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B1VMD2

- B1VMD2_STRGG

UniProt

B1VMD2 - B1VMD2_STRGG

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Protein

Kynureninase

Gene

kynU

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei105 – 1051Pyridoxal phosphateUniRule annotation
Binding sitei202 – 2021Pyridoxal phosphateUniRule annotation
Binding sitei205 – 2051Pyridoxal phosphateUniRule annotation
Binding sitei227 – 2271Pyridoxal phosphateUniRule annotation
Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
Binding sitei283 – 2831Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSGRI455632:GD3A-3436-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:SGR_3413Imported
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)Imported
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000001685: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei228 – 2281N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_3413.

Structurei

3D structure databases

ProteinModelPortaliB1VMD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1364Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiYLATWRT.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

B1VMD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSETTTTARD LRERAAVLDA ADPLAARREL FALDDGVYLD GNSLGALPVH
60 70 80 90 100
VPARVQDVLT RQWGQLRIRS WDESGWWTAP ERIGDRIAPL VGAAAGQIVV
110 120 130 140 150
GDSTSVNVFK AVVAAGRLAG EGRDEILVDA TTFPTDGYIA SAAARLTGHR
160 170 180 190 200
IVPVAPADVP AALGPRTAAV LLNHVDYRSG RLHDLPGLTA AVHAAGAVVV
210 220 230 240 250
WDLCHSAGAL PVGLDEHRVD LAVGCTYKYL NGGPGSPAYL YVAERHQAAF
260 270 280 290 300
DSPLPGWNSH ADPFGMTSGY APADGSVRGR VGTPDIVSML TLEAALDVWD
310 320 330 340 350
GVPVDAVRAK SLALTDFFLE CVEAYVPAGR VTSVTPAAHA ERGSQVALRC
360 370 380 390 400
AEAEPVMRRL IERGVVGDLR RPDVLRFGFT PLYVGFADAE RAARILAEVL
410
AEVSAGDTVG
Length:410
Mass (Da):43,258
Last modified:May 20, 2008 - v1
Checksum:i795BDBD4DE73799C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG20242.1.
RefSeqiYP_001824925.1. NC_010572.1.

Genome annotation databases

EnsemblBacteriaiBAG20242; BAG20242; SGR_3413.
GeneIDi6214162.
KEGGisgr:SGR_3413.
PATRICi23753396. VBIStrGri32265_3487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA. Translation: BAG20242.1 .
RefSeqi YP_001824925.1. NC_010572.1.

3D structure databases

ProteinModelPortali B1VMD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 455632.SGR_3413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG20242 ; BAG20242 ; SGR_3413 .
GeneIDi 6214162.
KEGGi sgr:SGR_3413.
PATRICi 23753396. VBIStrGri32265_3487.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242437.
KOi K01556.
OMAi YLATWRT.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci SGRI455632:GD3A-3436-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350."
    Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., Yamashita A., Hattori M., Horinouchi S.
    J. Bacteriol. 190:4050-4060(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 4626 / NBRC 13350Imported.

Entry informationi

Entry nameiB1VMD2_STRGG
AccessioniPrimary (citable) accession number: B1VMD2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3