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B1VMD2

- B1VMD2_STRGG

UniProt

B1VMD2 - B1VMD2_STRGG

Protein

Kynureninase

Gene

kynU

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei105 – 1051Pyridoxal phosphateUniRule annotation
    Binding sitei202 – 2021Pyridoxal phosphateUniRule annotation
    Binding sitei205 – 2051Pyridoxal phosphateUniRule annotation
    Binding sitei227 – 2271Pyridoxal phosphateUniRule annotation
    Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
    Binding sitei283 – 2831Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciSGRI455632:GD3A-3436-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:SGR_3413Imported
    OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)Imported
    Taxonomic identifieri455632 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001685: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei228 – 2281N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi455632.SGR_3413.

    Structurei

    3D structure databases

    ProteinModelPortaliB1VMD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1364Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiYLATWRT.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1VMD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETTTTARD LRERAAVLDA ADPLAARREL FALDDGVYLD GNSLGALPVH    50
    VPARVQDVLT RQWGQLRIRS WDESGWWTAP ERIGDRIAPL VGAAAGQIVV 100
    GDSTSVNVFK AVVAAGRLAG EGRDEILVDA TTFPTDGYIA SAAARLTGHR 150
    IVPVAPADVP AALGPRTAAV LLNHVDYRSG RLHDLPGLTA AVHAAGAVVV 200
    WDLCHSAGAL PVGLDEHRVD LAVGCTYKYL NGGPGSPAYL YVAERHQAAF 250
    DSPLPGWNSH ADPFGMTSGY APADGSVRGR VGTPDIVSML TLEAALDVWD 300
    GVPVDAVRAK SLALTDFFLE CVEAYVPAGR VTSVTPAAHA ERGSQVALRC 350
    AEAEPVMRRL IERGVVGDLR RPDVLRFGFT PLYVGFADAE RAARILAEVL 400
    AEVSAGDTVG 410
    Length:410
    Mass (Da):43,258
    Last modified:May 20, 2008 - v1
    Checksum:i795BDBD4DE73799C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG20242.1.
    RefSeqiWP_012379876.1. NC_010572.1.
    YP_001824925.1. NC_010572.1.

    Genome annotation databases

    EnsemblBacteriaiBAG20242; BAG20242; SGR_3413.
    GeneIDi6214162.
    KEGGisgr:SGR_3413.
    PATRICi23753396. VBIStrGri32265_3487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009493 Genomic DNA. Translation: BAG20242.1 .
    RefSeqi WP_012379876.1. NC_010572.1.
    YP_001824925.1. NC_010572.1.

    3D structure databases

    ProteinModelPortali B1VMD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455632.SGR_3413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG20242 ; BAG20242 ; SGR_3413 .
    GeneIDi 6214162.
    KEGGi sgr:SGR_3413.
    PATRICi 23753396. VBIStrGri32265_3487.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi YLATWRT.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci SGRI455632:GD3A-3436-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
      Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
      J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 4626 / NBRC 13350Imported.

    Entry informationi

    Entry nameiB1VMD2_STRGG
    AccessioniPrimary (citable) accession number: B1VMD2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3