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Protein

Dihydrolipoyl dehydrogenase

Gene

cu1841

Organism
Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciCURE504474:GJ8Y-1890-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:cu1841Imported
OrganismiCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109)Imported
Taxonomic identifieri504474 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001727 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi504474.cur_1841.

Structurei

3D structure databases

ProteinModelPortaliB1VI00.
SMRiB1VI00. Positions 4-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 330326FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini351 – 464114Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
KOiK00382.
OMAiVELAWFY.
OrthoDBiEOG6QCD6D.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VI00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHYDVVVI GAGPGGYVAA IRAAQLGLKT AVVEKQYWGG VCLNVGCIPS
60 70 80 90 100
KALIRNAELA HTITKEAKTF GITGDNISMD FGAAHKRSRK VSSSIVKGVH
110 120 130 140 150
YLMKKNKIQE INGRGEFVSD KEISIVDGDD KGKKITFDNA IIATGSVVKS
160 170 180 190 200
LPGVEIGGNI VSYEEQILDE NAPKSMVIIG AGAIGMEFAY VLSNFGVDIT
210 220 230 240 250
VVEFMDRVLP NEDKDVSREI AKQYKRLGVN LKTGHKTTEV RDLGEGKGVE
260 270 280 290 300
VDIESADGKK SETLKADRVM VSIGFAPRTE GLGLDKAGVE LGERGEIVID
310 320 330 340 350
ERMRTSAKNI YAIGDVTAKL QLAHVAEAQG VVAAETIAGA ETQELGDYQM
360 370 380 390 400
MPRATFCNPQ VASFGYTEEA ARKKAEEDGR EIKVATFPYT ANGKAQGLGN
410 420 430 440 450
AVGFVKLIAD AEFGELLGGH MVGPDVSELL PELTLAQRFD LTADEISRNV
460 470
HTHPTLSEAM KEAAHGIGGH MINL
Length:474
Mass (Da):50,718
Last modified:May 20, 2008 - v1
Checksum:i655E1BCA00F10F6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942444 Genomic DNA. Translation: CAQ05800.1.
RefSeqiWP_012361075.1. NC_010545.1.

Genome annotation databases

EnsemblBacteriaiCAQ05800; CAQ05800; cu1841.
KEGGicur:cu1841.
PATRICi21523440. VBICorUre58120_1822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942444 Genomic DNA. Translation: CAQ05800.1.
RefSeqiWP_012361075.1. NC_010545.1.

3D structure databases

ProteinModelPortaliB1VI00.
SMRiB1VI00. Positions 4-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi504474.cur_1841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ05800; CAQ05800; cu1841.
KEGGicur:cu1841.
PATRICi21523440. VBICorUre58120_1822.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
KOiK00382.
OMAiVELAWFY.
OrthoDBiEOG6QCD6D.

Enzyme and pathway databases

BioCyciCURE504474:GJ8Y-1890-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
    Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
    J. Biotechnol. 136:11-21(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43042 / DSM 7109Imported.

Entry informationi

Entry nameiB1VI00_CORU7
AccessioniPrimary (citable) accession number: B1VI00
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 13, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.