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B1VGA2 (B1VGA2_CORU7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:cu0831
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding13 – 4230NADP By similarity HAMAP MF_00183

Sites

Metal binding1571Divalent metal cation By similarity HAMAP MF_00183
Metal binding1591Divalent metal cation By similarity HAMAP MF_00183
Metal binding2281Divalent metal cation By similarity HAMAP MF_00183
Binding site1341Substrate By similarity HAMAP MF_00183
Binding site1591Substrate By similarity HAMAP MF_00183
Binding site1831Substrate By similarity HAMAP MF_00183
Binding site2061Substrate By similarity HAMAP MF_00183
Binding site2281Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
B1VGA2 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 01BB08A832CD8111

FASTA39742,288
        10         20         30         40         50         60 
MAMTFDKTRV VILGSTGSIG VQALEVVFDN PEQFEVIGIS AHGSKPELLL EQAQKIGLPA 

        70         80         90        100        110        120 
ERVAVASDRT ADFVEAQLGG HCIRGQDSAR DLVEELGDQL ESTDVILNAL VGSQGLEATL 

       130        140        150        160        170        180 
SSLGTQARLA LANKESLVAG GQLVLDAADE GQLVPVDSEH SAMAQCLRSG RRDEVATLVL 

       190        200        210        220        230        240 
TASGGPFRGW TREQLEPVTP LQAASHPTWS MGQMNTLNSA TMVNKGLELI EACLLFDMPS 

       250        260        270        280        290        300 
NRVEVTVHPQ SIVHSMVTFR DGSTIAQASP PSMKLPISLA LGWPNRVAGV GQPLDFTQAA 

       310        320        330        340        350        360 
TWEFEPLDDE VFPAVELARE AAKAGGVMPA IYNAANEEAA IEFLNANMAF PRIVDTVEAV 

       370        380        390 
MSASGAASTP TCLEDVLEAE REARALAHER MRPWLLG

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References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942444 Genomic DNA. Translation: CAQ04791.1.
RefSeqYP_001800225.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VGA2.
SMRB1VGA2. Positions 7-388.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VGA2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6185027.
GenomeReviewsGene locus cu0831 in contig AM942444_GR.
KEGGcur:cur_0831.
PATRIC21521390. VBICorUre58120_0831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1VGA2_CORU7
AccessionPrimary (citable) accession number: B1VGA2
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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