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B1VI96 (B1VI96_CORU7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008
Ordered Locus Names:cu1520
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis SAAS SAAS023451 HAMAP MF_00008 RuleBase RU000500
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451 EMBL CAQ05480.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1561 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
B1VI96 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 5448C3FA0EE1201E

FASTA27330,914
        10         20         30         40         50         60 
MSEAQTSPTI ATPYEDLLSK ILAEGAKKDD RTGTGTTSLF GQQIRFNLAE SFPLITTKSV 

        70         80         90        100        110        120 
HVKSVVGELL WFLSGDSNVR WLQDNGIRIW NEWADEDGDL GPVYGVQWRS WPTPDGRHID 

       130        140        150        160        170        180 
QISQALEMLK QNPDSRRNIV SAWNVSELEN MALPPCHLLF QLYVADGKLS CQLYQRSADM 

       190        200        210        220        230        240 
FLGVPFNIAS YSLLTHMFAQ QTGLEVGEFI WTGGDCHIYD NHREQVELQL SREPRPYPQL 

       250        260        270 
ELTKAKDMFS YGFEDVNFVG YDPHPVIKAK VAV

« Hide

References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942444 Genomic DNA. Translation: CAQ05480.1.
RefSeqYP_001800914.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VI96.
SMRB1VI96. Positions 14-273.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VI96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6185148.
GenomeReviewsGene locus cu1520 in contig AM942444_GR.
KEGGcur:cur_1520.
PATRIC21522802. VBICorUre58120_1513.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMARMALAPC.
ProtClustDBPRK01827.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1VI96_CORU7
AccessionPrimary (citable) accession number: B1VI96
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info