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Protein

2-phospho-L-lactate transferase

Gene

cofD

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP.UniRule annotation

Catalytic activityi

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = guanosine 5'-phosphate + coenzyme F420-0.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4553-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate transferaseUniRule annotation (EC:2.7.8.28UniRule annotation)
Alternative name(s):
LPPG:FO 2-phospho-L-lactate transferaseUniRule annotation
Gene namesi
Name:cofDUniRule annotation
Ordered Locus Names:SGR_4501
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3183182-phospho-L-lactate transferasePRO_1000139982Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_4501.

Structurei

3D structure databases

ProteinModelPortaliB1VUV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EIH. Bacteria.
COG0391. LUCA.
HOGENOMiHOG000230060.
KOiK11212.
OMAiHFQEYWV.

Family and domain databases

HAMAPiMF_01257. CofD. 1 hit.
InterProiIPR002882. CofD/UPF0052.
IPR010115. P-lactate_Trfase.
[Graphical view]
PfamiPF01933. UPF0052. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01819. F420_cofD. 1 hit.

Sequencei

Sequence statusi: Complete.

B1VUV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVVLAGGI GGARFLRGLK QAAPDADITV IGNTGDDIHL FGLKVCPDLD
60 70 80 90 100
TVMYTLGGGI NEEQGWGRTD ETFQVKEELA AYGVGPGWFG LGDRDFATHI
110 120 130 140 150
VRTQMLGAGY PLSAVTEALC ARWQPGVRLL PMSDDRVETH VAVETDGESK
160 170 180 190 200
AIHFQEYWVK LRASVEAQAI VPVGAEQAKP APGVLEAIGS ADVIVFPPSN
210 220 230 240 250
PVVSIGTILA VPGIREAIAE AGVPVVGLSP IVGDAPVRGM ADKVLAAVGV
260 270 280 290 300
ESTAAAVARH YGSGLLDGWL VDTVDAGAVE EVEAAGIRCR AVPLMMTDVD
310
ATAAMARQAL ELAEEVRA
Length:318
Mass (Da):33,169
Last modified:May 20, 2008 - v1
Checksum:i07BA5FC4830F4D69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21330.1.
RefSeqiWP_003968726.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG21330; BAG21330; SGR_4501.
GeneIDi6209896.
KEGGisgr:SGR_4501.
PATRICi23755662. VBIStrGri32265_4593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21330.1.
RefSeqiWP_003968726.1. NC_010572.1.

3D structure databases

ProteinModelPortaliB1VUV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_4501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG21330; BAG21330; SGR_4501.
GeneIDi6209896.
KEGGisgr:SGR_4501.
PATRICi23755662. VBIStrGri32265_4593.

Phylogenomic databases

eggNOGiENOG4105EIH. Bacteria.
COG0391. LUCA.
HOGENOMiHOG000230060.
KOiK11212.
OMAiHFQEYWV.

Enzyme and pathway databases

UniPathwayiUPA00071.
BioCyciSGRI455632:GD3A-4553-MONOMER.

Family and domain databases

HAMAPiMF_01257. CofD. 1 hit.
InterProiIPR002882. CofD/UPF0052.
IPR010115. P-lactate_Trfase.
[Graphical view]
PfamiPF01933. UPF0052. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01819. F420_cofD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOFD_STRGG
AccessioniPrimary (citable) accession number: B1VUV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.