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B1VXN6 (HEMH_STRGG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:SGR_1673
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Ferrochelatase HAMAP MF_00323
PRO_1000116082

Sites

Metal binding1911Iron By similarity
Metal binding2861Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B1VXN6 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: DA1510A14F3FAC58

FASTA37540,312
        10         20         30         40         50         60 
MSDLRDPAPY DALLLLSFGG PEGPDDVVPF LANVTRGRGI PEERLKEVGQ HYFLFGGVSP 

        70         80         90        100        110        120 
INEQNRALLG ALRKDFADHG LDLPVYWGNR NWAPYLTDVL REMTTDGHRR IAVLATSAYA 

       130        140        150        160        170        180 
SYSGCRQYRE NLAESLAALE AEGLEVPRVD KLRHYFNHPG FVAPMVDGVL ASLADLPEDV 

       190        200        210        220        230        240 
RAGAHLAFTT HSIPTSAADA SGPVEAHGEG GAYVAEHLDV ARLIVDAVRA ETGIEYPWRL 

       250        260        270        280        290        300 
VYQSRSGAPH IPWLEPDICD HLETLGAEGV PAVVMAPIGF VSDHMEVLYD LDTEATAKAA 

       310        320        330        340        350        360 
EIGLPVRRSA TVGDDPRFAA AVRDLLLERA ATERGRAVER CALGSLGPSH DLCPVGCCPA 

       370 
RAPKPAAAGA DSPYV

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009493 Genomic DNA. Translation: BAG18502.1.
RefSeqYP_001823185.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1VXN6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VXN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6214979.
GenomeReviewsGene locus SGR_1673 in contig AP009493_GR.
KEGGsgr:SGR_1673.
PATRIC23749771. VBIStrGri32265_1694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAPAVVMAP.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
PROSITEPS00534. FERROCHELATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_STRGG
AccessionPrimary (citable) accession number: B1VXN6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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