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B1VXF6

- SYL_STRGG

UniProt

B1VXF6 - SYL_STRGG

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Protein
Leucine--tRNA ligase
Gene
leuS, SGR_4973
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei731 – 7311ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-5040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SGR_4973
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Leucine--tRNA ligaseUniRule annotation
PRO_1000091366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_4973.

Structurei

3D structure databases

ProteinModelPortaliB1VXF6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionUniRule annotation
Add
BLAST
Motifi728 – 7325"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VXF6-1 [UniParc]FASTAAdd to Basket

« Hide

MSETNSAAET AAPHRYTAAM AADIEARWQD FWDAEGTYEA PNPTGDLAGD    50
PELAARPKKF IMDMFPYPSG AGLHVGHPLG YIATDVYARH QRMTGHNVLH 100
TLGFDAFGLP AEQYAVQTGT HPRVSTEANM ENMKVQLRRL GLGHDNRRSF 150
ATIDSEYYKW TQWIFLQIFN SWYDSEADRA RPIAELVEQF ENGTRATPDG 200
REWGALSAAE RADLLSEYRL AYASDAPVNW SPGLGTVLAN EEVTADGRSE 250
RGNFPVFKAK LRQWNMRITA YADRLLNDLD GLDWPEAIKL QQRNWIGRSE 300
GARVEFPVDT AGGITVFTTR QDTLFGATYM VLAPEHDMVE RIIPAAWPEG 350
THPVWTGGHA SPAEAVTAYR KQAAAKSDVE RQAEAKDKTG VFTGAYATNP 400
VSGEKVPVFI ADYVLMGYGT GAIMAVPAHD ARDFAFARAF ELPMRCVVQP 450
SDDRGTDPAT WDDAFSSYDA KLVNSANDEI SLDGLGVVEA KARITEWLKE 500
HGVGEGTVNF RLRDWLFSRQ RYWGEPFPIV YDEDGIAHPL PESMLPLELP 550
EVEDYSPRTF DPEDATAQPE TPLSRNADWV NVTLDLGDGA GPRKYRRETN 600
TMPNWAGSCW YELRYLDPNN DRQLVDPSIE QYWMGPREGQ PTGGVDLYVG 650
GAEHAVLHLL YARFWSKVLH DLGHISSAEP FHKLYNQGMI QAFVYRDSRG 700
IAVPAAEVEE RDGAFYHAGE KVSRVLGKMG KSLKNAVTPD EICAEYGADT 750
LRLYEMAMGP LDVSRPWDTR AVVGQYRLLQ RLWRNVVDEA TGEVTVVDTE 800
PDEDTLRALH KAIDGVGQDM AGMRFNTAIA KVTELNNHLT KAGGPLSRSV 850
AERLVLLIAP LAPHIAEELW RRLGHADSVV HQDFPVADPA YVVDETVTCV 900
VQIKGKVRAR LEISPAITDE ELEALALADE AVVAALGGAG IRKVIVRAPK 950
LVNIVPA 957
Length:957
Mass (Da):106,033
Last modified:May 20, 2008 - v1
Checksum:i1FF90F2A1C800FB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG21802.1.
RefSeqiYP_001826485.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG21802; BAG21802; SGR_4973.
GeneIDi6211000.
KEGGisgr:SGR_4973.
PATRICi23756676. VBIStrGri32265_5086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009493 Genomic DNA. Translation: BAG21802.1 .
RefSeqi YP_001826485.1. NC_010572.1.

3D structure databases

ProteinModelPortali B1VXF6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 455632.SGR_4973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG21802 ; BAG21802 ; SGR_4973 .
GeneIDi 6211000.
KEGGi sgr:SGR_4973.
PATRICi 23756676. VBIStrGri32265_5086.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SGRI455632:GD3A-5040-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350.

Entry informationi

Entry nameiSYL_STRGG
AccessioniPrimary (citable) accession number: B1VXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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