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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:SGR_4531
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 939939Protein translocase subunit SecAPRO_1000145065Add
BLAST

Proteomic databases

PRIDEiB1VUY4.

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_4531.

Structurei

3D structure databases

ProteinModelPortaliB1VUY4.
SMRiB1VUY4. Positions 3-840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VUY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFNKLMRA GEGKILRKLH RIADQVSSIE EDFVNLSDAE LRALTDEYKE
60 70 80 90 100
RYADGESLDD LLPEAFATVR EAAKRVLGQR HYDVQMMGGA ALHLGYVAEM
110 120 130 140 150
KTGEGKTLVG TLPAYLNALS GKGVHLITVN DYLAERDSEL MGRVHKFLGL
160 170 180 190 200
SVGCIVANMT PAQRREQYGC DITYGTNNEF GFDYLRDNMA WSKDELVQRG
210 220 230 240 250
HNFAVVDEVD SILVDEARTP LIISGPADQA TKWYGDFAKL VTRLTKGEAG
260 270 280 290 300
NQLKGIEETG DYEVDEKKRT VAIHEAGVAK VEDWLGIDNL YESVNTPLVG
310 320 330 340 350
YLNNAIKAKE LFKKDKDYVV IDGEVMIVDE HTGRILAGRR YNEGMHQAIE
360 370 380 390 400
AKEGVDIKDE NQTLATITLQ NFFRLYDKLS GMTGTAMTEA AEFHQIYKLG
410 420 430 440 450
VVPIPTNRPM VRADQSDLIY RTEVAKFAAV VDDIAEKHEK GQPILVGTTS
460 470 480 490 500
VEKSEYLSQQ LSKRGVQHEV LNAKQHDREA TIVAQAGRKG AVTVATNMAG
510 520 530 540 550
RGTDIKLGGN PDDLAEAELR QRGLDPVENV EEWAAALPAA LETAEQAVKA
560 570 580 590 600
EFEEVKDLGG LYVLGTERHE SRRIDNQLRG RSGRQGDPGE SRFYLSLGDD
610 620 630 640 650
LMRLFKAQMV ERVMSMANVP DDVPIENKMV TRAIASAQSQ VEQQNFETRK
660 670 680 690 700
NVLKYDEVLN RQREVIYGER RRVLEGEDLQ EQIRHFMDDT IDDYIRQETA
710 720 730 740 750
EGFAEEWDLD RLWGAFKQLY PVKVTVDELE EAAGDLAGVT AEFIAESVKN
760 770 780 790 800
DIHEQYEERE NTLGSDIMRE LERRVVLSVL DRKWREHLYE MDYLQEGIGL
810 820 830 840 850
RAMAQKDPLV EYQREGFDMF NAMMEGIKEE SVGYLFNLEV QVEQQVEEVP
860 870 880 890 900
VQDGAERPSL EKEGATAAPQ IRAKGLEAPQ RPDRLHFSAP TVDGEGGVVE
910 920 930
GDFANDEATG DTRSGSADGM TRAERRKAQK GGGGRRRKK
Length:939
Mass (Da):105,233
Last modified:May 20, 2008 - v1
Checksum:iB227CDDA7B34C669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21360.1.
RefSeqiWP_003968757.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG21360; BAG21360; SGR_4531.
GeneIDi6212174.
KEGGisgr:SGR_4531.
PATRICi23755730. VBIStrGri32265_4624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21360.1.
RefSeqiWP_003968757.1. NC_010572.1.

3D structure databases

ProteinModelPortaliB1VUY4.
SMRiB1VUY4. Positions 3-840.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_4531.

Proteomic databases

PRIDEiB1VUY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG21360; BAG21360; SGR_4531.
GeneIDi6212174.
KEGGisgr:SGR_4531.
PATRICi23755730. VBIStrGri32265_4624.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4586-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350.

Entry informationi

Entry nameiSECA_STRGG
AccessioniPrimary (citable) accession number: B1VUY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: December 9, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.