDIRT 350
LAAEVEAIPR VHGSALFERG ETQILGVTTL NMLRMEQQLD TLSPVTRKRY 400
MHNYNFPPYS VGETGRVGSP KRREIGHGAL AERAIVPVLP TREEFPYAIR 450
QVSEALGSNG STSMGSVCAS TMSLLNAGVP LKAAVAGIAM GLISQEIDGK 500
THYVALTDIL GAEDAFGDMD FKVAGTKQFV TALQLDTKLD GIPASVLAAA 550
LKQARDARLH ILDVMNEAID VPDEMSPNAP RIITVKIPVD KIGEVIGPKG 600
KMINQIQEDT GADITIEDDG TIYIGAQAGS QAEAARATIN AIANPTMPEV 650
GERYLGTVVK TTTFGAFVSL MPGKDGLLHI SQIRKLAGGK RVENVEDVLG 700
VGAKVQVEIA EIDSRGKLSL IPVIEGEEDE KKDDTDK 737
Length:737
Mass (Da):79,534
Last modified:May 20, 2008 - v1
Checksum:i1F1EFBEA60D12F58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG18612.1.
RefSeqiYP_001823295.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG18612; BAG18612; SGR_1783.
GeneIDi6209815.
KEGGisgr:SGR_1783.
PATRICi23750011. VBIStrGri32265_1810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG18612.1 .
RefSeqi YP_001823295.1. NC_010572.1.

3D structure databases

ProteinModelPortali B1VXZ6.
SMRi B1VXZ6. Positions 3-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455632.SGR_1783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG18612 ; BAG18612 ; SGR_1783 .
GeneIDi 6209815.
KEGGi sgr:SGR_1783.
PATRICi 23750011. VBIStrGri32265_1810.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SGRI455632:GD3A-1791-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350.

Entry informationi

Entry nameiPNP_STRGG
AccessioniPrimary (citable) accession number: B1VXZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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