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Protein

Acetaldehyde dehydrogenase

Gene

SGR_565

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139Acyl-thioester intermediateUniRule annotation1
Binding sitei279NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 28NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:SGR_565
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877471 – 308Acetaldehyde dehydrogenaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_565.

Structurei

3D structure databases

ProteinModelPortaliB1VRH6.
SMRiB1VRH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiVEYVEIV.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B1VRH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTAGLTDA RPDTVETATV AVIGTGAIGR DLVSKIDRSP GLDCRLVAGR
60 70 80 90 100
NPESAGLRYA ESLGCATTAA GIDAVLAASP FDVVFDATSA ASHRDHWPLL
110 120 130 140 150
EPLGTLVIDL TPSKVGQMVA PTVTGVAAED ARNVNLISCG GQASVPVVHA
160 170 180 190 200
LAARFPVTYL EVVSTVASDV AGRATRLNLD EYVTATGHAV TTFSGVSDVK
210 220 230 240 250
IILNISPAVP PATFRTVIHA RVPDADAAAV RAVVDRAAEQ VRSFAPGYEV
260 270 280 290 300
VACTAADDLV TIVLKVTACS DVLPPYAGNL DIINAAAVLV AEQYAARPGR

VSRTGVSS
Length:308
Mass (Da):31,579
Last modified:May 20, 2008 - v1
Checksum:iF01F6611BB0D8159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG17394.1.
RefSeqiWP_012377889.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG17394; BAG17394; SGR_565.
GeneIDi6211317.
KEGGisgr:SGR_565.
PATRICifig|455632.4.peg.547.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH_STRGG
AccessioniPrimary (citable) accession number: B1VRH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 20, 2008
Last modified: June 7, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families