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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Binding sitei208SubstrateUniRule annotation1
Binding sitei238SubstrateUniRule annotation1
Binding sitei242SubstrateUniRule annotation1
Binding sitei243NADUniRule annotation1
Binding sitei295NADUniRule annotation1
Binding sitei330NADUniRule annotation1
Binding sitei399NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 211NADUniRule annotation3
Nucleotide bindingi272 – 277NADUniRule annotation6
Nucleotide bindingi351 – 353NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:SGR_4513
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001293021 – 485AdenosylhomocysteinaseAdd BLAST485

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_4513.

Structurei

3D structure databases

ProteinModelPortaliB1VUW6.
SMRiB1VUW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B1VUW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTATNRQDF KVADLSLAPF GRKEITLAEH EMPGLMSIRK EFAAAQPLAG
60 70 80 90 100
ARITGSLHMT VQTAVLIETL VALGAEVRWA SCNIFSTQDH AAAAIAVGPN
110 120 130 140 150
GTPEAPAGVP VFAWKGETLE EYWWCTEQAL TWPNTPTGGP NMILDDGGDA
160 170 180 190 200
TLLVHKGVEF EKAGAAPDPS TADSEEYAHI LTLLNRTLGE APQKWTQLAS
210 220 230 240 250
EIRGVTEETT TGVHRLYEMH RDGSLLFPAI NVNDAVTKSK FDNKYGCRHS
260 270 280 290 300
LIDGINRATD VLIGGKTAVV FGYGDVGKGC AESLRGQGAR VIITEIDPIC
310 320 330 340 350
ALQAAMDGYQ VATLDDVVEQ ADIFVTTTGN KDIIMAKDMA RMKHQAIVGN
360 370 380 390 400
IGHFDNEIDM AGLAKIDGIV KDEVKPQVHT WTFPDGKVLI VLSEGRLLNL
410 420 430 440 450
GNATGHPSFV MSNSFADQTL AQIELFTKPE DYPTDVYVLP KHLDEKVARL
460 470 480
HLDALGVKLT TLRPEQAAYI GVEVEGPYKP DHYRY
Length:485
Mass (Da):52,634
Last modified:May 20, 2008 - v1
Checksum:iB9D426AD4EFC62C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21342.1.
RefSeqiWP_003968738.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG21342; BAG21342; SGR_4513.
GeneIDi6214199.
KEGGisgr:SGR_4513.

Similar proteinsi

Entry informationi

Entry nameiSAHH_STRGG
AccessioniPrimary (citable) accession number: B1VUW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families