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B1VGF6 (B1VGF6_CORU7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:cu1304
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length942 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
B1VGF6 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 5852BAA4728E22CA

FASTA942105,180
        10         20         30         40         50         60 
MANKPQSDSE DRRTPSVGED THFGNIRDGV ASYLVDSDPE ETQEWMDSLD GLLDNAGPDR 

        70         80         90        100        110        120 
GRYLMLRLLE RATAKRVPLP PLTSTDYVNT IPTTMEPEFP GDEEMEKRYR RWTRWNAAVM 

       130        140        150        160        170        180 
VHRAQRSGIG VGGHISTYAS AAPLYEVGLN HFFRGKDHPG GGDHIFFQGH ASPGMYARAY 

       190        200        210        220        230        240 
LEGRLSEEQL DAFRQEASKP EVGLPSYPHP HGMPEFWEFP TVSMGLGPLN AIYQARFNRY 

       250        260        270        280        290        300 
LHDRGLKDTS EQHVWAFLGD GEMDEPESRG AIQMAALHNL DNLTFVVNCN LQRLDGPVRG 

       310        320        330        340        350        360 
NTKIIQELES FFRGAGWNVI KVIWGREWDE LLEKDKDGAL VDVMNNTSDG DYQTFKANDG 

       370        380        390        400        410        420 
AYVREHFFNR DPRTKKLVED MSDEEIWALP RGGHDYRKIY AAYARAMETK DQPTVILAHT 

       430        440        450        460        470        480 
IKGYGLGHNF EGRNATHQMK SLSLEDLKQF RTKQDIPISD ETLEKDPELP PYYHPGADAP 

       490        500        510        520        530        540 
EIEYMLNRRK ELGGFLPERR QHFEPLAVPE VETMRSALKG SGKQKVATTM ALVRIVRDFM 

       550        560        570        580        590        600 
RDETMAERLV PIIPDEARTF GLDSWFPTLK IYNTHGQNYT PVDHDLMLSY REAKDGQILH 

       610        620        630        640        650        660 
EGITEAGSVG SFIAAGSSYA THGKAMIPLY IFYSMFGFQR TGDSIWAAAD QMSRGFLIGA 

       670        680        690        700        710        720 
TAGRTTLTGE GLQHMDGHSP VLATTNPAVV TYDPAFAYEI AHILRDGVQR MYGEGSGPDG 

       730        740        750        760        770        780 
DGQGEDVIYY LTVYNEPMHQ PAQPENLDVE GLLKGIYLWS PADKLVGIDE GITGDAGEAE 

       790        800        810        820        830        840 
ELEHTANILA SGVGMGQAIR AKQMLAHYGV NTNIFSVTSW NELARDGQEA GLEELRNPGE 

       850        860        870        880        890        900 
EPRTPYIQQV LEGYDGPFIA VSDFATALHE QVRRWVPGDF INLGADGFGF SDTRAAARRY 

       910        920        930        940 
FNIDAESIVV ATLLSLAREG KIDRKIAIKV AEDLNVGDPT KA

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References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942444 Genomic DNA. Translation: CAQ05263.1.
RefSeqYP_001800698.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VGF6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VGF6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6186073.
GenomeReviewsGene locus cu1304 in contig AM942444_GR.
KEGGcur:cur_1304.
PATRIC21522360. VBICorUre58120_1302.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1VGF6_CORU7
AccessionPrimary (citable) accession number: B1VGF6
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info