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B1VXF6

- SYL_STRGG

UniProt

B1VXF6 - SYL_STRGG

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei731 – 7311ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSGRI455632:GD3A-5040-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SGR_4973
    OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
    Taxonomic identifieri455632 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001685: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Leucine--tRNA ligasePRO_1000091366Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi455632.SGR_4973.

    Structurei

    3D structure databases

    ProteinModelPortaliB1VXF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi66 – 7712"HIGH" regionAdd
    BLAST
    Motifi728 – 7325"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1VXF6-1 [UniParc]FASTAAdd to Basket

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    MSETNSAAET AAPHRYTAAM AADIEARWQD FWDAEGTYEA PNPTGDLAGD    50
    PELAARPKKF IMDMFPYPSG AGLHVGHPLG YIATDVYARH QRMTGHNVLH 100
    TLGFDAFGLP AEQYAVQTGT HPRVSTEANM ENMKVQLRRL GLGHDNRRSF 150
    ATIDSEYYKW TQWIFLQIFN SWYDSEADRA RPIAELVEQF ENGTRATPDG 200
    REWGALSAAE RADLLSEYRL AYASDAPVNW SPGLGTVLAN EEVTADGRSE 250
    RGNFPVFKAK LRQWNMRITA YADRLLNDLD GLDWPEAIKL QQRNWIGRSE 300
    GARVEFPVDT AGGITVFTTR QDTLFGATYM VLAPEHDMVE RIIPAAWPEG 350
    THPVWTGGHA SPAEAVTAYR KQAAAKSDVE RQAEAKDKTG VFTGAYATNP 400
    VSGEKVPVFI ADYVLMGYGT GAIMAVPAHD ARDFAFARAF ELPMRCVVQP 450
    SDDRGTDPAT WDDAFSSYDA KLVNSANDEI SLDGLGVVEA KARITEWLKE 500
    HGVGEGTVNF RLRDWLFSRQ RYWGEPFPIV YDEDGIAHPL PESMLPLELP 550
    EVEDYSPRTF DPEDATAQPE TPLSRNADWV NVTLDLGDGA GPRKYRRETN 600
    TMPNWAGSCW YELRYLDPNN DRQLVDPSIE QYWMGPREGQ PTGGVDLYVG 650
    GAEHAVLHLL YARFWSKVLH DLGHISSAEP FHKLYNQGMI QAFVYRDSRG 700
    IAVPAAEVEE RDGAFYHAGE KVSRVLGKMG KSLKNAVTPD EICAEYGADT 750
    LRLYEMAMGP LDVSRPWDTR AVVGQYRLLQ RLWRNVVDEA TGEVTVVDTE 800
    PDEDTLRALH KAIDGVGQDM AGMRFNTAIA KVTELNNHLT KAGGPLSRSV 850
    AERLVLLIAP LAPHIAEELW RRLGHADSVV HQDFPVADPA YVVDETVTCV 900
    VQIKGKVRAR LEISPAITDE ELEALALADE AVVAALGGAG IRKVIVRAPK 950
    LVNIVPA 957
    Length:957
    Mass (Da):106,033
    Last modified:May 20, 2008 - v1
    Checksum:i1FF90F2A1C800FB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG21802.1.
    RefSeqiYP_001826485.1. NC_010572.1.

    Genome annotation databases

    EnsemblBacteriaiBAG21802; BAG21802; SGR_4973.
    GeneIDi6211000.
    KEGGisgr:SGR_4973.
    PATRICi23756676. VBIStrGri32265_5086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG21802.1 .
    RefSeqi YP_001826485.1. NC_010572.1.

    3D structure databases

    ProteinModelPortali B1VXF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455632.SGR_4973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG21802 ; BAG21802 ; SGR_4973 .
    GeneIDi 6211000.
    KEGGi sgr:SGR_4973.
    PATRICi 23756676. VBIStrGri32265_5086.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SGRI455632:GD3A-5040-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
      Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
      J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 4626 / NBRC 13350.

    Entry informationi

    Entry nameiSYL_STRGG
    AccessioniPrimary (citable) accession number: B1VXF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3