Skip Header

Contribute Send feedback
Read comments (?) or add your own

B1VHS5 (B1VHS5_CORU7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:cu1766
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6471Zinc By similarity HAMAP MF_00172
Metal binding6491Zinc By similarity HAMAP MF_00172
Metal binding7321Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
B1VHS5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: DB5D7C7DAF60E669

FASTA76084,054
        10         20         30         40         50         60 
MTFHATTAGV PRIGPDRELK KALEAYWRDS ATGRDLAGTA TRLVNDYTDG LVNEGLDSAP 

        70         80         90        100        110        120 
FQGRSYYDAI LDTSAILGAL PERVADISDH ENDGLPQFID RLFAAARGTA ELPASAMTKW 

       130        140        150        160        170        180 
FDTNYHYIVP ELSADQEFRL EDGAWLDDIR DQVNRHGDKV RPVLVGPFTY LALARSTDGS 

       190        200        210        220        230        240 
NPLEHLESLF ETYGRLLPRI ADRGVTWLQL DEPSLVTDVD PATLSRVKAG YKKLTQLAHD 

       250        260        270        280        290        300 
AGLKLLVQTY YGDADQAIKT LSGLGIDAFG ADLVAGGKEL PNWTGEELLV AGVVDGRNIW 

       310        320        330        340        350        360 
RTDLDAALET LKALAERGPV AVSTSASLLH VPYTLSRETT LSDELRSWLA FGEEKIREVA 

       370        380        390        400        410        420 
LLSRVLRGEG TEADEKALAE AREAVQSRAT SKLTHNDEVR ERTAKITEED RHRGDIEERR 

       430        440        450        460        470        480 
KAQQEELNLP PLPTTTIGSF PQTTQIRQAR AKLRKGEITE EQYTQAMRDE IADVIERQEK 

       490        500        510        520        530        540 
LDLDVLVHGE PERNDMVQYF SEQLEGYHST EHAWVQSYGS RCVRPPILFG DVRRPEPMTV 

       550        560        570        580        590        600 
SWFEEAQKLT DKPVKGMLTG PVTMLAWSFV RDDQPLGETA DQVALALRDE IDDLVSAGAK 

       610        620        630        640        650        660 
VVQVDEPAIR ELLPLREAEQ PAYLKWAVGS FRLATSGVAP KTQIHTHMCY SEFNELIGTV 

       670        680        690        700        710        720 
GDLDADVTSI EAARNGMQVL AALHEAGYDL GVGPGVWDIH SPRVPKQEEV DQLLADALAN 

       730        740        750        760 
VAPELLWVNP DCGLKTRGWE ETTASLEVLV DAAKKARATL

« Hide

References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942444 Genomic DNA. Translation: CAQ05725.1.
RefSeqYP_001801159.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VHS5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VHS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6185058.
GenomeReviewsGene locus cu1766 in contig AM942444_GR.
KEGGcur:cur_1766.
PATRIC21523286. VBICorUre58120_1746.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1VHS5_CORU7
AccessionPrimary (citable) accession number: B1VHS5
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info