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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:SGR_4531
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001450651 – 939Protein translocase subunit SecAAdd BLAST939

Proteomic databases

PRIDEiB1VUY4

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_4531

Structurei

3D structure databases

ProteinModelPortaliB1VUY4
SMRiB1VUY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

B1VUY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFNKLMRA GEGKILRKLH RIADQVSSIE EDFVNLSDAE LRALTDEYKE
60 70 80 90 100
RYADGESLDD LLPEAFATVR EAAKRVLGQR HYDVQMMGGA ALHLGYVAEM
110 120 130 140 150
KTGEGKTLVG TLPAYLNALS GKGVHLITVN DYLAERDSEL MGRVHKFLGL
160 170 180 190 200
SVGCIVANMT PAQRREQYGC DITYGTNNEF GFDYLRDNMA WSKDELVQRG
210 220 230 240 250
HNFAVVDEVD SILVDEARTP LIISGPADQA TKWYGDFAKL VTRLTKGEAG
260 270 280 290 300
NQLKGIEETG DYEVDEKKRT VAIHEAGVAK VEDWLGIDNL YESVNTPLVG
310 320 330 340 350
YLNNAIKAKE LFKKDKDYVV IDGEVMIVDE HTGRILAGRR YNEGMHQAIE
360 370 380 390 400
AKEGVDIKDE NQTLATITLQ NFFRLYDKLS GMTGTAMTEA AEFHQIYKLG
410 420 430 440 450
VVPIPTNRPM VRADQSDLIY RTEVAKFAAV VDDIAEKHEK GQPILVGTTS
460 470 480 490 500
VEKSEYLSQQ LSKRGVQHEV LNAKQHDREA TIVAQAGRKG AVTVATNMAG
510 520 530 540 550
RGTDIKLGGN PDDLAEAELR QRGLDPVENV EEWAAALPAA LETAEQAVKA
560 570 580 590 600
EFEEVKDLGG LYVLGTERHE SRRIDNQLRG RSGRQGDPGE SRFYLSLGDD
610 620 630 640 650
LMRLFKAQMV ERVMSMANVP DDVPIENKMV TRAIASAQSQ VEQQNFETRK
660 670 680 690 700
NVLKYDEVLN RQREVIYGER RRVLEGEDLQ EQIRHFMDDT IDDYIRQETA
710 720 730 740 750
EGFAEEWDLD RLWGAFKQLY PVKVTVDELE EAAGDLAGVT AEFIAESVKN
760 770 780 790 800
DIHEQYEERE NTLGSDIMRE LERRVVLSVL DRKWREHLYE MDYLQEGIGL
810 820 830 840 850
RAMAQKDPLV EYQREGFDMF NAMMEGIKEE SVGYLFNLEV QVEQQVEEVP
860 870 880 890 900
VQDGAERPSL EKEGATAAPQ IRAKGLEAPQ RPDRLHFSAP TVDGEGGVVE
910 920 930
GDFANDEATG DTRSGSADGM TRAERRKAQK GGGGRRRKK
Length:939
Mass (Da):105,233
Last modified:May 20, 2008 - v1
Checksum:iB227CDDA7B34C669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG21360.1
RefSeqiWP_003968757.1, NC_010572.1

Genome annotation databases

EnsemblBacteriaiBAG21360; BAG21360; SGR_4531
GeneIDi6212174
KEGGisgr:SGR_4531

Similar proteinsi

Entry informationi

Entry nameiSECA_STRGG
AccessioniPrimary (citable) accession number: B1VUY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health