B1VT97 (B1VT97_STRGG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

SGR_4158

Organism

Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]

Taxonomic identifier

455632 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	203	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	255	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	240	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	213	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	224	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	281	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	320	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	B1VT97 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 5683ED62ABC4F27A	FASTA	335	36,058
	10 20 30 40 50 60 MTAYGNFPGS RPRRLRTTPA MRRMVAETRL DPANLILPAF VREGIDAPVA IAAMPGVYQH 70 80 90 100 110 120 TLDTLRKAAV EAVSAGVSGI MVFGVPEDEK KDARGTAGTD PDGILQVALR AVREEVGDDL 130 140 150 160 170 180 VIMSDLCLDE YTDHGHCGVL TADGRVDNDA TLERYAEMAQ VQADAGAHVV GPSGMMDGQV 190 200 210 220 230 240 GVVRDALDQT GHEDVSILAY AVKYSSAFYG PFREAVGSSL TGDRKTYQQD PANARESLRE 250 260 270 280 290 300 LALDLAEGAD MVMVKPAGPY LDILAKVAES VDVPVAAYQI SGEYAMIEAA AERGWIDRDK 310 320 330 AILESLTGIR RAGARMILTY WATEAAQWLG RDARR

References

[1]

"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350." Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S. J. Bacteriol. 190:4050-4060(2008) [PubMed: 18375553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009493 Genomic DNA. Translation: BAG20987.1.
RefSeq	YP_001825670.1. NC_010572.1.
3D structure databases
ProteinModelPortal	B1VT97.
ModBase	Search...
Protein-protein interaction databases
STRING	B1VT97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6209435.
GenomeReviews	Gene locus SGR_4158 in contig AP009493_GR.
KEGG	sgr:SGR_4158.
PATRIC	23754936. VBIStrGri32265_4234.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	FTSHGHD.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1VT97_STRGG

Accession

Primary (citable) accession number: B1VT97

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)