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B1VGY4 (B1VGY4_CORU7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:cu1065
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding30 – 356NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding53 – 553NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding95 – 973NADP By similarity PIRSR PIRSR000109-3
Region149 – 1513Substrate binding By similarity PIRSR PIRSR000109-2
Region206 – 2072Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site2031Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2101Proton donor By similarity PIRSR PIRSR000109-1
Binding site1231NADP By similarity PIRSR PIRSR000109-3
Binding site1231Substrate By similarity PIRSR PIRSR000109-2
Binding site2111Substrate By similarity PIRSR PIRSR000109-2
Binding site2811Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site3081Substrate By similarity PIRSR PIRSR000109-2
Binding site4691Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4751Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B1VGY4 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 0646DC956DC38783

FASTA49953,414
        10         20         30         40         50         60 
MSKPSAPNLS SNQAPAGAPD GELAQIGVIG LAVMGSNIAR NFANHGHTVA VFNRTFARTE 

        70         80         90        100        110        120 
GFMENFGEQG SFIPAETLEA FVASLEKPRR ALIMVQAGPA TDAMIEQLAD LMDPGDIIID 

       130        140        150        160        170        180 
GGNALYTDTI RREKEISARG LHFVGTGISG GEEGALNGPA IMPGGTAEAY ESLGPLLESI 

       190        200        210        220        230        240 
SAKVDGEPCC AHIGPDGAGH FVKMVHNGIE YADMQVIGEA YHLLRYGAGL SPKEISEVFR 

       250        260        270        280        290        300 
EWNTGELESY LVEITAEVLA QVDAETGKPL VDIIVDAAGQ KGTGRWTVKS ACDLGIPVTG 

       310        320        330        340        350        360 
IGEAVFARAL SSDGPARQAA QGKLASGELA TPVDPAQRAD FIEDVRRALY ASKMVAYAQG 

       370        380        390        400        410        420 
FDQILAGSEE YGWDVDPRDL ARIWRGGCII RARFLNRIVD AYEADRQLPS LLLDEYFLEQ 

       430        440        450        460        470        480 
MSGLVDSWRR VVGTATAQGH PVPVFASSLS YYDSLRAQRL PAALIQGQRD FFGAHTYGRV 

       490 
DKPGAFHTLW SGDRSEVEA

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References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942444 Genomic DNA. Translation: CAQ05025.1.
RefSeqYP_001800459.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VGY4.
SMRB1VGY4. Positions 24-491.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VGY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6184717.
GenomeReviewsGene locus cu1065 in contig AM942444_GR.
KEGGcur:cur_1065.
PATRIC21521868. VBICorUre58120_1062.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1VGY4_CORU7
AccessionPrimary (citable) accession number: B1VGY4
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info