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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351UniRule annotation
Active sitei567 – 5671UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:SGR_4379Imported
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)Imported
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_4379.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VUI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSADQTPAA SPALRADIRR LGDLLGETLV RQEGQELLDL VERVRALTRT
60 70 80 90 100
DGEAAAELLG DTDLETAARL VRAFSTYFHL ANVTEQVHRA HEMRDRRAAE
110 120 130 140 150
GGLLARTADR LKDADPEHLR ETVKNLNVRP VFTAHPTEAA RRSVLNKLRR
160 170 180 190 200
IAALLETPAI EADRRRLDLR LAENIDLIWQ TDELRVVRPE PADEARNAIY
210 220 230 240 250
YLDELHTGAV GDVLEDLAAE LERVGVELPA GTRPLTFGTW IGGDRDGNPN
260 270 280 290 300
VTPAVTWDVL ILQHEHGITD ALEMIDHLRG LLSNSIRYAG ATEELLTSLQ
310 320 330 340 350
ADLERLPGIS PRYKRLNAEE PYRLKATCIR QKLVNTRERL AEGTPHRPGC
360 370 380 390 400
DYLGTAELIA DLELIQTSLR AHKGGLFADG RMDRTIRTLG AFGLQLATMD
410 420 430 440 450
VREHADAHHH ALGQLFDRLG EESWRYADMP RDYRQKLLAK ELRSRRPLAP
460 470 480 490 500
TPAPLDAAGE KTLGVFHTIK QAFERFGPEV IESYIISMCQ GADDVFAAAV
510 520 530 540 550
LAREAGLVDL HAGWAKIGIV PLLETTDELK AADVILDEML ADPSYRRLVS
560 570 580 590 600
LRGDVQEVML GYSDSSKFGG ITTSQWEIHR AQRRLRDVAH RYGVRLRLFH
610 620 630 640 650
GRGGTVGRGG GPSHDAILAQ PWGTLEGEIK VTEQGEVISD KYLIPALARE
660 670 680 690 700
NLELTVAATL QASALHTAPR QSDEALARWD AAMDTVSDAA HSAYRKLVED
710 720 730 740 750
PDLPAYFLAS TPVDQLADLH LGSRPSRRPG SGVSLDGLRA IPWVFGWTQS
760 770 780 790 800
RQIVPGWYGV GSGLKALREA GLDTVLDEMH EHWHFFRNFL SNVEMTLAKT
810 820 830 840 850
DLRIARHYVD TLVPDELKHV FDAIEAEHAL TVREVLKVTG STELLGTSPV
860 870 880 890 900
LQQTFGIRDA YLDPISYLQV SLLARQRQAA ERGEEPDPLL ARALLLTVNG

VAAGLRNTG
Length:909
Mass (Da):100,668
Last modified:May 20, 2008 - v1
Checksum:iADA946B0ECF079FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21208.1.
RefSeqiYP_001825891.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG21208; BAG21208; SGR_4379.
GeneIDi6215943.
KEGGisgr:SGR_4379.
PATRICi23755402. VBIStrGri32265_4465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG21208.1.
RefSeqiYP_001825891.1. NC_010572.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_4379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG21208; BAG21208; SGR_4379.
GeneIDi6215943.
KEGGisgr:SGR_4379.
PATRICi23755402. VBIStrGri32265_4465.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4429-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350Imported.

Entry informationi

Entry nameiB1VUI2_STRGG
AccessioniPrimary (citable) accession number: B1VUI2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 4, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.