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B1VRH6 (ACDH_STRGG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:SGR_565
OrganismStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) [Complete proteome] [HAMAP]
Taxonomic identifier455632 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces ›

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387747

Regions

Nucleotide binding25 – 284NAD By similarity

Sites

Active site1391Acyl-thioester intermediate By similarity
Binding site2791NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B1VRH6 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: F01F6611BB0D8159

FASTA30831,579
        10         20         30         40         50         60 
MSLTAGLTDA RPDTVETATV AVIGTGAIGR DLVSKIDRSP GLDCRLVAGR NPESAGLRYA 

        70         80         90        100        110        120 
ESLGCATTAA GIDAVLAASP FDVVFDATSA ASHRDHWPLL EPLGTLVIDL TPSKVGQMVA 

       130        140        150        160        170        180 
PTVTGVAAED ARNVNLISCG GQASVPVVHA LAARFPVTYL EVVSTVASDV AGRATRLNLD 

       190        200        210        220        230        240 
EYVTATGHAV TTFSGVSDVK IILNISPAVP PATFRTVIHA RVPDADAAAV RAVVDRAAEQ 

       250        260        270        280        290        300 
VRSFAPGYEV VACTAADDLV TIVLKVTACS DVLPPYAGNL DIINAAAVLV AEQYAARPGR 


VSRTGVSS

« Hide

References

[1]"Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 4626 / NBRC 13350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009493 Genomic DNA. Translation: BAG17394.1.
RefSeqYP_001822077.1. NC_010572.1.

3D structure databases

ProteinModelPortalB1VRH6.
ModBaseSearch...

Protein-protein interaction databases

STRING455632.SGR_565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG17394; BAG17394; SGR_565.
GeneID6211317.
KEGGsgr:SGR_565.
PATRIC23747473. VBIStrGri32265_0547.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMACVLFAGR.
ProtClustDBPRK08300.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PANTHERPTHR21123. PTHR21123. 1 hit.
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_STRGG
AccessionPrimary (citable) accession number: B1VRH6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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