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Protein

Glutamate decarboxylase

Gene

SGR_4077

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4122-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:SGR_4077Imported
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)Imported
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_4077.

Structurei

3D structure databases

ProteinModelPortaliB1VSF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

B1VSF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHRGAHPE QDEPSEERRR LALNPFFGEA DPTAAMNTAP PRHRLPDGPL
60 70 80 90 100
PPLTAYRLVH DELMLDGNSR LNLATFVTTW MEPQAGVLMG ECRDKNMIDK
110 120 130 140 150
DEYPRTAELE RRCVAMLADL WNAPDPRAAV GCSTTGSSEA CMLAGLALKR
160 170 180 190 200
RWAKRNADRY PATARPNLVM GVNVQVCWEK FCDFWEVEAR LVPMEGERFH
210 220 230 240 250
LDPAAAAELC DENTIGVVGI LGSTFDGSYE PIAELCAALD AFQKRTGLDV
260 270 280 290 300
PVHVDGASGA MVAPFLDPDL VWDFRLPRVA SINTSGHKYG LVYPGVGWAL
310 320 330 340 350
WRTADALPEE LVFRVNYLGG DMPTFALNFS RPGAQVVAQY YTFLRLGHEG
360 370 380 390 400
YRAVQQASRD VACALARAIE ELGDFRLLTR GDELPVFAFT TNDDVHAYDV
410 420 430 440 450
FDVSRRLRER GWLVPAYTFP ANRQDLSVLR VVCRNGFSSD LAELLIEDLK
460 470
LLLPELRSQK HPLSHDRAVP TAFHH
Length:475
Mass (Da):52,996
Last modified:May 20, 2008 - v1
Checksum:i3BF11BB2565BEE35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG20906.1.
RefSeqiYP_001825589.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG20906; BAG20906; SGR_4077.
GeneIDi6211654.
KEGGisgr:SGR_4077.
PATRICi23754766. VBIStrGri32265_4152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG20906.1.
RefSeqiYP_001825589.1. NC_010572.1.

3D structure databases

ProteinModelPortaliB1VSF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_4077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG20906; BAG20906; SGR_4077.
GeneIDi6211654.
KEGGisgr:SGR_4077.
PATRICi23754766. VBIStrGri32265_4152.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-4122-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350Imported.

Entry informationi

Entry nameiB1VSF2_STRGG
AccessioniPrimary (citable) accession number: B1VSF2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.