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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGRI455632:G1G2X-4232-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:SGR_4178
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000954081 – 594Arginine--tRNA ligaseAdd BLAST594

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_4178

Structurei

3D structure databases

ProteinModelPortaliB1VTB7
SMRiB1VTB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 137"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247212
KOiK01887
OMAiALCVFFD

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1VTB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPSLAST LQQQLADALT AALPDAGAAD PLLRRSDRAD FQANGILALA
60 70 80 90 100
KKLKGNPREL AAQVTAALPA GGLIKDIEVS GPGFLNVTLT DRAIVETLAA
110 120 130 140 150
RAADGEGRLG VPLKDDAGTT VIDYAQPNVA KEMHVGHLRS AVIGDAVVRI
160 170 180 190 200
LEFTGENVVR RHHIGDWGTQ FGMLIQYLIE HPGALQHEGG PGDGASDGEA
210 220 230 240 250
AMSTLNRVYK ESRALFDSDE EFKARSRDRV VALQAGDPGT LELWHRFVDE
260 270 280 290 300
SKIYFHSVFD KLDMEIRDPD IVGESGYNDM LEETCRILEE TGVAVRSEGA
310 320 330 340 350
LCVFFDDVKG PDGNRVPLIV KKTNGGYGYA ATDLSAVRNR VQDLKADTLL
360 370 380 390 400
YVVDARQSLH FRMVFETARR AGWLGDDVKA VQLAFGTVLG KDGKPFKTRE
410 420 430 440 450
GETVRLEDLL DEAVQRATAV VRDKAEKVGL SEEEIVENGR YVGIGAVKYA
460 470 480 490 500
DLSTSAVRDY KFDLDQMVAL HGDTSVYLQY AYARIRSILR KAGDAVPAAH
510 520 530 540 550
PELELAPAER ALGLHLDQFG EVLAEVGTGY EPHKLAAYLY QLASHLTTFY
560 570 580 590
DQCQVLSPDN APEVVENRLF LVELTARTLH RGMALLGIRT PERL
Length:594
Mass (Da):64,757
Last modified:May 20, 2008 - v1
Checksum:iD572DB562773B6BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG21007.1
RefSeqiWP_012380409.1, NC_010572.1

Genome annotation databases

EnsemblBacteriaiBAG21007; BAG21007; SGR_4178
GeneIDi6209259
KEGGisgr:SGR_4178
PATRICifig|455632.4.peg.4255

Similar proteinsi

Entry informationi

Entry nameiSYR_STRGG
AccessioniPrimary (citable) accession number: B1VTB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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